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Liposome preparation for delivering wnt signaling pathway inhibitor and preparation method thereof

A liposome preparation and signaling pathway technology, which is applied in the field of liposome preparations for delivering Wnt signaling pathway inhibitors and their preparation, and can solve problems such as toxic effects hindering clinical trial research and the like

Active Publication Date: 2018-07-13
CUREGENIX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Toxic effects of Wnt signaling pathway inhibitors as a new class of drugs hinder further clinical trial studies

Method used

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  • Liposome preparation for delivering wnt signaling pathway inhibitor and preparation method thereof
  • Liposome preparation for delivering wnt signaling pathway inhibitor and preparation method thereof
  • Liposome preparation for delivering wnt signaling pathway inhibitor and preparation method thereof

Examples

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Embodiment 1

[0049] Example 1. Liposome formulations for delivery of Wnt signaling pathway inhibitors and preparation methods thereof

[0050] This example illustrates the liposome preparation and preparation method for delivering Wnt signaling pathway inhibitors of the present invention. In this example, compound 28 is used as an example of Wnt signaling pathway inhibitors, and liposomes are prepared by the following method agent.

[0051] method:

[0052] (i) preparing an alcoholic solution of lipid molecules: dissolving soybean lecithin and cholesterol in an ethanol solution with a molar ratio of 20:1 to form an alcoholic solution of lipid molecules;

[0053] (ii) preparation concentration is the ethanol solution of the Wnt signaling pathway inhibitor of 1mg / ml;

[0054] (iii) The alcohol solution of the lipid molecules prepared above and the ethanol solution of the Wnt signaling pathway inhibitor are fully mixed (the molar ratio of the Wnt signaling pathway inhibitor to the total amo...

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Abstract

Provided herein is a liposome formulation for delivering a Wnt signaling pathway inhibitor, which comprises a lipid molecule and a Wnt signaling pathway inhibitor, wherein the concentration of the Wnt signaling pathway inhibitor loaded in the liposome formulation is 0.07mg / ml to 0.5mg / ml.

Description

technical field [0001] The invention relates to a liposome preparation for delivering Wnt signal pathway inhibitors and a preparation method thereof. Background technique [0002] The Wnt signaling pathway is involved in a variety of complex biochemical reactions in cells, not only plays a vital role in the regulation of embryonic development, but also has a close relationship with the dysfunction of Wnt pathway and the occurrence of tumors. At present, the relationship between the Wnt signaling pathway and human tumors has attracted much attention, and it is a research hotspot at the forefront of the world. Existing experiments have shown that Wnt signaling pathway inhibitors can be widely used in the field of tumors. As a new type of drug, Wnt signaling pathway inhibitors have been hindered by their toxic effects in further clinical trials. [0003] Liposome is a tiny vesicle of phospholipid bilayer similar to the cell membrane structure. As a good drug carrier, it has g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K31/444A61K31/496A61K31/497A61K31/5377A61K31/4985A61K31/4725A61K31/501A61K31/4375A61K31/541A61K31/506A61P35/00
CPCA61K9/127A61K31/4375A61K31/444A61K31/4725A61K31/496A61K31/497A61K31/4985A61K31/501A61K31/506A61K31/5377A61K31/541A61K47/28A61P35/00A61K9/0019A61K47/46
Inventor 徐宇虹屠梅青陈晓静
Owner CUREGENIX