A kind of preparation method of single herb medicine pellet

Abstract

The present invention relates to a kind of single medicine pellet and its preparation method, comprising the following steps: taking fresh medicine, washing or drying medicine, breaking, ultrasonic treatment, filtering, drying, pulverizing to obtain medicine powder; taking different batches Medicinal material, prepare medicinal material powder, measure the average value of component content, and batch blend to obtain medicinal material raw material powder; take fresh medicinal material, wash or dry medicinal material, add solvent, ultrasonically assisted extraction twice, filter, combine filtrate, concentrate into infusion Ointment, dried into powder to obtain dry ointment powder; take different batches of medicinal materials to make dry ointment powder, measure the average value of the component content, and batch blend to obtain dry ointment raw material powder; mix medicinal material raw material powder or dry ointment raw material powder or The powder is mixed with the raw material powder of the dry paste, and the binder is added to make micropills. The method has the advantages of high yield and cost saving, and the prepared single herb pellets are free of decoction, easy to carry, uniform in composition, and stable and reliable in curative effect.

Description

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a method for preparing single herbal medicine pellets. Background technique

[0002] Pellets, also known as small pills, refer to small spherical oral dosage forms with a diameter of about 1mm, generally no more than 2.5mm. In ancient my country, there were single drug pellet preparations, such as "Liushen Pill", "Louyan Pill", "Niuhuang Xiaoyan Pill", etc., but these pellets are mostly limited to the application of small prescription doses and drugs for treating throat inflammation, and the preparation process is backward , there are disadvantages such as high work intensity and low efficiency. With the development of modern pharmacy, it has been found that compared with other oral preparations, micropill preparations have many advantages. For example, a dose is composed of multiple dispersion units, which can be dispersed in a large area and ev...

Examples

Embodiment 1

[0027] The preparation method of the honeysuckle pellet of the present embodiment, comprises the following steps:

[0028] 1) Preparation of honeysuckle powder: take fresh honeysuckle, wash it, crush it as appropriate, homogenate it into a paste, add water twice the mass of fresh honeysuckle, put it into a heated ultrasonic wall breaking tank, heat to 40°C, and Sonicate at 26 kHz for 50 minutes to break the cell walls of fresh honeysuckle; then filter, and dry the filtrate at 55° C. for 13 hours in the far infrared. After drying, pulverize and pass through a 200-mesh sieve to obtain honeysuckle powder.

[0029] 2) Blending honeysuckle powder: take 15 batches of fresh honeysuckle, including the same kind of representative medicinal materials collected from different production areas and in different seasons. Step 1) honeysuckle powder preparation method was adopted to obtain honeysuckle powder, and the contents of chlorogenic acid and luteolin were measured by the content deter...

Embodiment 2

[0046] The preparation method of the honeysuckle pellet of the present embodiment, comprises the following steps:

[0047] 1) Preparation of honeysuckle powder: take fresh honeysuckle, wash it, crush it as appropriate, homogenate it into a paste, add water twice the mass of fresh honeysuckle, put it into a heated ultrasonic wall breaking tank, heat to 60°C, and Sonicate at 60 kHz for 30 minutes to break the cell walls of fresh honeysuckle; then filter, and dry the filtrate at 55° C. for 13 hours in the far infrared. After drying, crush and pass through a 150-mesh sieve to obtain honeysuckle powder.

[0048] 2) Blending honeysuckle powder: take 15 batches of fresh honeysuckle, including the same kind of representative medicinal materials collected from different production areas and in different seasons. Step 1) honeysuckle powder preparation method was adopted to obtain honeysuckle powder, and the contents of chlorogenic acid and luteolin were measured by the content determina...

