Medicine liquid for treating onychomycosis, and preparation method and application thereof

Abstract

The invention relates to medicine liquid for treating onychomycosis, and a preparation method and application thereof. The medicine liquid consists of the following components in percentage by weight: 0.01 to 2.5 percent of fungicide, 0.01 to 1.0 percent of oleum fructus bruceae, 0.05 to 1.0 percent of golden cypress extract, 5 to 30 percent of glacial acetic acid, 0.005 to 0.5 percent of menthol, 0.01 to 1.0 percent of an emulsifier and the balance of water, wherein the fungicide is selected from one or more of benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate and polyhexamethylene guanidine hydrochloride. The medicine liquid can remarkably kill escherichia coli, staphylococcus aureus and candida albicans, can effectively treat the onychomycosis, and has the advantages of safety, no toxic or side effect, rapid response, convenience and low cost.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicinal solution for treating onychomycosis, a preparation method and application thereof. Background technique [0002] Onychomycosis (toe) nail is a common name for fingernails or toenails caused by fungal infection, and it is medically called onychomycosis. This is a nail disease mainly caused by dermatophytes (mainly Trichophyton rubrum, accounting for about 85%), yeast and other fungal infections. Patients who suffer from tinea pedis for a long time, up to 50% can then infect and become gray finger (toe) nail. [0003] In the past, the treatment of onychomycosis (toe) nails was mainly based on external medication, oral systemic medication, softening and removing nails, and surgical nail removal. The typical treatment method of external medicine is: 1) first remove the diseased nail as much as possible with a knife or a nail file, then rub it with 30% glacial acetic ac...

AI Technical Summary

Problems solved by technology

The treatment mode of external medicine generally exists following obvious defect: the one, the treatment process is loaded down with trivial details, and the patient can not insist on completing the treatment process, just in the patient's treatment process, there is no compliance, thereby can't cure gray finger (toe) nail; It is the low efficiency of drug penetration and absorption, which is also a key factor affecting the treatment

The damage to the liver caused by oral systemic medication is not easy to avoid. Therefore, in fact, very few patients with onychomycosis are willing to use the above-mentioned related regimen for treatment. Therefore, this regimen is only of clinical academic significance. without clinical significance

There is also a combined treatment plan that uses external methods of treatment and oral antifungal drug systemic (systemic) treatment at the same time, in order to improve the therapeutic effect, but this program does not fundamentally bring convenience (treatment) to patients with gray finger (toe) nails. The method is simple), efficient (due to the convenience of use to improve compliance, thereby increasing the cure rate) and safety (mainly because liver damage cannot be avoided), therefore, the cure rate of gray finger (toe) nail has not been improved clinically

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