33 results about "Treat to target" patented technology

A device is provided that allows for target treatment of infections, caused by dermatophytes, yeast fungus, and mould fungus, such as onychomycosis and dermatophytosis. The device comprises a nitric oxide (NO) eluting polymer arranged to contact the infected area, such that a therapeutic dose of nitric oxide is eluted from said nitric oxide eluting polymer to said area. The nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of said therapeutic dosage of nitric oxide (NO). Furthermore, a corresponding manufacturing method is provided.

Methods and devices for the regulation of matrix metalloproteinase gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for reduction of matrix metalloproteinase gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate matrix metalloproteinase gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, cartilage defects, and tumor metastasis.

A device that is connectable to a phototherapy apparatus for applying targeted phototherapy to an area of skin to place a skin condition into remission and a method of determining a maximum tolerable dose of phototherapy applied to a treatment area to determine an optimum therapeutic dose to quickly place a skin condition into remission. The dosimetry device can include a housing and an optical matrix arranged within the housing. The optical matrix includes a plurality of at least one of absorptive, reflective and / or partially transmissive regions that each permits a different percentage of light to be delivered to an individual's skin. An assessment can then be made as to the maximum tolerable dose of phototherapy that can be applied to the individual's skin in order to place a skin condition into remission.

The invention relates to novel homopiperazine acethydrazide derivatives as shown in formula I or formula II, signs in the formulas are defined as the specification. The invention also relates to a method for preparing the homopiperazine acethydrazide derivatives, and applications of the homopiperazine acethydrazide derivatives in preparation of medicaments for treating and / or preventing tumor and / or cancer, and the medicaments comprise medicinal compositions of the homopiperazine acethydrazide derivatives. The homopiperazine acethydrazide derivatives have effective tumor activity resistance, and can be particularly used for target treatment and / or lung cancer, leucocythemia and liver cancer.

The invention discloses a medicinal composition used for treating or preventing cerebrovascular disease and related diseases. The composition comprises the following components in parts by weight: 1-50 parts of DHA (docosahexaenoic acid), 1-50 parts ofbreviscapine, 20-50 parts of and 1-10 parts of hirudin. The composition also comprises effective amount of human fat stem cell which is taken as a carrier for the medicinal composition, thus treatment medicine smoothly penetrates through a blood brain barrier, and the effect of targeted treatment on the cerebrovascular disease and related diseases is achieved. The medicinal composition disclosed by the invention can effectively improve diseases such as attack, infarction and embolism which are caused by ischemia of the brain, can effectively inhibit thrombus from being formed in human body and has good curative effect on senile dementia caused by the cerebrovascular disease, namely presenile dementia.

The invention relates to an inflammation targeted compound, a preparation method and application thereof, and belongs to the technical field of pharmacy. The compound comprises a part A and a part B, wherein the part A is inflammation related cells the number of which is 1*10<5>-1*10<8>; the part B is a treatment medicine, and the dosage is clinically acceptable effective treatment dosage. According to the preparation method, a cell-medicine compound is formed after the treatment medicines and a monocyte or neutrophil are incubated in vivo, is applied to the affected host, and is recruited to pathological part in the recruitment of inflammatory reactions of tumors, rheumatoid arthritis or atherosclerosis, so that targeted treatment to the diseases can be realized.

The invention discloses application of IGFBP3 (insulin-like growth factor-binding protein 3) in the preparation of products to diagnose type I neurofibromatosis with spinal deformity. Related markersIGFBP3 for NF1 with spinal deformity are acquired by screening via transcriptome sequencing; the role of IGFBP3 in genesis and development of bone healing defects in NF1 with spinal deformity is explored, and the acting mechanism of IGFBP3 is given to play; IGFBP3 as a novel biomarker of NF1 with spinal deformity provides important theoretical basis for early clinical intervention and targeted treatment of NF1 with spinal deformity.

The invention belongs to the technical field of molecular biology, and discloses a molecular marker miR-423-5p for predicting lung cancer brain metastasis and applications thereof in medicines and a diagnostic kit. The application of the miR-423-5p in preparation of the tumor-inhibiting medicine, the application the miR-423-5p in preparation of a medicine inhibiting lung cancer brain metastasis, and the application of the miR-423-5p in preparation of the diagnostic kit used for predicting brain metastasis of non-small cell lung cancer are disclosed. By utilization of a molecular biological technique, molecular-level detection can be effectively performed to determine a mark for brain metastasis in patients with non-small cell lung cancer and a mark for targeted treatment, thus providing disease treatment for individuals with convenience. The molecular marker is of great guiding significance for subsequent clinical research.

