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Dynamic sweat sensor management

A sensor and sensor device technology, applied in sensors, blood characterization devices, medical science, etc., can solve problems such as lack of sampling devices, difficulty in producing sweat, and errors in results

Inactive Publication Date: 2018-01-09
ECCRINE SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A recent substantial2014 review by Castro entitled "Sweat: A sample with limited present applications and promising future in metabolomics" (Sweat: A sample with limited present applications and promising future in metabolomics) ), which states: "The main limitations of sweat as a clinical sample are: difficulty in producing sweat in sufficient quantities for analysis, sample evaporation, lack of suitable sampling devices, need for trained operators, and errors in the results due to the presence of pilocarpine
When performing quantitative measurements, the main drawback is the standardization of the sampling volume

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0070] Example 1: A patient is undergoing a clinical trial of a new oncology drug. Based on the test profile developed for the trial, the device has been configured to monitor on a near-continuous basis a panel of three analytes whose relative concentrations and concentration trends in sweat provide a reasonable determination of whether a patient is taking a drug. The presence of a fourth analyte in sweat would confirm that the patient has taken the drug, however, the specialized sensor required to detect this analyte is a single-use sensor. Therefore, the device also includes a limited number of disposable sensors. Each disposable sensor is isolated from sweat by a selectively permeable membrane. When the multiple-use sensor indicates that the patient has taken their medication, the device waits a precalculated interval before activating electrodes near the unused disposable sensor, causing the membrane to open and drain sweat to the sensor. The device then activates the di...

example 2

[0071]Example 2: Cyclists compete in multiple periods of a multi-stage race. The estimated battery life of the sweat sensor unit is expected to last a full game day. When a sweat sensor device is first applied, the device undergoes a calibration procedure that is used to determine that the device is in good contact with the skin for proper operation, and to calculate the optimal and minimum activation currents and Voltage. During the competition, the unit takes routine power consumption measurements and determines that the power consumption is greater than expected, and the unit's battery power is not expected to last the full period. The unit also took age-guaranteed readings and found that the minimum time interval for confident sweat readings was 10 minutes. Therefore, the device ensures that the K+ sampling interval is greater than the minimum of 10 minutes, stops supplying the activation current to a part of the K+ sensor group, and reduces the activation current to the...

Embodiment 4

[0073] Example 4: Children with type I diabetes wear a sweat detection device at night according to the doctor's advice. The sweat sensing system consists of a kit of devices configured to monitor hypoglycemic conditions through the amount and ratio of glucose and at least one other relevant analyte (e.g., cortisol) detected in sweat . The kit also contains a bedside transceiver that communicates wirelessly via the Internet with the parent's smartphone. A device is placed on the child's skin while they sleep. When in use, the unit performs a start-up procedure and initial calibration, and establishes communication with the bedside transceiver, which sends a status message to the parent's smartphone that the system is fully operational. When an initial low blood sugar reading is taken and detected to be normal, the device sets the initial test interval to 15 minutes. After 3 hours, the device took a routine hypoglycemia reading, which indicated a downward trend in glucose an...

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Abstract

The disclosure provides: a two-way communication means between a sweat sensing device and a user; at least one means of activating, deactivating, controlling the sampling rate, and controlling the electrical power applied to a particular sweat sensor or group of sensors; a means of isolating a sweat sensor from sweat until needed; a means of selectively stimulating sweat for a particular sweat sensor or group of sensors to manage sweat flow or generation rate; a means of monitoring the power consumption of a sensor device, individual sensors or groups of sensors; a means of monitoring an individual sweat sensor or group of sensors for optimal performance; a means of monitoring whether a sweat sensing patch is in adequate proximity to a wearer's skin to allow device operation; and the ability to use aggregated sweat sensor data correlated with external information to enhance the device's management capabilities.

Description

[0001] Statement of Federally Sponsored Research or Development [0002] This invention was developed with no federal funds. [0003] Cross References to Related Applications [0004] This application is related to U.S. Provisional Application 62 / 120,342 filed on February 24, 2015, the specification of this application is based on application PCT / US14 / 061098 filed on October 17, 2014, and application PCT on October 15, 2015 / US15 / 55756; the disclosures of these patent applications are hereby incorporated by reference in their entirety. Background technique [0005] Sweat sensing technology has great potential in applications such as athletics, neonatology, workforce safety, pharmacological monitoring, and personal digital health. Sweat contains many of the same biomarkers, chemicals, or solutes that are carried in blood, which can provide significant information prior to other signs, allowing for insight into disease, health conditions, toxin exposure, performance, and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B5/053A61B5/145
CPCA61B5/6843A61B5/0531A61B5/14521A61B5/4266A61B2560/0204A61B2560/0209A61B5/14517A61B5/1477
Inventor 詹森·海根菲德罗伯特·比奇
Owner ECCRINE SYST
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