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Application of bioactive polypeptide PACAP

A technology of biologically active peptides and derivatives, applied in the direction of medical preparations containing active ingredients, drug combinations, peptide/protein components, etc., can solve problems such as failure to achieve expected therapeutic effects, achieve pathological changes and cardiac function, inhibit Effects of cell cycle arrest and inhibition of apoptosis

Pending Publication Date: 2019-08-23
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
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Problems solved by technology

At present, the treatment of radiation heart injury usually follows the management standard of patients with conventional heart disease, and there is no specific target drug for radiation heart injury. Since the incubation period of radiation heart injury can be as long as 10-20 years, most of the time when symptoms are discovered There have been organic changes in the heart, the current drug intervention cannot achieve the expected therapeutic effect, and there is no mature drug for the prevention, treatment and repair of radiation-induced heart damage

Method used

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  • Application of bioactive polypeptide PACAP
  • Application of bioactive polypeptide PACAP
  • Application of bioactive polypeptide PACAP

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Select PACAP38 drugs for experimental verification:

[0021] Cells and animals: The H9C2 rat embryonic cardiomyocyte cell line (cell source: ATCC CRL-1446; cell characteristics: rat ventricular myoblasts, which can proliferate and subculture) was selected for cell experiment research, and C57 / BL6J mice were selected for cell experiment research. Animal Experimental Research.

[0022] Establish cell and animal irradiation models: the equipment for cell and animal irradiation is Varian Trilogy linear accelerator. Established and perfected a mature cell irradiation model: including fixation, positioning, irradiation plan design, irradiation implementation, continued cell culture and subsequent treatment after irradiation, and other related technical processes. The irradiation conditions of cells are: 6MV X-ray, dose rate 3Gy / min, SSD100cm, the machine arm is 180° upward, a 1cm plexiglass plate is placed under the culture dish as a compensation, and a 5cm plexiglass plate...

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Abstract

The invention relates to application of bioactive polypeptide PACAP in preparing drugs for preventing, treating or restoring cardiac trauma diseases. The bioactive polypeptide PACAP drugs can significantly prevent and relieve toxicity of radioactive cardiac traumas, the pathological change and heart function change of the radioactive cardiac traumas are repaired, and a novel sole targeted therapystrategy is provided for malignant chest tumor and radiotherapy patients with radioactive myocardial tissue traumas as features.

Description

technical field [0001] The invention belongs to the field of heart injury diseases, in particular to the application of a bioactive polypeptide PACAP. Background technique [0002] Radiation therapy is an important part of comprehensive tumor treatment, and about 52.3% of tumor patients need radiation therapy during their anti-tumor treatment. With the increase in the number of patients receiving radiation therapy and the improvement of overall survival of patients, more and more attention has been paid to radiation-related adverse reactions, among which radiation-related heart diseases (RRHDs) have become a non-tumor disease in patients undergoing radiation therapy for thoracic malignancies. One of the leading causes of death. All structures of the heart, including the pericardium, myocardium, heart valves, conduction system, and coronary arteries are potentially subject to radiation injury. The types of radiation-related heart diseases mainly include coronary atheroscler...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K45/00A61P9/00
CPCA61K38/1709A61K45/00A61P9/00
Inventor 李敏李欢易培强曹璐陈佳艺
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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