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Screening method for chemical risky substances of progestational hormone in wash supplies

A technology for toiletries and progesterone, which is applied in the field of screening of progesterone chemical risk substances, can solve the problems of insufficient preventive ability, lag in the supervision of chemical risk substances, and unreported detection methods, and achieves the promotion of health and standardized development, The effect of accelerating sustainable and healthy development and standardizing market economic rules and business order

Active Publication Date: 2017-12-29
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. The supervision of chemical risk substances in toiletries is relatively lagging behind, and the prevention ability is insufficient
However, there is no report on the detection method of toilet products using high-resolution mass spectrometry.

Method used

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  • Screening method for chemical risky substances of progestational hormone in wash supplies
  • Screening method for chemical risky substances of progestational hormone in wash supplies
  • Screening method for chemical risky substances of progestational hormone in wash supplies

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A method for detecting progesterone chemical risk substances in toiletries, comprising the steps of:

[0051] After the pretreatment steps of extraction, centrifugation, purification, filtration and other pretreatment steps, the sample solution obtained by ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection; ultra-high pressure liquid chromatography-quadrupole In rod-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection, the chromatographic separation conditions are as follows:

[0052] Chromatographic column: HSS cyano column, length 50mm, inner diameter 2.1mm, particle size 1.8μm; column temperature: 38°C; flow rate: 0.4mLmin -1 ;Injection volume: 10μL, see Table 1 and Table 2 for mobile phase and gradient elution program:

[0053] Table 1 Chromatographic mobile phase and gradient elution program in positive ion mass spectrometry mode

[0054]

...

Embodiment 2

[0066] 1. Instruments and reagents

[0067] Dionex UltiMate 3000 fast high-performance liquid chromatography system (Thermo Fisher, USA); QExactive Focus quadrupole-electrostatic field orbitrap high-resolution mass spectrometer (Thermo Fisher, USA); Milli-Q ultrapure water instrument (Millipore, USA); Vortex-Genie 2 vortex oscillator (Scientific Industries, USA).

[0068] Methanol, acetonitrile (chromatographically pure, American Thermo Fisher Company); ammonium hydroxide, formic acid (chromatographically pure, American DimaTechnology Company); laboratory water is deionized water. Carbon eighteen, N-propyl ethylenediamine and graphitized carbon black (Germany Macherey-Nagel company); Multi-wall carbon nanotubes (Germany Miltenyi Biotec GmbH company); Anhydrous magnesium sulfate, sodium chloride (Guangzhou Xilong Chemical Industry limited liability company); 0.22 μm microporous membrane (Pall Corporation, USA).

[0069] Prepare 500-1000μg mL respectively -1 The standard stoc...

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Abstract

The invention discloses a screening method for chemical risky substances of progestational hormone in wash supplies. The method comprises the following steps: (1) establishing a precise quality database and a mass spectrum library of to-be-tested compounds; (2) pre-treatment and detection of an actual sample: performing pre-treatment steps of extraction, centrifugalization, purification, filtration and the like on a sample of the wash supplies, and performing ultrahigh pressure liquid chromatogram-quadrupole rod-electrostatic field orbitrap high resolution mass spectrum analysis and detection; and (3) comparing and analyzing the test result obtained in the step (2) with the precise quality database and the mass spectrum library established in the step (1) to screen the chemical risky substances of progestational hormone in wash supplies. The screening method for chemical risky substances of progestational hormone in wash supplies disclosed by the invention is high in accuracy, high in specificity and high in sensitivity, and is suitable for daily detection and quality control of the wash supplies.

Description

technical field [0001] The invention relates to a screening method for chemical substances, in particular to a screening method for progesterone chemical risk substances in cleaning products based on ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry check method. Background technique [0002] 1. Chemical risk substances in toiletries have potential harmful effects on consumers' personal health. [0003] From the very beginning of its birth, toiletries have provided protection for people's pursuit of a clean, healthy and fashionable life. With the continuous development and progress of society, people's pursuit of a clean, healthy and fashionable lifestyle has also been continuously upgraded, thus driving the development of toiletries. The industry has stepped into the fast lane of development and upgrading. At present, there are a wide variety of products in the cleaning and care products market, and functio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06Y04S30/12Y02T90/167
Inventor 马强孟宪双白桦胡明珠吕悦广郭项雨闫萌萌陈萌
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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