33 results about "Treat to target" patented technology

A device is provided that allows for target treatment of infections, caused by dermatophytes, yeast fungus, and mould fungus, such as onychomycosis and dermatophytosis. The device comprises a nitric oxide (NO) eluting polymer arranged to contact the infected area, such that a therapeutic dose of nitric oxide is eluted from said nitric oxide eluting polymer to said area. The nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of said therapeutic dosage of nitric oxide (NO). Furthermore, a corresponding manufacturing method is provided.

Methods and devices for the regulation of matrix metalloproteinase gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for reduction of matrix metalloproteinase gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate matrix metalloproteinase gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, cartilage defects, and tumor metastasis.

The invention relates to novel homopiperazine acethydrazide derivatives as shown in formula I or formula II, signs in the formulas are defined as the specification. The invention also relates to a method for preparing the homopiperazine acethydrazide derivatives, and applications of the homopiperazine acethydrazide derivatives in preparation of medicaments for treating and/or preventing tumor and/or cancer, and the medicaments comprise medicinal compositions of the homopiperazine acethydrazide derivatives. The homopiperazine acethydrazide derivatives have effective tumor activity resistance, and can be particularly used for target treatment and/or lung cancer, leucocythemia and liver cancer.

The invention discloses a medicinal composition used for treating or preventing cerebrovascular disease and related diseases. The composition comprises the following components in parts by weight: 1-50 parts of DHA (docosahexaenoic acid), 1-50 parts ofbreviscapine, 20-50 parts of and 1-10 parts of hirudin. The composition also comprises effective amount of human fat stem cell which is taken as a carrier for the medicinal composition, thus treatment medicine smoothly penetrates through a blood brain barrier, and the effect of targeted treatment on the cerebrovascular disease and related diseases is achieved. The medicinal composition disclosed by the invention can effectively improve diseases such as attack, infarction and embolism which are caused by ischemia of the brain, can effectively inhibit thrombus from being formed in human body and has good curative effect on senile dementia caused by the cerebrovascular disease, namely presenile dementia.

The invention discloses application of IGFBP3 (insulin-like growth factor-binding protein 3) in the preparation of products to diagnose type I neurofibromatosis with spinal deformity. Related markersIGFBP3 for NF1 with spinal deformity are acquired by screening via transcriptome sequencing; the role of IGFBP3 in genesis and development of bone healing defects in NF1 with spinal deformity is explored, and the acting mechanism of IGFBP3 is given to play; IGFBP3 as a novel biomarker of NF1 with spinal deformity provides important theoretical basis for early clinical intervention and targeted treatment of NF1 with spinal deformity.

The invention belongs to the technical field of molecular biology, and discloses a molecular marker miR-423-5p for predicting lung cancer brain metastasis and applications thereof in medicines and a diagnostic kit. The application of the miR-423-5p in preparation of the tumor-inhibiting medicine, the application the miR-423-5p in preparation of a medicine inhibiting lung cancer brain metastasis, and the application of the miR-423-5p in preparation of the diagnostic kit used for predicting brain metastasis of non-small cell lung cancer are disclosed. By utilization of a molecular biological technique, molecular-level detection can be effectively performed to determine a mark for brain metastasis in patients with non-small cell lung cancer and a mark for targeted treatment, thus providing disease treatment for individuals with convenience. The molecular marker is of great guiding significance for subsequent clinical research.

The invention discloses a traditional Chinese medicine composition for hyperplasia of mammary glands and a preparation method of a hydrogel patch thereof. The traditional Chinese medicine composition comprises figwort root, tangerine seed, lychee seed, diverse wormwood herb, Indian iphigenia bulb, honeylocust, rhizoma corydalis, seaweed, flos caryophyllata and garden balsam, and a pharmaceutical extract of the traditional Chinese medicine composition is obtained by extraction. The preparation method of the hydrogel patch of the traditional Chinese medicine composition for the hyperplasia of the mammary glands comprises the following steps: using a framework material, a tackifier, a humectant, a preservative, a filler, a crosslinking agent, a crosslinking regulator, a pH regulator, the pharmaceutical extract and distilled water to prepare a medicine-loaded hydrogen patch matrix; and then performing coating, cutting, standing and other steps, thus obtaining the hydrogel patch. The traditional Chinese medicine composition has a target treatment role of directly delivering the pharmaceutical active ingredients to tissues with hyperplasia lesion of the mammary glands, has the long-acting sustained-release role for sustained release of the pharmaceutical active ingredients for a long time, is convenient and comfortable to use and has the advantages of no skin irritation, no allergy and the like, thereby being an ideal pharmaceutical preparation for treating the hyperplasia of the mammary glands.

