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A method for dynamic measurement of oxygen uptake rate

A technology for oxygen uptake rate and dynamic measurement, which is used in measurement devices, measurement of magnetic variables, magnetic resonance measurement, etc., can solve problems such as the inability to meet the requirements of time resolution, and achieve the effect of saving time and cost

Active Publication Date: 2019-11-29
PEKING UNIV
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Problems solved by technology

Therefore, GESSE imaging technology cannot meet the time resolution requirements of OEF dynamic measurement

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  • A method for dynamic measurement of oxygen uptake rate
  • A method for dynamic measurement of oxygen uptake rate
  • A method for dynamic measurement of oxygen uptake rate

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Embodiment Construction

[0032] In order to make the features of the present invention easier to understand, representative preferred embodiments are adopted below and described in detail with the accompanying drawings. It should be noted that the present invention is not limited to the specific structures, functions, devices and methods described, and may also have other implementations, or a combination of other implementations. The number of elements described in the present invention may also be set to a plurality. Furthermore, some technical features and details that are well known in the art are not described in order to avoid obscuring the present invention with other examples.

[0033] The present invention provides a new sequence of spin echo-echo plane imaging based on multiple time offsets, named MOSE-EPI (Multiple-Offset-Spin-Echo Echo-Planar Imaging). Because of its high temporal resolution, this sequence can be used in functional Magnetic Resonance Imaging (fMRI) research. In this exam...

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Abstract

The invention discloses a method for dynamically measuring an oxygen extraction fraction (OEF), an acquisition mode based on echo planar imaging is adopted, i.e., an acquisition mode of exciting and utilizing an echo chain formed by multi-gradient forward and reverse direction rapid switching once to fill K space in one time, so that time resolution is greatly improved, multi-offset-spin-echo imaging is utilized to measure change of an MR signal in a tissue, and later dynamic measurement of the OEF is realized through a relation between the change and tissue OEF. The method for dynamically measuring the OEF solves the problem of relatively long acquisition time of a traditional scanning sequence GESSE caused by the acquisition mode, the time resolution of OED measurement is greatly improved, and it is hopeful to study physiological change from a new angle of view and promote development of neuroscience and clinical medicine.

Description

technical field [0001] The invention relates to the field of magnetic resonance imaging, in particular to a method for dynamically measuring oxygen uptake rate. Background technique [0002] Oxygen Extraction Fraction (OEF) describes the amount of oxygen taken up by tissues from the blood when blood flows through the capillary bed, that is, the ratio of oxygen consumption to oxygen supply. The main energy required for organ activity comes from aerobic metabolism, so OEF can directly reflect organ sustainability and activity, and is an important marker of organ health and function. In terms of clinical application, OEF is used to study diseases related to oxygen consumption such as cerebral infarction, tumor, senile dementia, cerebral ischemia, anemia, etc. In cognitive neuroscience, the study of OEF in functional stimulation will help to understand the activity process between related brain regions and specific psychological stages. Therefore, the study of dynamic measureme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01R33/54G01R33/561G01R33/563
CPCG01R33/543G01R33/561G01R33/5613G01R33/56308
Inventor 高家红殷雅彦
Owner PEKING UNIV
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