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Improved nano traditional Chinese medicine suppository for treating chronic pelvic inflammation and preparation method thereof

A technology of chronic pelvic inflammatory disease and nano-traditional Chinese medicine, which is applied in pharmaceutical formulations, suppository delivery, medical preparations with inactive ingredients, etc. Reduce toxic side effects and avoid the effect of vaginal plugs

Inactive Publication Date: 2019-09-20
深圳市福田区风湿病专科医院 +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disease is prone to recurring and protracted, which seriously affects the physical and mental health of patients, and also brings a large economic burden to individuals and society.
Among the existing medicines for treating pelvic inflammatory disease, retention enema has been clinically proven to be effective and safe, but the commonly used enema solution has problems such as troublesome operation, easy leakage of contaminated clothes, and short shelf life; meanwhile, existing medicines for treating pelvic inflammatory disease Most of them work through oral medicine, intravenous injection, and vaginal medicine. However, these usages have risks such as low availability and large adverse reactions.

Method used

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Examples

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Effect test

Embodiment

[0018] A kind of improved nano traditional Chinese medicine suppository for the treatment of chronic pelvic inflammatory disease, after mixing raw material drug and nano lipid, through stearic acid polyethylene glycol ester or polyoxyl 40 stearate (S-40) modification, then in vacuum Mixed in a blender. Wherein, the mass ratio of bulk drug to nano-lipid is 1:25, and the nano-lipid is nanoscale. After it is mixed with bulk drug, due to hydrophobic effect, bulk drug and liposome are together.

[0019] Specifically, the raw material medicine is composed of the following components by weight: 3 parts of Caulis Spatholobus, 3 parts of Patrinia, 3 parts of Dandelion, 1.5 parts of Radix Paeoniae Rubra, 1.5 parts of peach kernel, 2 parts of Salvia miltiorrhiza, each component is granular agent. Nano lipids are composed of liquid lipids, solid lipids and fat-soluble emulsifiers, wherein the liquid lipids, solid lipids and fat-soluble emulsifiers are liquid ATO888, caprylic triglyceride...

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PUM

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Abstract

The invention discloses an improved nano traditional Chinese medicine suppository for treating chronic pelvic inflammation. The suppository is prepared by mixing active pharmaceutical ingredients with nano lipid, modifying through polyethylene glycol stearate or polyoxyl-40 stearate (S-40) and mixing in a stirrer. The invention further provides a preparation method of the traditional Chinese medicine suppository. Nano-carrier technology is introduced into traditional medicine of China, and the suppository is conducive to being comprehensive in efficacy, quick in action, supportive targeted treatment, lasting in effect and convenient to use and has great clinical application prospect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an improved nanometer traditional Chinese medicine suppository for treating chronic pelvic inflammatory disease and a preparation method thereof. Background technique [0002] According to traditional Chinese medicine, chronic pelvic inflammatory disease is a common gynecological / andrological disease in clinical practice, which refers to the inflammation of the internal reproductive organs and their surrounding connective tissue and pelvic peritoneum. The category of traditional Chinese medicine is called "women's abdominal pain", "leukorrhagia" and other categories. The disease is easy to recur and persists, which seriously affects the physical and mental health of patients, and also brings a large economic burden to individuals and society. Among the existing medicines for treating pelvic inflammatory disease, retention enema is clinically proven to be ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/84A61K9/02A61P15/00
CPCA61K9/0031A61K9/02A61K36/288A61K36/486A61K36/537A61K36/65A61K36/71A61K36/736A61K36/84A61K47/14A61P15/00A61K2300/00
Inventor 曾惠琼伍少霞张跃王绵生叶志中
Owner 深圳市福田区风湿病专科医院
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