The invention discloses a vesicle nano-drug loaded with a chloroquine compound as well as a preparation method and application of the vesicle nano-drug. The vesicle nano-drug loaded with the chloroquine compound is prepared by taking a polymer and a chloroquine compound as raw materials, wherein the polymer comprises a hydrophilic chain segment and a hydrophobic chain segment; a side chain of the hydrophobic chain segment is dithiolane containing a disulfide bond. According to the vesicle nano-drug loaded with the chloroquine compound disclosed by the invention, a safe and efficient macrophage-targeted nano-drug is researched and developed for treating rheumatoid arthritis; polymer vesicles are designed for efficiently loading, carrying out targeted delivery and controlling to release drug hydroxychloroquine or chloroquine, so that the enrichment of the drug in cytoplasm is improved; M1M is re-polarized to M2M, so that secretion of proinflammatory cytokines is reduced and secretion of anti-inflammatory cytokines is increased; and the drug can be used for inhibiting DC activation and also can be used for removing ROS and enriching in inflammatory joints. In-vitro and in-vivo experiment results prove that the vesicle nano-drug loaded with the chloroquine compound can be used for carrying out targeted treatment on the rheumatoid arthritis.

The invention discloses traditional Chinese medicine powder for treating hyperplasia of mammary glands and an application method. The traditional Chinese medicine powder is prepared from the followingactive pharmaceutical ingredients in parts by weight: 38-45 parts of mirabilite, 18-25 parts of rhizoma cyperi, 27-38 parts of herba taraxaci, 27-38 parts of fruit-spike of common selfheal, 18-25 parts of rhizoma bolbostemmae, 18-25 parts of rhizoma corydalis, 18-25 parts of squama manis and 27-38 parts of radix et rhizoma rheirheum officinale; a method of for preparing and using the traditionalChinese medicine powder comprises the following steps: sorting, drying and grinding the raw materials; sieving with a 80-mesh sieve and mixing uniformly; mixing with warm boiled water into paste; spreading the paste on a piece of cut nonwoven fabric; directly attaching the nonwoven fabric to a lump or pain spot of breast, wherein the nonwoven fabric is changed every 24 hours, and 21 days form a treatment course. According to the traditional Chinese medicine powder disclosed by the invention, active ingredients of the medicines are directly conveyed to the hyperplasia tissues of mammary glandssuffering lesion to realize a targeted treatment effect, and the active substances of the medicines can be slowly released for a long time; the traditional Chinese medicine powder has the advantagesof convenience and comfort in use, no stimulation or allergy to skin and the like, and is an ideal medicine for treating hyperplasia of mammary glands.

The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers and other immune disorders.

The invention described herein provides novel ampiphilic compounds that self-assemble into a hydrogel composition useful for treating wounds, including chronic wounds and diabetic wounds. The compounds of the invention have structural characteristics, such as hydrophilic and hydrophobic moieties, that enable self-assembly into discrete nanostructures, which then entangle to form the hydrogel. Also provided are methods for treating wounds.

The invention relates to a medicament for treating sequela of cerebral apoplexy and senile dementia. Natural Chinese herbal medicines are reasonably compatible and scientifically processed, in order to nourish kidney and replenish essence, nourish true potential and accept convergence; strengthen spleen and benefit vital qi, obey properties and reach yang qi, and extinguish wind and relax vein; descend turbid and discharge phlegm and blood stasis, induce resuscitation and restore consciousness, and nourish heart and quiet spirit. Yin and yang in equilibrium, and neutral five zang viscera are realized. The medicament can be applied to nerve and mental diseases as well as psychological barrier diseases. The product has good control effects for hemiplegia, paraplegia, facial paralysis, language barrier, dysphagia, cognitive disorder, urinary and fecal incontinence, dull expression, intellectual deterioration, memory loss and miscalculation as well as bad mental symptoms, depression, headache, insomnia, epilepsy, and the like, and the treatment effective rate reaches 90% or above. The medicament is processed, lipophilic properties are increased, active ingredients can easily permeate ablood cerebral barrier formed by a lipoid bilayer, targeted treatment effects are performed, effective components can be rapidly released, biological effects are performed, and curative effects are substantially improved.