The invention discloses a traditional Chinese medicine composition for hyperplasia of mammary glands and a preparation method of a hydrogel patch thereof. The traditional Chinese medicine composition comprises figwort root, tangerine seed, lychee seed, diverse wormwood herb, Indian iphigenia bulb, honeylocust, rhizoma corydalis, seaweed, flos caryophyllata and garden balsam, and a pharmaceutical extract of the traditional Chinese medicine composition is obtained by extraction. The preparation method of the hydrogel patch of the traditional Chinese medicine composition for the hyperplasia of the mammary glands comprises the following steps: using a framework material, a tackifier, a humectant, a preservative, a filler, a crosslinking agent, a crosslinking regulator, a pH regulator, the pharmaceutical extract and distilled water to prepare a medicine-loaded hydrogen patch matrix; and then performing coating, cutting, standing and other steps, thus obtaining the hydrogel patch. The traditional Chinese medicine composition has a target treatment role of directly delivering the pharmaceutical active ingredients to tissues with hyperplasia lesion of the mammary glands, has the long-acting sustained-release role for sustained release of the pharmaceutical active ingredients for a long time, is convenient and comfortable to use and has the advantages of no skin irritation, no allergy and the like, thereby being an ideal pharmaceutical preparation for treating the hyperplasia of the mammary glands.

The invention discloses a vesicle nano-drug loaded with a chloroquine compound as well as a preparation method and application of the vesicle nano-drug. The vesicle nano-drug loaded with the chloroquine compound is prepared by taking a polymer and a chloroquine compound as raw materials, wherein the polymer comprises a hydrophilic chain segment and a hydrophobic chain segment; a side chain of the hydrophobic chain segment is dithiolane containing a disulfide bond. According to the vesicle nano-drug loaded with the chloroquine compound disclosed by the invention, a safe and efficient macrophage-targeted nano-drug is researched and developed for treating rheumatoid arthritis; polymer vesicles are designed for efficiently loading, carrying out targeted delivery and controlling to release drug hydroxychloroquine or chloroquine, so that the enrichment of the drug in cytoplasm is improved; M1M is re-polarized to M2M, so that secretion of proinflammatory cytokines is reduced and secretion of anti-inflammatory cytokines is increased; and the drug can be used for inhibiting DC activation and also can be used for removing ROS and enriching in inflammatory joints. In-vitro and in-vivo experiment results prove that the vesicle nano-drug loaded with the chloroquine compound can be used for carrying out targeted treatment on the rheumatoid arthritis.

The invention discloses traditional Chinese medicine powder for treating hyperplasia of mammary glands and an application method. The traditional Chinese medicine powder is prepared from the followingactive pharmaceutical ingredients in parts by weight: 38-45 parts of mirabilite, 18-25 parts of rhizoma cyperi, 27-38 parts of herba taraxaci, 27-38 parts of fruit-spike of common selfheal, 18-25 parts of rhizoma bolbostemmae, 18-25 parts of rhizoma corydalis, 18-25 parts of squama manis and 27-38 parts of radix et rhizoma rheirheum officinale; a method of for preparing and using the traditionalChinese medicine powder comprises the following steps: sorting, drying and grinding the raw materials; sieving with a 80-mesh sieve and mixing uniformly; mixing with warm boiled water into paste; spreading the paste on a piece of cut nonwoven fabric; directly attaching the nonwoven fabric to a lump or pain spot of breast, wherein the nonwoven fabric is changed every 24 hours, and 21 days form a treatment course. According to the traditional Chinese medicine powder disclosed by the invention, active ingredients of the medicines are directly conveyed to the hyperplasia tissues of mammary glandssuffering lesion to realize a targeted treatment effect, and the active substances of the medicines can be slowly released for a long time; the traditional Chinese medicine powder has the advantagesof convenience and comfort in use, no stimulation or allergy to skin and the like, and is an ideal medicine for treating hyperplasia of mammary glands.

The invention described herein provides novel ampiphilic compounds that self-assemble into a hydrogel composition useful for treating wounds, including chronic wounds and diabetic wounds. The compounds of the invention have structural characteristics, such as hydrophilic and hydrophobic moieties, that enable self-assembly into discrete nanostructures, which then entangle to form the hydrogel. Also provided are methods for treating wounds.

