Application of astilbin in preparing medicine for treating gastric cancer

A technology for astilbin and gastric cancer, which is applied to the application field of astilbin in the preparation of a drug for the treatment of gastric cancer, can solve the problems of insignificant treatment effect, low treatment compliance, small toxic and side effects, etc., so as to enhance the immune function and effect of the body Good and quick results

Inactive Publication Date: 2018-03-30
珠海霍普金斯医药研究院股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, Western medicine is used to treat gastric cancer clinically. Although it can achieve a certain therapeutic effect to a certain extent, it has relatively large toxic and side effects and low treatment compliance. Traditional Chinese medicine is used to treat gastric cancer. The effect is not obvious, and it has little effect on improving the patient's quality of life and prolonging the survival period

Method used

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  • Application of astilbin in preparing medicine for treating gastric cancer
  • Application of astilbin in preparing medicine for treating gastric cancer
  • Application of astilbin in preparing medicine for treating gastric cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Astilbin inhibits the proliferation of human gastric cancer cell line MKN-45 in vitro

[0021] Human gastric cancer cell line MKN-45 cells were cultured in a cell culture box with IMDM medium containing 10% fetal bovine serum. When the cells grow well and the walls of the cell culture flask are basically covered, the cells are digested, 100μL of the cell suspension is inoculated into a 96-well plate at a concentration of 1×106 / L, and then divided into a model group and a cyclophosphamide high-concentration group (cyclophosphate Amide 10-6mol / L), cyclophosphamide low concentration group (10-8mol / L), astilbin high concentration group (10-5mol / L), astilbin low concentration group (10-7mol / L), Make 5 holes for each concentration group. After 48 hours of incubation, the cell supernatant was collected, and after centrifugation, the survival rate of MKN-45 cells was detected according to the instructions of the MTT kit.

[0022] The experimental results are shown in Table 1. The...

Embodiment 2

[0027] Astilbin inhibits tumor growth of human gastric cancer cell line MKN-45 in vivo

[0028] Take the human gastric cancer cell line MKN-45 in the logarithmic growth phase, and adjust the cell concentration to 1×10 after washing with PBS 7 / mL, used to inoculate immunodeficient mice. Take 40 BALB / c female nude mice, and inoculate 5×10 tumor cells in the shoulder blades of each mouse 6 Each, wait for the tumor to grow to 100mm 3 Later, they were randomly divided into 5 groups, namely cyclophosphamide high-dose group (24mg / kg), cyclophosphamide low-dose group (12mg / kg), astilbin high-dose group (200mg / kg), astilbin low-dose group Dose group (50mg / kg) and model group. Gavage was given once a day, and the model group was given the same volume of drinking water by gavage for 2 weeks. The tumor volume was measured twice a week, and the mouse body weight was measured at the end of the experiment.

[0029] The experimental results are shown in Table 2 and Table 3. The tumor growth is ...

Embodiment 3

[0037] Zhou, male, 57 years old, suffered from stomach problems for 2 years. His symptoms included upper abdominal discomfort and fullness, loss of appetite, often accompanied by nausea, belching, acid reflux and vomiting, and occasionally hematemesis. He was diagnosed as stomach cancer by the hospital. 2g of astilbin was taken in 2 doses, 4 weeks as a course of treatment. After 3 courses of treatment, the appetite improved, the body became stronger, and the patient's stomach pain, nausea, vomiting, and vomiting were gradually relieved. After 6 consecutive courses of treatment, all symptoms disappeared, the tumor no longer exists, and everything is normal.

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Abstract

The invention relates to new application of astilbin, and in particular to application of the astilbin in preparing medicine for treating gastric cancer. The astilbin is capable of improving symptomsof fullness in stomach, indigestion and loss of appetite, body tired fatigue and the like related to the gastric cancer. The astilbin has a good effect in treating the gastric cancer, fast effect is achieved, the body immune function can be enhanced, the survival quality of a patient is increased, and the survival period can also be prolonged to different degrees; clinically, the astilbin has no any toxic and side effects, and raw materials are non-toxic, so that the compliance of treatment can be increased; the raw materials are easy to obtain, the astilbin is suitable for being widely used,and a very good application prospect is obtained.

Description

Technical field [0001] The invention relates to a new use of astilbin, in particular to the application of astilbin in the preparation of medicines for treating gastric cancer. Background technique [0002] Gastric cancer is a malignant tumor that originates from the epithelium of the gastric mucosa. It ranks first among various malignant tumors in my country. There are obvious regional differences in the incidence of gastric cancer. The incidence of gastric cancer in the northwest and east coastal areas of my country is significantly higher than that in the south. . The prevalent age is over 50 years old, and the ratio of male to female incidence is 2:1. Due to changes in diet, increased work pressure, and Helicobacter pylori infection, gastric cancer tends to be younger. Gastric cancer can occur in any part of the stomach, and more than half of them occur in the antrum. The greater curvature of the stomach, the lesser curvature, and the front and back walls can be affected. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P35/00A61P1/14A61P39/00
CPCA61K31/7048
Inventor 曹文强赵柏松
Owner 珠海霍普金斯医药研究院股份有限公司
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