This disclosure provides ALK7-binding proteins such as anti-ALK7 antibodies, and compositions and methods for making the ALK7-binding proteins. In certain embodiments the ALK7-binding proteins inhibit, or antagonize ALK7 activity. In addition, the disclosure provides compositions and methods for diagnosing and treating overweight, obesity, diabetes, overweight, obesity, type 2 diabetes, and theirassociated conditions; metabolic disorders, and other diseases or conditions that can be treated, prevented or ameliorated by targeting ALK7.

The disclosure generally relates to a therapeutic approach based on the stimulation of resolution of inflammation by the Formyl-Peptide Receptor 2/Lipoxin A₄ receptor (FPR2/ALX) for the treatment of heart disease.

The invention discloses application of anemonin in the preparation of medicines for treating osteoarthritis. After a mouse with the osteoarthritis is treated by virtue of anemonin, the degradation of joint cartilages and the hypertrophy of cartilages can be restrained, and the expression quantities of MMP13 and Collagen X are reduced. According to the application, the pharmaceutical use of anemonin is broadened, a new drug for treating the osteoarthritis by preventing the degradation cartilage matrixes and the abnormal hypertrophy of cartilage cells, and diseases can be treated based on the pathogenesis of the osteoarthritis in a targeted manner; the application has a very important significance on the clinic treatment of the osteoarthritis.

The invention especially relates to a medicine for local soaking type targeted treatment of meniscus injury through administration in knuckle articular cavity, belonging to the field of medical technology. The medicine comprises the following components: two ampoules of high-molecular sodium hyaluronate, wherein each ampoule has a volume of 2 ml and contains 25 mg of high-molecular sodium hyaluronate; two ampoules of lincomycin, wherein each ampoule has a volume of 5 ml and contains 0.6 g of lincomycin; two ampoules of dexamethasone, wherein each ampoule has a volume of 1 ml and contains 5 mg of dexamethasone; and one ampoule of normal saline, wherein the ampoule has a volume of 10 ml. The medicine provided by the invention is mainly prepared from high-molecular sodium hyaluronate, lincomycin, dexamethasone, normal saline and other drugs according to or partially according to certain composition and dosage; cooperatively used drugs are a non-ionic iodine contrast agent solution and a lidocaine local anesthetic; and the medicine can be organically combined with a variety of meniscus diagnosis and treatment means, is simple, safe, practical and efficient, has reliable curative effect and can effectively treat meniscus injury.

The invention discloses an application of a combination of a heat-clearing traditional Chinese medicinal composition and an antibiotic in the preparation of uterus disease treatment drugs, and especially an application in the preparation of uterine hyperemia edema and hypertrophy treatment and improvement drugs. The antibiotic is azithromycin. The active components of the heat-clearing traditional Chinese medicinal composition comprise Philippine flemingia root, Andrographis paniculata, Root of Cherokee Rose, Stem of Chinese Mahonia and Zanthoxylum dissitum Hemsl. The combination of the heat-clearing traditional Chinese medicinal composition and the antibiotic has a good targeting application in improvement of uterus hyperemia, edema and hyperplasia, and is same to a combination of Fukeqianjin Tablets and azithromycin in reduction of the thymus organ index.

The invention discloses a plaster for treating common cold, cough and fever. The plaster for treating common cold, cough and fever is prepared from the following components: edible oil, yellow lead powder, Chinese monkshood rhizome, radix angelicae sinensis, radix bletillae striatae, poria cocos, fructus forsythiae and white peony roots. The plaster for treating common cold, cough and fever provided by the invention is characterized by external use of traditional Chinese medicines for treatment, has almost no toxic or side effects, realizes targeted treatment on the focus of a disease withoutoral administration or injection and has accuracy of position and high effect-taking speed. The invention also discloses a preparation method of the plaster for treating common cold, cough and fever,and the preparation method mainly comprises the following steps: mixing, soaking, decocting, secondary decocting, cooling, molding and the like. The preparation method has the advantages of simple preparation process and short preparation time, the preparation method does not pollute the environment and more effectively stimulate the drug effect.