The invention relates to a medicament for treating sequela of cerebral apoplexy and senile dementia. Natural Chinese herbal medicines are reasonably compatible and scientifically processed, in order to nourish kidney and replenish essence, nourish true potential and accept convergence; strengthen spleen and benefit vital qi, obey properties and reach yang qi, and extinguish wind and relax vein; descend turbid and discharge phlegm and blood stasis, induce resuscitation and restore consciousness, and nourish heart and quiet spirit. Yin and yang in equilibrium, and neutral five zang viscera are realized. The medicament can be applied to nerve and mental diseases as well as psychological barrier diseases. The product has good control effects for hemiplegia, paraplegia, facial paralysis, language barrier, dysphagia, cognitive disorder, urinary and fecal incontinence, dull expression, intellectual deterioration, memory loss and miscalculation as well as bad mental symptoms, depression, headache, insomnia, epilepsy, and the like, and the treatment effective rate reaches 90% or above. The medicament is processed, lipophilic properties are increased, active ingredients can easily permeate ablood cerebral barrier formed by a lipoid bilayer, targeted treatment effects are performed, effective components can be rapidly released, biological effects are performed, and curative effects are substantially improved.

This disclosure provides ALK7-binding proteins such as anti-ALK7 antibodies, and compositions and methods for making the ALK7-binding proteins. In certain embodiments the ALK7-binding proteins inhibit, or antagonize ALK7 activity. In addition, the disclosure provides compositions and methods for diagnosing and treating overweight, obesity, diabetes, overweight, obesity, type 2 diabetes, and theirassociated conditions; metabolic disorders, and other diseases or conditions that can be treated, prevented or ameliorated by targeting ALK7.

The invention relates to application of bioactive polypeptide PACAP in preparing drugs for preventing, treating or restoring cardiac trauma diseases. The bioactive polypeptide PACAP drugs can significantly prevent and relieve toxicity of radioactive cardiac traumas, the pathological change and heart function change of the radioactive cardiac traumas are repaired, and a novel sole targeted therapystrategy is provided for malignant chest tumor and radiotherapy patients with radioactive myocardial tissue traumas as features.

The disclosure generally relates to a therapeutic approach based on the stimulation of resolution of inflammation by the Formyl-Peptide Receptor 2 / Lipoxin A4 receptor (FPR2 / ALX) for the treatment of heart disease.

The invention discloses application of anemonin in the preparation of medicines for treating osteoarthritis. After a mouse with the osteoarthritis is treated by virtue of anemonin, the degradation of joint cartilages and the hypertrophy of cartilages can be restrained, and the expression quantities of MMP13 and Collagen X are reduced. According to the application, the pharmaceutical use of anemonin is broadened, a new drug for treating the osteoarthritis by preventing the degradation cartilage matrixes and the abnormal hypertrophy of cartilage cells, and diseases can be treated based on the pathogenesis of the osteoarthritis in a targeted manner; the application has a very important significance on the clinic treatment of the osteoarthritis.

The invention relates to the field of biotechnology, and provides an aptamer specifically targeting to inflammatory synovial cells of human rheumatoid arthritis (RA), wherein the aptamer has a nucleotide sequence shown as SEQ ID NO.1. The invention further provides applications of the aptamer in preparing a biological probe for identifying the inflammatory synovial cells and applications of the aptamer in preparing medicines or medicine carriers for resisting rheumatoid arthritis in a targeting manner. The aptamer has high selectivity for the inflammatory synovial cells, and the combination with hepatic cells is eliminated or weakened. The biological probe containing the aptamer can identify in-vitro human inflammatory synovial cells, such as the inflammatory synovial cells in a synovial tissue slice of an RA patient, and thus a basis is provided for the clinical diagnosis and targeting therapy of RA.

The invention discloses an improved nano traditional Chinese medicine suppository for treating chronic pelvic inflammation. The suppository is prepared by mixing active pharmaceutical ingredients with nano lipid, modifying through polyethylene glycol stearate or polyoxyl-40 stearate (S-40) and mixing in a stirrer. The invention further provides a preparation method of the traditional Chinese medicine suppository. Nano-carrier technology is introduced into traditional medicine of China, and the suppository is conducive to being comprehensive in efficacy, quick in action, supportive targeted treatment, lasting in effect and convenient to use and has great clinical application prospect.

