Composition comprising benzyl alcohol derivatives and other antimicrobial active compounds

A technology of composition and compound, applied in the medicine for treating Aspergillus niger, antimicrobial active compound, antimicrobial composition, synergistically enhancing the antimicrobial activity of some antimicrobial active substances, dealing with Aspergillus niger, can solve the effect of Aspergillus niger not enough

Active Publication Date: 2017-12-01
SYMRISE GMBH & CO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although substances such as 1,2-alkanediols with 3-14 carbon atoms are known to have considerable activity against certain bacteria and microorganisms, the action against Aspergillus niger was considered insufficient in many cases

Method used

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  • Composition comprising benzyl alcohol derivatives and other antimicrobial active compounds
  • Composition comprising benzyl alcohol derivatives and other antimicrobial active compounds
  • Composition comprising benzyl alcohol derivatives and other antimicrobial active compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1a

[0434] Example 1a: a mixture comprising 1,2-hexanediol and 1,2-octanediol (product A, not according to the invention), comprising 4-methylbenzyl alcohol (product B, not according to the invention) and comprising 1 , Comparison of Adequate Preservation of Cosmetic Preparations of a Mixture of 2-Hexanediol, 1,2-Octanediol and 4-Methylbenzyl Alcohol (Product C, According to the Invention).

[0435] Adequate preservative tests are carried out in accordance with the European Pharmacopoeia.

[0436]The test thus consists of contaminating the preparation (if possible, the preparation in its final state) with a defined inoculum of suitable microorganisms, storing the inoculated preparation at a certain temperature, removing samples from the container at certain time intervals and determining the samples thus removed. The number of microorganisms in . Preservation is adequate if, under the test conditions, there is a marked reduction or, where appropriate, no increase in the number of...

Embodiment 1b

[0461] Example 1b: a mixture comprising 1,2-hexanediol and 1,2-octanediol (product A, not according to the invention), comprising 4-methylbenzyl alcohol (product B, not according to the invention) and comprising 1 , Comparison of Adequacy of Preservation of Cosmetic Preparations of a Mixture of 2-Hexanediol, 1,2-Octanediol and 4-Methylbenzyl Alcohol (Product C, According to the Invention)

[0462] Sufficient preservation tests were carried out according to the European Pharmacopoeia as described in Example 1a.

[0463] Test bacteria:

[0464] Use the following microbial strains for adequate preservative testing:

[0465] A: Escherichia coli ATCC 8739

[0466] B: Pseudomonas aeruginosa ATCC 9027

[0467] C: Staphylococcus aureus ATCC 6538

[0468] D: Candida albicans ATCC 10231

[0469] E: Aspergillus niger ATCC 16404

[0470] In each test series, the initial bacterial counts (cfu / ml; "0 value") ranged from 230,000 to 400,000.

[0471] preparation:

[0472] For the adeq...

Embodiment 2

[0487] Example 2: Comprising 1,2-octanediol (product A, not according to the invention), comprising 4-methylbenzyl alcohol (product B, not according to the invention) and comprising 1,2-octanediol and 4-methanol Adequate preservative comparison of cosmetic preparations of mixtures of benzyl alcohols (product C according to the invention)

[0488] Sufficient preservation tests were carried out according to the European Pharmacopoeia as described in Example 1a.

[0489] Test bacteria:

[0490] Use the following microbial strains for adequate preservative testing:

[0491] A: Escherichia coli ATCC 8739

[0492] B: Pseudomonas aeruginosa ATCC 9027

[0493] C: Staphylococcus aureus ATCC 6538

[0494] D: Candida albicans ATCC 10231

[0495] E: Aspergillus niger ATCC 16404

[0496] In each test series, the initial bacterial counts (CFU / g; "0 value") ranged from 230,000 to 400,000.

[0497] preparation:

[0498] For the adequate preservation test, the defined amount of active co...

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Abstract

The invention relates to a composition comprising benzyl alcohol derivatives and other antimicrobial active compounds. The composition includes: (a) one, two or more compounds, which are selected from benzyl alcohol derivatives represented in the formula (I), wherein the substituent groups R1, R2 and R3 are defined as the claim 1; (b) one, two or more compounds selected as the follows: (i) 1,2-alkyldiol having 3-14 carbon atoms and having or not having a branched chain; (ii) benzoic acid, as well as an ester and a salt thereof; (iii) 4-hydroxybenzoic acid, as well as an ester and a salt thereof; (iv) 2,4-hexadienoic acid and a salt thereof; (v) 2-phenoxyethanol; (vi) 3-iodo-2-propynyl butylcarbamate; (vii) 3-(4-chlorophenoxy)-1,2-propane-1,2-diol; (viii) urea and a derivative thereof; (ix) 1,3-bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione; (x) 3-(2-ethylhexyloxy)-1,2-propylene glycol; and (xi) isothiazolinone and a mixture thereof.

Description

[0001] This application is a divisional application of the Chinese patent application with application number 200880130767.9. The original application is the PCT international application PCT / EP2008 / 059037 filed on July 10, 2008, which entered the Chinese national phase on February 16, 2011. technical field [0002] The present invention relates to the field of antimicrobial actives and, in particular, to certain (synergistic) antimicrobial compositions (mixtures) comprising or consisting of: (a) at least one benzyl alcohol-derived and (b) at least one antimicrobially active compound selected from subgroups (i)-(xi) as described in more detail below. The most preferred benzyl alcohol derivative is 4-methylbenzyl alcohol. Most preferred as constituents of group (b) are 1,2-alkanediols having 3 to 14 carbon atoms. Other preferred compositions are described in more detail below and / or defined in the accompanying claims. [0003] The present invention also relates to the use of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/04A01N31/02A01P3/00A01P1/00A61K8/34A61Q17/00
CPCA01N31/02A01N31/04A61K8/34A61K8/345A61K2800/524A61Q5/02A61Q11/00A61Q15/00A61Q17/005A61Q17/04A61Q19/00A61Q19/004A61Q19/02A61Q19/04A01N2300/00A61K8/046A61K8/062A61K8/064A61K2800/874A61P31/00A61P31/10A01N35/02A01N37/06A01N37/10A01N37/40A01N39/00A01N43/50A01N43/80A01N47/12A01N47/28A01N47/36
Inventor 格哈德·施毛斯安特耶·法伊弗
Owner SYMRISE GMBH & CO KG
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