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Application of anemonin in preparation of medicines for treating osteoarthritis

A technology of osteoarthritis and pulsatilla, which is applied in the field of medicine, can solve the problems that pulsatilla has no protective effect on osteoarthritis and other problems

Inactive Publication Date: 2015-02-11
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report that pulsacein has a protective effect on osteoarthritis

Method used

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  • Application of anemonin in preparation of medicines for treating osteoarthritis
  • Application of anemonin in preparation of medicines for treating osteoarthritis
  • Application of anemonin in preparation of medicines for treating osteoarthritis

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Embodiment Construction

[0017] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings. For the experimental methods that do not specify specific conditions in the examples, usually follow the conventional conditions or the conditions suggested by the manufacturer.

[0018] The pulsatillae (Anemonin) used in the embodiment of the present invention is purchased from ChromaDex Company of the United States, the chemical name is: 7-Dioxadispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione,trans, and the molecular formula is C 10 h 2 o 4 , the molecular weight is 192.16.

[0019] 1. Establishment of an unstable model of the medial meniscus

[0020] Destabilization of the medial meniscus (DMM) was performed by microsurgery to establish a mouse model of knee arthritis. The main steps of the operation are as follows: After the mouse was fixed and disinfected, the medial patellar ligament was incised with a microblade to expose the joint cavit...

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Abstract

The invention discloses application of anemonin in the preparation of medicines for treating osteoarthritis. After a mouse with the osteoarthritis is treated by virtue of anemonin, the degradation of joint cartilages and the hypertrophy of cartilages can be restrained, and the expression quantities of MMP13 and Collagen X are reduced. According to the application, the pharmaceutical use of anemonin is broadened, a new drug for treating the osteoarthritis by preventing the degradation cartilage matrixes and the abnormal hypertrophy of cartilage cells, and diseases can be treated based on the pathogenesis of the osteoarthritis in a targeted manner; the application has a very important significance on the clinic treatment of the osteoarthritis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of pulsacein in the preparation of medicine for treating osteoarthritis. Background technique [0002] At present, the treatment of osteoarthritis (Osteoarthritis, OA) mainly includes physical therapy, drug therapy and surgical treatment. Among them, surgical treatment (total joint replacement) is the only effective treatment for patients with advanced osteoarthritis, but the operation is expensive and has many complications. At this stage, the patient has experienced pain and dysfunction for a long time, and the quality of life is poor. severely affected. Therefore, screening drug targets for early intervention in osteoarthritis, and then developing corresponding treatment measures are important strategies to prevent and treat osteoarthritis and improve the quality of life of patients. At present, the drugs for the clinical treatment of osteoarthritis mainly...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P19/02A61P19/04
CPCA61K31/365A61K2300/00
Inventor 陈林王祖强谢杨丽黄俊兰罗凤涛周思儒徐伟孙先定
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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