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A molecular marker miR-423-5p for predicting lung cancer brain metastasis and applications thereof in medicines and a diagnostic kit

A molecular marker, brain metastasis technology, applied in the field of molecular biology, can solve the problem of difficult early detection of brain metastasis, and achieve the effect of clarifying the occurrence of brain metastasis, inhibiting clinical efficacy, and clarifying clinical efficacy

Inactive Publication Date: 2018-04-17
唐山市人民医院
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Problems solved by technology

[0009] In order to solve the current technical problem that the early detection of brain metastases in patients with non-small cell lung cancer is difficult, and the risk of brain metastases in patients with non-small cell lung cancer cannot be effectively detected by molecular level detection, the present invention provides a molecular marker for predicting brain metastases of lung cancer miR- 423-5p and its application in medicine and diagnostic kit

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  • A molecular marker miR-423-5p for predicting lung cancer brain metastasis and applications thereof in medicines and a diagnostic kit
  • A molecular marker miR-423-5p for predicting lung cancer brain metastasis and applications thereof in medicines and a diagnostic kit
  • A molecular marker miR-423-5p for predicting lung cancer brain metastasis and applications thereof in medicines and a diagnostic kit

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Embodiment Construction

[0043] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but the embodiments do not constitute any limitation to the present invention.

[0044] The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0045] The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0046] The experimental methods for the specific conditions not indicated in the examples are generally conventional methods in the art.

[0047] The detection methods involved in this example include microRNA probe design, extraction, qRT-PCR verification, cell proliferation, colony formation, invasion and metastasis experiments, nude mice subcutaneous tumor transplantation and metastatic tumor treatment experiments. In future clinical applications, only microRNA extraction and qRT-PCR will be used. These two methods are rou...

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Abstract

The invention belongs to the technical field of molecular biology, and discloses a molecular marker miR-423-5p for predicting lung cancer brain metastasis and applications thereof in medicines and a diagnostic kit. The application of the miR-423-5p in preparation of the tumor-inhibiting medicine, the application the miR-423-5p in preparation of a medicine inhibiting lung cancer brain metastasis, and the application of the miR-423-5p in preparation of the diagnostic kit used for predicting brain metastasis of non-small cell lung cancer are disclosed. By utilization of a molecular biological technique, molecular-level detection can be effectively performed to determine a mark for brain metastasis in patients with non-small cell lung cancer and a mark for targeted treatment, thus providing disease treatment for individuals with convenience. The molecular marker is of great guiding significance for subsequent clinical research.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and in particular relates to a group of molecular markers miR-423-5p for predicting brain metastases of lung cancer and its application in medicine and diagnostic kits. Background technique [0002] Worldwide, lung cancer is the leading cause of cancer death. Non-small cell lung cancer accounts for about 80% of all lung cancers, and about 25% of non-small cell lung cancer patients will develop brain metastases. Locally advanced non-small cell lung cancer accounts for about 40% of non-small cell lung cancer, and brain metastasis is one of the most common failures after comprehensive treatment of locally advanced non-small cell lung cancer. The risk of brain metastases in patients with early-stage NSCLC is 10%. However, locally advanced NSCLC has a high risk of brain metastases, about 30-50%. Brain metastases seriously endanger the survival and quality of life of patients. Advances in...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/136C12Q2600/158C12Q2600/178
Inventor 孙国贵胡万宁
Owner 唐山市人民医院
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