Multidrug infusion for pain control

A technology of preparations and antagonists, which is applied in the field of multi-drug injection for pain control, and can solve problems such as poor control of pain and side effects

Pending Publication Date: 2017-12-01
DGB治疗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pain is often poorly controlled and has unacceptable side effects in some patients despite multimodal systemic approaches to alleviate systemic side effects with minimal doses of drugs

Method used

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  • Multidrug infusion for pain control
  • Multidrug infusion for pain control
  • Multidrug infusion for pain control

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0156] Pain Management via Intrathecal Infusion

[0157] To explore the efficacy of alternative methods of pain management based on time-limited intrathecal (IT) infusions of anesthetic agent mixtures, patients with refractory and poorly controlled pain due to decubitus ulcers, pelvic metastatic masses, and thoracic spine and rib fractures were treated, respectively. The three patients in the study were 69, 64 and 94 years old. Due to side effects, daily doses of opioids should not be increased. Intrathecal catheter 20G is placed percutaneously in the lumbar region while being advanced thoracically into the channel and secured subcutaneously. It was connected to an external infusion pump with a mixture of bupivacaine 1 mg / ml, oxymorphone 0.02 ng / ml, ketamine 100 μg / ml, morphine 0.01 mg / ml and clonidine 0.75 μg / ml. The initial rate was 1 ml / h. Pain is mainly controlled at a rate of less than 1ml / h. Opioid consumption has been greatly reduced. The catheter was maintained fo...

example 2

[0190] Pain management via infusion in the right brachial plexus

[0191] A 66-year-old elderly patient with subarachnoid hemorrhage (SAHI grade) with ruptured aneurysm of the carotid artery left middle cerebral artery vasospasm. The patient presents with severe right hemiplegic spasticity following a stroke. The spasticity caused significant pain due to contractures and poor positioning of the right arm. It has dysesthesia, allodynia, and hyperalgesia to touching surfaces. The patient also had problems with aphasia, but communicated well.

[0192] Conventional treatments for pain and drug trials (Botox in 2011 and Baclofen 10 mg base in 2013) yielded minimal results and provided no relief.

[0193] The patient had been seeing the pain clinic since February 2014, and intravenous infusions of ketamine were well tolerated but did not provide any relief in pain levels. Blockage of the right arm at the level of the brachial plexus with analgesic solution has been performed wit...

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Abstract

The present invention relates to a formulation comprising an opioid, a Na channel blocker, an alpha2-receptor agonist, an opioid mu or delta receptor competitive antagonist and an intravenous anesthetic and / or a neurologic acting agent for use in pain control and / or cognitive function improvement.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of U.S. Patent Application No. 14 / 845,546 filed September 4, 2015 under 37CFR1.53(b), which enjoys U.S. provisional application filed September 4, 2014 under 35USC119(e) Priority and benefit to patent application 62 / 045,750, the specification of which is hereby incorporated by reference in its entirety. Background technique [0003] Achieving effective, durable, and safe analgesia may be a clinical challenge, especially in elderly patients and advanced malignancies. Despite multimodal systemic approaches to alleviate systemic side effects with minimal doses of drugs, in some patients pain is often poorly controlled and has unacceptable side effects. Contents of the invention [0004] According to one embodiment of the present invention, there is provided a preparation for pain control and / or cognitive function improvement, comprising: [0005] opioids; [0006] Na channel b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P25/04A61P25/28
CPCA61K9/0019A61K45/06A61K9/0085A61K31/135A61K31/4168A61K31/445A61K31/485A61P25/04A61P25/28A61P29/00A61P43/00A61K2300/00A61K31/4458
Inventor 吉尔伯特·布莱斯
Owner DGB治疗有限公司
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