Storage liquid of human umbilical cord mesenchymal stem cells

A technology for stem cells and human umbilical cord, applied in the field of stem cell biology, can solve the problems of decreased activity of human umbilical cord mesenchymal stem cells, inability to large-scale application, and limitation of large-scale production and long-distance supply of human umbilical cord mesenchymal stem cells, To achieve the effect of long-distance transportation and widespread clinical promotion, convenient transportation and temporary storage, and the effect of promoting survival and migration
CN107410288AActive Publication Date: 2017-12-01刘劼 +9
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
刘劼
Publication Date
2017-12-01
Patent Text Reader

Abstract

The invention provides storage liquid of human umbilical cord mesenchymal stem cells, and belongs to the field of stem cell biology. The storage liquid belongs to a composition of stem cell storage liquid suitable for clinic application. Various active ingredients are used for optimizing the storage conditions, and comprise a mixed water solution containing sodium chloride, albumin, adenosine, angiotensin-II, lithium chloride, flavonoids compounds, heparin, andhuman umbilical cord mesenchymal stem cell sourced exosome, oligopeptide and polypeptide compounds. In the storage liquid, the cell activity of the human umbilical cord mesenchymal stem cells under the condition of 4 DEG C in 3 days is maintained at 90 percent or higher; in addition, the cell phenotype is stable; the cell activity can still be maintained at 90 percent or higher in 7 days under the condition of -20 DEG C; the cell phenotype is also stable. The storage liquid maintains the stable quality of the stem cells; the long-distance conveyance of the stem cells can be realized; the foundation is laid for the wide application of the clinic stem cells.
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Description

technical field

[0001] The invention relates to the field of stem cell biology, in particular to a human umbilical cord mesenchymal stem cell storage solution. Background technique

[0002] As a widely used stem cell, human umbilical cord mesenchymal stem cells are easy to obtain, easy to separate, have low immunogenicity, and have the advantages of multi-directional differentiation potential. They can be applied to clinical disease treatment and anti-aging of the body . With the standardized application of stem cell technology in the field of biological therapy, especially its advantages in the treatment of chronic diseases such as hypertension and coronary atherosclerosis, it can improve the body's function and quality of life as a whole, which has been widely concerned and is becoming more and more popular. More and more clinical applications.

[0003] The storage environment of human umbilical cord mesenchymal stem cells is closely related to the long-term activity of ...

Claims

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