Sweet gum (Liquidambar styraciflua L., family Hamamelidaceae) fruit extract was discovered to possess potent activities against multiple targets of the PBK (phosphatidylinositide 3-kinase) pathway, especially the PI3K / Akt and mTOR pathways. At a very low concentration of 1.85 μg / ml (IC50), sweet gun extract showed the ability of simultaneously blocking the pathways of PI3K / Akt (upstream), mTOR (mammalian target of rapamycin) (downstream), as well as its downstream protein products S6K and S6. It was also able to block 5-HETE, a lipoxygenase product that contributes to inflammation and activation of PI3K / Akt. The sweet gum fruit extract was prepared with 50% methanol (47:1; raw to extract) and concentrated to an organic fraction (210:1 raw to extract) referred as LIS-100 via reverse-phase column chromatography using a bioassay directed fractionation approach. The extract is a new targeted therapeutic agent for numerous disorders known to be treated by mTOR inhibitors, including cancer, diabetes, obesity, and inflammation.

The invention especially relates to a medicine for local soaking type targeted treatment of meniscus injury through administration in knuckle articular cavity, belonging to the field of medical technology. The medicine comprises the following components: two ampoules of high-molecular sodium hyaluronate, wherein each ampoule has a volume of 2 ml and contains 25 mg of high-molecular sodium hyaluronate; two ampoules of lincomycin, wherein each ampoule has a volume of 5 ml and contains 0.6 g of lincomycin; two ampoules of dexamethasone, wherein each ampoule has a volume of 1 ml and contains 5 mg of dexamethasone; and one ampoule of normal saline, wherein the ampoule has a volume of 10 ml. The medicine provided by the invention is mainly prepared from high-molecular sodium hyaluronate, lincomycin, dexamethasone, normal saline and other drugs according to or partially according to certain composition and dosage; cooperatively used drugs are a non-ionic iodine contrast agent solution and a lidocaine local anesthetic; and the medicine can be organically combined with a variety of meniscus diagnosis and treatment means, is simple, safe, practical and efficient, has reliable curative effect and can effectively treat meniscus injury.

The invention discloses a pharmaceutical composition for treating diabetes and its preparation method and application. The pharmaceutical composition comprises the following raw materials in parts by weight: 3-5 parts of astragalus, 2-2.5 parts of salvia miltiorrhiza, 1-2 parts of rehmannia glutinosa, 2-3 parts of bitter gourd, 1-2 parts of polygonatum, 2-3 parts of coptis, 0.5-1 part of Atractylodes macrocephala, 0.8-1.5 parts of Polygonatum, 0.5-1 part of Scutellaria baicalensis, 2-3 parts of trichosanthin, 1.5-3 parts of raw gypsum, mulberry 2‑3.5 parts of root, 2‑3.5 parts of dendrobium, 2‑4 parts of Chinese yam, 1‑2 parts of capillary, 2 parts of cash cow leaves, 1‑2 parts of cinnamon bark, 2‑3 parts of black tea, 3‑5 parts of dried potatoes, 1.5-2 parts of grape seeds, 1-1.5 parts of cheese, 2-3 parts of wheat bran, 2-2.5 parts of seaweed. The pharmaceutical composition of the present invention can control complications by invigorating the kidney and increasing resistance, activating collaterals and invigorating the heart, reducing blood pressure and removing fat; balancing body constitution by balancing cold and heat, unblocking the middle and harmonizing the body, nourishing qi and nourishing blood; , Improving insulin sensitivity to carry out targeted therapy to repair islet function; it can effectively treat diabetes, and the curative effect is significant.

The invention discloses a medicinal composition used for treating or preventing cerebrovascular disease and related diseases. The composition comprises the following components in parts by weight: 1-50 parts of DHA (docosahexaenoic acid), 1-50 parts ofbreviscapine, 20-50 parts of and 1-10 parts of hirudin. The composition also comprises effective amount of human fat stem cell which is taken as a carrier for the medicinal composition, thus treatment medicine smoothly penetrates through a blood brain barrier, and the effect of targeted treatment on the cerebrovascular disease and related diseases is achieved. The medicinal composition disclosed by the invention can effectively improve diseases such as attack, infarction and embolism which are caused by ischemia of the brain, can effectively inhibit thrombus from being formed in human body and has good curative effect on senile dementia caused by the cerebrovascular disease, namely presenile dementia.

