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A kind of preparation method of single herb medicine pellet

A technology of single herbal medicine and pellets, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. Unstable release and other issues, to achieve stable drug efficacy, improve drug compliance, and facilitate taking effects

Active Publication Date: 2021-06-11
河南泓医药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high viscosity of traditional Chinese medicine or herbal medicine dry paste, most of the traditional granule preparation methods have problems such as low drug loading, unsightly appearance, bitter taste, easy moisture absorption, unstable drug release, and low utilization rate of medicinal materials.
The invention patent with the application publication number of CN1386495A on the processing method and technology of Chinese medicine ultrafine particles discloses a processing method of traditional Chinese medicine ultrafine particles. To meet the needs of dialectical treatment of traditional Chinese medicine, it can be modified and tailored according to the symptoms, and the formula is flexible. It does not need to be boiled when used. It can be taken directly by soaking in boiling water for about 3 to 20 minutes. It not only maintains the nature, taste and function of traditional Chinese medicine, but also avoids It saves the trouble of decocting, is convenient for patients to take, and is economical, hygienic, fast and convenient. However, the content of Chinese medicine ingredients in ultrafine particles prepared from the same Chinese medicine in different regions or different batches is quite different.

Method used

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  • A kind of preparation method of single herb medicine pellet
  • A kind of preparation method of single herb medicine pellet
  • A kind of preparation method of single herb medicine pellet

Examples

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Comparison scheme
Effect test

Embodiment 1

[0027] The preparation method of the honeysuckle pellet of the present embodiment, comprises the following steps:

[0028] 1) Preparation of honeysuckle powder: take fresh honeysuckle, wash it, crush it as appropriate, homogenate it into a paste, add water twice the mass of fresh honeysuckle, put it into a heated ultrasonic wall breaking tank, heat to 40°C, and Sonicate at 26 kHz for 50 minutes to break the cell walls of fresh honeysuckle; then filter, and dry the filtrate at 55° C. for 13 hours in the far infrared. After drying, pulverize and pass through a 200-mesh sieve to obtain honeysuckle powder.

[0029] 2) Blending honeysuckle powder: take 15 batches of fresh honeysuckle, including the same kind of representative medicinal materials collected from different production areas and in different seasons. Step 1) honeysuckle powder preparation method was adopted to obtain honeysuckle powder, and the contents of chlorogenic acid and luteolin were measured by the content deter...

Embodiment 2

[0046] The preparation method of the honeysuckle pellet of the present embodiment, comprises the following steps:

[0047] 1) Preparation of honeysuckle powder: take fresh honeysuckle, wash it, crush it as appropriate, homogenate it into a paste, add water twice the mass of fresh honeysuckle, put it into a heated ultrasonic wall breaking tank, heat to 60°C, and Sonicate at 60 kHz for 30 minutes to break the cell walls of fresh honeysuckle; then filter, and dry the filtrate at 55° C. for 13 hours in the far infrared. After drying, crush and pass through a 150-mesh sieve to obtain honeysuckle powder.

[0048] 2) Blending honeysuckle powder: take 15 batches of fresh honeysuckle, including the same kind of representative medicinal materials collected from different production areas and in different seasons. Step 1) honeysuckle powder preparation method was adopted to obtain honeysuckle powder, and the contents of chlorogenic acid and luteolin were measured by the content determina...

Embodiment 3

[0058] The preparation method of the notoginseng pellet of the present embodiment, comprises the following steps:

[0059] 1) Preparation of Panax notoginseng powder: take fresh Panax notoginseng, wash it, break it into pieces, homogenize it into a paste, add ethanol twice the mass of fresh Sanqi into a heated ultrasonic wall breaking tank and heat to 30°C. And under the condition of 80kHz ultrasonic treatment for 90min, the cells of fresh Panax notoginseng were broken; then filtered, the filtrate was dried at a temperature of 45°C under vacuum conditions, pulverized after drying, and passed through a 200-mesh sieve to obtain three Seven powder;

[0060] 2) Blending Panax notoginseng powder: Take 15 batches of fresh Panax notoginseng, including the same representative medicinal material collected from different production areas and in different seasons. Adopt step 1) Radix Notoginseng powder preparation method, obtain Radix Notoginseng powder, adopt " Chinese Pharmacopoeia " ...

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Abstract

The present invention relates to a kind of single medicine pellet and its preparation method, comprising the following steps: taking fresh medicine, washing or drying medicine, breaking, ultrasonic treatment, filtering, drying, pulverizing to obtain medicine powder; taking different batches Medicinal material, prepare medicinal material powder, measure the average value of component content, and batch blend to obtain medicinal material raw material powder; take fresh medicinal material, wash or dry medicinal material, add solvent, ultrasonically assisted extraction twice, filter, combine filtrate, concentrate into infusion Ointment, dried into powder to obtain dry ointment powder; take different batches of medicinal materials to make dry ointment powder, measure the average value of the component content, and batch blend to obtain dry ointment raw material powder; mix medicinal material raw material powder or dry ointment raw material powder or The powder is mixed with the raw material powder of the dry paste, and the binder is added to make micropills. The method has the advantages of high yield and cost saving, and the prepared single herb pellets are free of decoction, easy to carry, uniform in composition, and stable and reliable in curative effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a method for preparing single herbal medicine pellets. Background technique [0002] Pellets, also known as small pills, refer to small spherical oral dosage forms with a diameter of about 1mm, generally no more than 2.5mm. In ancient my country, there were single drug pellet preparations, such as "Liushen Pill", "Louyan Pill", "Niuhuang Xiaoyan Pill", etc., but these pellets are mostly limited to the application of small prescription doses and drugs for treating throat inflammation, and the preparation process is backward , there are disadvantages such as high work intensity and low efficiency. With the development of modern pharmacy, it has been found that compared with other oral preparations, micropill preparations have many advantages. For example, a dose is composed of multiple dispersion units, which can be dispersed in a large area and ev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K36/355A61K47/10
CPCA61K9/5031A61K36/355
Inventor 王世峰荆晓玉
Owner 河南泓医药业有限公司
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