A screening method for progesterone chemical risk substances in toiletries

A technology for cleaning products and progesterone, which is applied in the field of screening of progesterone chemical risk substances, can solve the problems of unreported detection methods, lagging supervision of chemical risk substances, and insufficient prevention capabilities, so as to speed up sustainable and healthy development, Effects of standardizing market economic rules and operating order, promoting healthy and standardized development

Active Publication Date: 2019-11-12
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. The supervision of chemical risk substances in toiletries is relatively lagging behind, and the prevention ability is insufficient
However, there is no report on the detection method of toilet products using high-resolution mass spectrometry.

Method used

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  • A screening method for progesterone chemical risk substances in toiletries
  • A screening method for progesterone chemical risk substances in toiletries
  • A screening method for progesterone chemical risk substances in toiletries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A method for detecting progesterone chemical risk substances in toiletries, comprising the steps of:

[0051] After the pretreatment steps of extraction, centrifugation, purification, filtration and other pretreatment steps, the sample solution obtained by ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection; ultra-high pressure liquid chromatography-quadrupole In rod-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection, the chromatographic separation conditions are as follows:

[0052] Chromatographic column: HSS cyano column, length 50mm, inner diameter 2.1mm, particle size 1.8μm; column temperature: 38°C; flow rate: 0.4mLmin -1 ;Injection volume: 10μL, see Table 1 and Table 2 for mobile phase and gradient elution program:

[0053] Table 1 Chromatographic mobile phase and gradient elution program in positive ion mass spectrometry mode

[0054]

...

Embodiment 2

[0066] 1. Instruments and reagents

[0067] Dionex UltiMate 3000 fast high-performance liquid chromatography system (Thermo Fisher, USA); QExactive Focus quadrupole-electrostatic field orbitrap high-resolution mass spectrometer (Thermo Fisher, USA); Milli-Q ultrapure water instrument (Millipore, USA); Vortex-Genie 2 vortex oscillator (Scientific Industries, USA).

[0068] Methanol, acetonitrile (chromatographically pure, American Thermo Fisher Company); ammonium hydroxide, formic acid (chromatographically pure, American DimaTechnology Company); laboratory water is deionized water. Carbon eighteen, N-propyl ethylenediamine and graphitized carbon black (Germany Macherey-Nagel company); Multi-walled carbon nanotubes (Germany Miltenyi Biotec GmbH company); Anhydrous magnesium sulfate, sodium chloride (Guangzhou Xilong Chemical Industry limited liability company); 0.22 μm microporous membrane (Pall Corporation, USA).

[0069] Prepare 500-1000μg mL respectively -1 The standard st...

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Abstract

The invention discloses a method for screening progesterone chemical risk substances in toiletries, comprising the following steps: (1) establishing an accurate mass database and a mass spectrum library of a compound to be tested; (2) pretreatment and detection of actual samples: After pretreatment steps such as extraction, centrifugation, purification, and filtration, the sample solution of the personal care products is subjected to ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection; (3) Step (2) The obtained test results are compared and analyzed with the accurate mass database and the mass spectrum library established in step (1), and the screening of progesterone chemical risk substances is carried out. The screening method for progesterone chemical risk substances in toiletries established by the invention has high accuracy, strong specificity and high sensitivity, and is applicable to daily detection and quality control of toiletries.

Description

technical field [0001] The invention relates to a screening method for chemical substances, in particular to a screening method for progesterone chemical risk substances in cleaning products based on ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry check method. Background technique [0002] 1. Chemical risk substances in toiletries have potential harmful effects on consumers' personal health. [0003] From the very beginning of its birth, toiletries have provided protection for people's pursuit of a clean, healthy and fashionable life. With the continuous development and progress of society, people's pursuit of a clean, healthy and fashionable lifestyle has also been continuously upgraded, thus driving the development of toiletries. The industry has stepped into the fast lane of development and upgrading. At present, there are a wide variety of products in the cleaning and care products market, and functio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06Y04S30/12Y02T90/167
Inventor 马强孟宪双白桦胡明珠吕悦广郭项雨闫萌萌陈萌
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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