The invention discloses a traditional Chinese medicine composition for hyperplasia of mammary glands and a preparation method of a hydrogel patch thereof. The traditional Chinese medicine composition comprises figwort root, tangerine seed, lychee seed, diverse wormwood herb, Indian iphigenia bulb, honeylocust, rhizoma corydalis, seaweed, flos caryophyllata and garden balsam, and a pharmaceutical extract of the traditional Chinese medicine composition is obtained by extraction. The preparation method of the hydrogel patch of the traditional Chinese medicine composition for the hyperplasia of the mammary glands comprises the following steps: using a framework material, a tackifier, a humectant, a preservative, a filler, a crosslinking agent, a crosslinking regulator, a pH regulator, the pharmaceutical extract and distilled water to prepare a medicine-loaded hydrogen patch matrix; and then performing coating, cutting, standing and other steps, thus obtaining the hydrogel patch. The traditional Chinese medicine composition has a target treatment role of directly delivering the pharmaceutical active ingredients to tissues with hyperplasia lesion of the mammary glands, has the long-acting sustained-release role for sustained release of the pharmaceutical active ingredients for a long time, is convenient and comfortable to use and has the advantages of no skin irritation, no allergy and the like, thereby being an ideal pharmaceutical preparation for treating the hyperplasia of the mammary glands.

The present invention is related to novel cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.

The invention discloses an application of a combination of a heat-clearing traditional Chinese medicinal composition and an antibiotic in the preparation of uterus disease treatment drugs, and especially an application in the preparation of uterine hyperemia edema and hypertrophy treatment and improvement drugs. The antibiotic is azithromycin. The active components of the heat-clearing traditional Chinese medicinal composition comprise Philippine flemingia root, Andrographis paniculata, Root of Cherokee Rose, Stem of Chinese Mahonia and Zanthoxylum dissitum Hemsl. The combination of the heat-clearing traditional Chinese medicinal composition and the antibiotic has a good targeting application in improvement of uterus hyperemia, edema and hyperplasia, and is same to a combination of Fukeqianjin Tablets and azithromycin in reduction of the thymus organ index.

The invention discloses a plaster for treating common cold, cough and fever. The plaster for treating common cold, cough and fever is prepared from the following components: edible oil, yellow lead powder, Chinese monkshood rhizome, radix angelicae sinensis, radix bletillae striatae, poria cocos, fructus forsythiae and white peony roots. The plaster for treating common cold, cough and fever provided by the invention is characterized by external use of traditional Chinese medicines for treatment, has almost no toxic or side effects, realizes targeted treatment on the focus of a disease withoutoral administration or injection and has accuracy of position and high effect-taking speed. The invention also discloses a preparation method of the plaster for treating common cold, cough and fever,and the preparation method mainly comprises the following steps: mixing, soaking, decocting, secondary decocting, cooling, molding and the like. The preparation method has the advantages of simple preparation process and short preparation time, the preparation method does not pollute the environment and more effectively stimulate the drug effect.

A biocompatible polymer to which a plurality of clot-modulating peptides (CMPs) are bound. The polymer comprises repeating units of hydrophilic monomers and display monomers to which the CMPs are bound. For example, the CMPs can be fibrin binding peptides (FBPs) that enhance clot formation by cross-linking that occurs within and between fibers by the plurality of fibrin-binding peptides during fibrin polymerization. The polymers of the invention can be used to modulate clotting in a variety of ways via multivalent display of fibrin-binding peptides and other clot-binding and clot-modulating moieties on polymer or co-polymer backbones. In addition to clot-modulating moieties, imaging agents and therapeutic agents can be conjugated to the polymers to facilitate imaging of blood flow and thrombosis, and for treatment of clotting-related disorders.

The invention discloses a Chinese medicine pill for treating esophageal cancer and a process technology. By mainly aiming at the disadvantages of modern technologies, treatment focusing on relieving both secondary and primary symptoms, strengthening the body resistance and eliminating evil and fixed-point targeted medicine use are adopted so that not only the immunity of the organism is improved, but the treatment effect for suppressing growth of cancer cells is also realized. The Chinese medicine pill for treating esophageal cancer is characterized by consisting of rhizoma paridis, blackberrylily rhizome, American ginseng, radix astragali, poria cocos, purple sal ammoniac, podophyllum hexandrum, ruddle, bear bile, calculus bovis factitius, menthol crystal, barium sulfate, colla asini and the like. Two double-layer pills for fixed-point targeted treatment are produced by applying a layered pill production technology and a clinical mechanics principle. The first pills are generally taken in morning and mainly used for opening the esophagus to guarantee food nutrition intake. The second pills are generally taken in evening to be remained at a lesion position and mainly used for killing cancer cells directionally to play the role in suppressing tumor growth and relieving pain as well as swelling.