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Traditional Chinese medicine immunopotentiator for vaccine as well as preparation method and application thereof

An immune enhancer, vaccine technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, antiviral agents, etc., can solve the problems of immune failure, poor immune effect, etc. The effect of low molecular weight

Inactive Publication Date: 2018-02-06
商丘美兰生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has also been found in clinical use that when the preparation, product inspection, transportation and use of the swine fever vaccine meet the requirements, there are still cases of poor immune effect or even immune failure after vaccination.

Method used

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  • Traditional Chinese medicine immunopotentiator for vaccine as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A traditional Chinese medicine immunopotentiator for vaccines, the Chinese medicine immunopotentiator for vaccines is a mixed solution made of Achyranthes bidentata polysaccharide, MEM dry powder, thymopentin, HEPES and water, each component in the Chinese medicine immunopotentiator for every 1000ml vaccine The content is: Achyranthes bidentata polysaccharide 25g, MEM dry powder 13.4g, thymopentin 5g, HEPES 2.38g, and the balance is water; wherein, the water is water for injection.

[0028] The preparation method of the traditional Chinese medicine immunopotentiator for above-mentioned vaccine comprises the following steps:

[0029] (1) Take each raw material component by weighing the raw material composition of the above-mentioned Chinese medicine immunostimulant for vaccine, and set aside;

[0030] (2) Get the water of total consumption 85%, add Achyranthes bidentata polysaccharide, MEM dry powder, Thymopentin and HEPES wherein, stir and dissolve evenly, obtain mixed ...

Embodiment 2

[0031] Embodiment 2: the application of Chinese medicine immunopotentiator for vaccine of the present invention

[0032] 1. the vaccine of the present invention uses Chinese medicine immunopotentiator as the application of vaccine diluent

[0033] Using the traditional Chinese medicine immunopotentiator for vaccines prepared in Example 1 of the present invention as the diluent of the live swine fever vaccine, the application experiment was carried out. The specific operation is as follows: each head of swine fever live vaccine is diluted with 1 ml of the vaccine prepared in Example 1 of the present invention with a traditional Chinese medicine immunopotentiator, and after dilution, intramuscular injection is carried out into the neck of the experimental pigs.

[0034] (1) Security inspection:

[0035]Choose about 30 nursery pigs of 15-20kg, and randomly divide them into three groups of A, B, and C, with 10 heads in each group; wherein, the Chinese medicine immunopotentiator f...

Embodiment 3

[0044] A traditional Chinese medicine immunopotentiator for vaccines, the Chinese medicine immunopotentiator for vaccines is a mixed solution made of Achyranthes bidentata polysaccharide, MEM dry powder, thymopentin, HEPES and water, each component in the Chinese medicine immunopotentiator for every 1000ml vaccine The content is: Achyranthes bidentata polysaccharide 15g, MEM dry powder 10g, thymopentin 10g, HEPES 2g, and the balance is water for injection.

[0045] The preparation method of the traditional Chinese medicine immune enhancer for the vaccine is the same as in Example 1.

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Abstract

The invention discloses a traditional Chinese medicine immunopotentiator for a vaccine. The traditional Chinese medicine immunopotentiator for the vaccine is a mixed solution prepared from achyranthesbidentata polysaccharides, MEM dry powder, thymopeptide-5, HEPES and water. Per 1000 ml of traditional Chinese medicine immunopotentiator for the vaccine is prepared from 15 to 30g of achyranthes bidentata polysaccharides, 8 to 18g of MEM dry powder, 2 to 10g of thymopentin, 2 to 3g of HEPES and the balance of water. The invention also discloses a preparation method and application of the traditional Chinese medicine immunopotentiator for the vaccine. The traditional Chinese medicine immunopotentiator for the vaccine provided by the invention can regulate or enhance the body immunologic function, improve the body disease resistance capability and enhance the immune effect of the classical swine fever live vaccine; the preparation process is simple; the popularization is easy.

Description

technical field [0001] The invention belongs to the field of veterinary biological products, and in particular relates to a traditional Chinese medicine immune enhancer for vaccines and a preparation method and application thereof. Background technique [0002] Immunopotentiators can activate one or more immunocompetent cells, enhance the body's specific and non-specific immune functions, and restore low immune functions to normal; enhance the immunogenicity of antigens used in combination with them, and accelerate the induction of immune responses; some The traditional Chinese medicine immune enhancer used in vaccines has a two-way regulating effect on the immune function of the body, so that the immune function that is too high or too low tends to be normal. [0003] Classical swine fever virus (CSFV) is a highly contagious disease caused by classical swine fever virus (CSFV), which can infect pigs of different ages, sexes and breeds, with a mortality rate as high as 80-90...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K31/715A61K31/496A61P37/04A61P31/14A61K39/187
Inventor 王彦辉郜水菊张凤华姬普雨郭文英李黎刘济坤姬星宇孙少辉房大学乔云龙胡玉胜李自波焦金英李国辉郭平霞
Owner 商丘美兰生物工程有限公司
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