Ganmaoling granules and preparation method thereof

A technology of Ganmaoling and granules, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems affecting quality and curative effect, deliquescence, softening and deterioration of Ganmaoqingre granules, etc. Achieve the effect of pneumonia inhibition and death protection, low hygroscopicity, and internal quality improvement

Active Publication Date: 2018-02-09
GUANGDONG YILI GROUP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Ganmao Qingre Granules are prone to deliquescence, softening and deterioration during long-term storage, which affects its quality and curative effect

Method used

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  • Ganmaoling granules and preparation method thereof
  • Ganmaoling granules and preparation method thereof
  • Ganmaoling granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 A Ganmaoling Granule

[0032] Described Ganmaoling granules consist of the following components and parts by weight thereof:

[0033] 450 parts of Sanchaku, 300 parts of calendula silver plate, 200 parts of wild chrysanthemum, 700 parts of gang plum, 15 parts of acetaminophen, 0.1 part of chlorpheniramine maleate, 0.2 part of caffeine, 0.1 part of peppermint oil, lactose 200 parts, 100 parts of demyelinated starch, 60 parts of microcrystalline cellulose, 5 parts of β-cyclodextrin, 3 parts of polyvinylpyrrolidone and 80 parts of ethanol.

[0034] The preparation method of described debranched starch is:

[0035] (1) Take 1g of cornstarch, add it to 10mL of water, stir evenly, heat in a water bath to 60°C, stir and add 50mL of dimethyl sulfoxide, heat to boiling, and boil for 1 hour to obtain a solution;

[0036] (2) Cool the solution obtained in step (1) to room temperature, add 6 times its volume of ethanol, and centrifuge to obtain a precipitate;

[0037] ...

Embodiment 2

[0044] Example 2 A Ganmaoling Granule

[0045] Described Ganmaoling granules consist of the following components and parts by weight thereof:

[0046] 490 parts of Sanchaku, 325 parts of calendula silver plate, 250 parts of wild chrysanthemum, 740 parts of gang plum, 20 parts of acetaminophen, 0.4 part of chlorpheniramine maleate, 0.4 part of caffeine, 0.2 part of peppermint oil, lactose 250 parts, 150 parts of amylopectin, 90 parts of microcrystalline cellulose, 7.5 parts of β-cyclodextrin, 4 parts of polyvinylpyrrolidone and 100 parts of ethanol.

[0047] The preparation method of the debranched starch is similar to Example 1.

[0048] Preparation:

[0049] S1 Mix Sanchaku, Marigold Silver Plate, Wild Chrysanthemum, and Gangmei evenly to obtain medicinal materials;

[0050] S2 Add 7 times the weight of water to the medicinal material obtained in step S1, decoct twice for 2.5 hours each time, combine the decoction, filter, concentrate under reduced pressure, and spray dry to...

Embodiment 3

[0054] Example 3 A Ganmaoling Granule

[0055] Described Ganmaoling granules consist of the following components and parts by weight thereof:

[0056] 530 parts of Sanchaku, 350 parts of calendula silver plate, 300 parts of wild chrysanthemum, 780 parts of gang plum, 25 parts of acetaminophen, 0.7 part of chlorpheniramine maleate, 0.6 part of caffeine, 0.3 part of peppermint oil, lactose 300 parts, 200 parts of demyelinated starch, 120 parts of microcrystalline cellulose, 10 parts of β-cyclodextrin, 5 parts of polyvinylpyrrolidone and 120 parts of ethanol.

[0057] The preparation method of the debranched starch is similar to Example 1.

[0058] Preparation:

[0059] S1 Mix Sanchaku, Marigold Silver Plate, Wild Chrysanthemum, and Gangmei evenly to obtain medicinal materials;

[0060] S2 Add 8 times the weight of water to the medicinal material obtained in step S1, decoct twice for 3 hours each time, combine the decoction, filter, concentrate under reduced pressure, and spra...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to ganmaoling granules and a preparation method thereof. The ganmaoling granules include, by weight parts, 450-530 parts of evodia lepta, 300-350 parts of spanishneedles herb, 200-300 parts of wild chrysanthemum, 700-780 parts of holly root, 15-25 parts of acetaminophen, 0.1-0.7 parts of chlorpheniramine maleate, 0.2-0.6 part of caffeine, 0.1-0.3 part of peppermint oil, 200-300 parts of lactose, 100-200 parts of debranched starch, 60-120 parts of microcrystalline cellulose, 5-10 parts of beta-cyclodextrin, 3-5 parts of polyvinylpyrrolidone and 80-120 parts of ethanol. The ganmaoling granules prepared by the method have low hygroscopicity, are easy to disintegrate, have high bioavailability, good stability and high safety, and have significant effects on the inhibition of pneumonia and death protection of influenza virus-infected mice.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a Ganmaoling granule and a preparation method thereof. Background technique [0002] Cold is a common disease. The main symptoms are headache, fever, cough, nasal congestion, sore throat, etc., which have a certain impact on work and life, and even cause complications, which are life-threatening. Common dosage forms of existing cold medicines Granules, capsules, tablets, etc. Ganmaoling Granules is a well-known large variety of cold medicine in China. It is a Chinese patent medicine composed of four traditional Chinese medicines such as Sanchaku, Wild Chrysanthemum, Gangmei, and Calendula Yinpan, as well as three chemical medicines. It is a model of combining traditional Chinese and Western medicine to treat diseases. Ganmaoling has antipyretic and analgesic effects, and is clinically used to treat headache, fever, nasal congestion, runny nose, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/16A61K47/36A61K47/26A61K47/38A61K47/69A61P11/00A61K31/522A61K31/4402A61K31/167
CPCA61K9/1623A61K9/1652A61K31/167A61K31/4402A61K31/522A61K36/185A61K36/28A61K36/287A61K36/534A61K36/754A61K2236/331A61K2236/39A61K2236/51
Inventor 曾胜曾佐达梁烽焱张浩潘洁丽
Owner GUANGDONG YILI GROUP PHARMA
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