Embodiment 3

[0058] The preparation method of the notoginseng pellet of the present embodiment, comprises the following steps:

[0059] 1) Preparation of Panax notoginseng powder: take fresh Panax notoginseng, wash it, break it into pieces, homogenize it into a paste, add ethanol twice the mass of fresh Sanqi into a heated ultrasonic wall breaking tank and heat to 30°C. And under the condition of 80kHz ultrasonic treatment for 90min, the cells of fresh Panax notoginseng were broken; then filtered, the filtrate was dried at a temperature of 45°C under vacuum conditions, pulverized after drying, and passed through a 200-mesh sieve to obtain three Seven powder;

[0060] 2) Blending Panax notoginseng powder: Take 15 batches of fresh Panax notoginseng, including the same representative medicinal material collected from different production areas and in different seasons. Adopt step 1) Radix Notoginseng powder preparation method, obtain Radix Notoginseng powder, adopt " Chinese Pharmacopoeia " ...

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a method for preparing single herbal medicine pellets. Background technique

[0002] Pellets, also known as small pills, refer to small spherical oral dosage forms with a diameter of about 1mm, generally no more than 2.5mm. In ancient my country, there were single drug pellet preparations, such as "Liushen Pill", "Louyan Pill", "Niuhuang Xiaoyan Pill", etc., but these pellets are mostly limited to the application of small prescription doses and drugs for treating throat inflammation, and the preparation process is backward , there are disadvantages such as high work intensity and low efficiency. With the development of modern pharmacy, it has been found that compared with other oral preparations, micropill preparations have many advantages. For example, a dose is composed of multiple dispersion units, which can be dispersed in a large area and ev...

Examples

Embodiment 1

[0027] The preparation method of the honeysuckle pellet of the present embodiment, comprises the following steps:

[0028] 1) Preparation of honeysuckle powder: take fresh honeysuckle, wash it, crush it as appropriate, homogenate it into a paste, add water twice the mass of fresh honeysuckle, put it into a heated ultrasonic wall breaking tank, heat to 40°C, and Sonicate at 26 kHz for 50 minutes to break the cell walls of fresh honeysuckle; then filter, and dry the filtrate at 55° C. for 13 hours in the far infrared. After drying, pulverize and pass through a 200-mesh sieve to obtain honeysuckle powder.

[0029] 2) Blending honeysuckle powder: take 15 batches of fresh honeysuckle, including the same kind of representative medicinal materials collected from different production areas and in different seasons. Step 1) honeysuckle powder preparation method was adopted to obtain honeysuckle powder, and the contents of chlorogenic acid and luteolin were measured by the content deter...

Embodiment 2

[0046] The preparation method of the honeysuckle pellet of the present embodiment, comprises the following steps:

[0047] 1) Preparation of honeysuckle powder: take fresh honeysuckle, wash it, crush it as appropriate, homogenate it into a paste, add water twice the mass of fresh honeysuckle, put it into a heated ultrasonic wall breaking tank, heat to 60°C, and Sonicate at 60 kHz for 30 minutes to break the cell walls of fresh honeysuckle; then filter, and dry the filtrate at 55° C. for 13 hours in the far infrared. After drying, crush and pass through a 150-mesh sieve to obtain honeysuckle powder.

[0048] 2) Blending honeysuckle powder: take 15 batches of fresh honeysuckle, including the same kind of representative medicinal materials collected from different production areas and in different seasons. Step 1) honeysuckle powder preparation method was adopted to obtain honeysuckle powder, and the contents of chlorogenic acid and luteolin were measured by the content determina...

Embodiment 3

[0058] The preparation method of the notoginseng pellet of the present embodiment, comprises the following steps:

[0059] 1) Preparation of Panax notoginseng powder: take fresh Panax notoginseng, wash it, break it into pieces, homogenize it into a paste, add ethanol twice the mass of fresh Sanqi into a heated ultrasonic wall breaking tank and heat to 30°C. And under the condition of 80kHz ultrasonic treatment for 90min, the cells of fresh Panax notoginseng were broken; then filtered, the filtrate was dried at a temperature of 45°C under vacuum conditions, pulverized after drying, and passed through a 200-mesh sieve to obtain three Seven powder;

[0060] 2) Blending Panax notoginseng powder: Take 15 batches of fresh Panax notoginseng, including the same representative medicinal material collected from different production areas and in different seasons. Adopt step 1) Radix Notoginseng powder preparation method, obtain Radix Notoginseng powder, adopt " Chinese Pharmacopoeia " ...

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