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Traditional Chinese medicine composition for hyperplasia of mammary glands and preparation method of hydrogel patch thereof

A hydrogel patch and mammary gland hyperplasia technology, which is applied in the field of medicine, can solve the problems of inconvenient administration, easy relapse, and short duration of action of mammary gland hyperplasia, and achieve long drug action time, significant therapeutic effect, and skin-free stimulating effect

Inactive Publication Date: 2011-05-11
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a Chinese medicine composition for mammary gland hyperplasia, which solves the liver first-pass effect, short duration of drug action, and poor breast targeting of existing mammary gland hyperplasia in the clinical treatment process of oral medicine, especially western medicine. , The problem of inaccurate treatment effect and easy recurrence of mammary gland hyperplasia caused by large toxic side effects and inconvenient administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Step 1: Take 350g Scrophulariaceae, 350g orange core, 250g litchi core, 250g Liu Jinu, 300g Shanzi mushroom, 400g acacia, 250g Corydalis 250g, 250g seaweed, 100g clove, 300g impatient, coarsely crush, add 95% of 10 times the mass % ethanol reflux extraction for 1 hour; add 10 times the mass of 70% ethanol reflux extraction twice, each time for 1 hour, combine and concentrate the three extracts to obtain the drug extract;

[0043] Step 2: Add 400g of partially neutralized sodium polyacrylate skeleton material, 300g of ceramic powder, 30g of aluminum glycinate, and 8g of disodium edetate to 4650g of glycerin, and stir for 15 minutes under a vacuum of -0.08MPa to obtain Glycerin phase;

[0044] Step 3: Dissolve 35g of tartaric acid and 650g of polyvinylpyrrolidone in 4000g of distilled water, and dissolve 32g of an equal proportion mixture of ethylparaben, propylparaben and methylparaben in 250mL of absolute ethanol to obtain an acidic aqueous phase and an ethanol phase, r...

Embodiment 2

[0049] Step 1: Take 400g Scrophulariaceae, 250g orange core, 200g litchi core, 350g Liu Jinu, 400g Shanzi mushroom, 450g acacia, 300g Corydalis 300g, 350g seaweed, 150g clove, 450g impatient, coarsely crush, add 95% of 10 times the mass % ethanol reflux extraction for 1 hour; add 10 times the mass of 70% ethanol reflux extraction twice, each time for 1 hour, combine and concentrate the three extracts to obtain the drug extract;

[0050] Step 2: Add 500 g of partially neutralized sodium polyacrylate skeleton material, 300 g of ceramic powder, 35 g of aluminum glycinate, and 10 g of disodium edetate into 4800 g of glycerin, and stir for 15 minutes under a vacuum of -0.08 MPa to obtain Glycerin phase;

[0051] Step 3: Dissolve 43g of tartaric acid and 700g of polyvinylpyrrolidone in 5000g of distilled water, and dissolve 32g of an equal proportion mixture of ethylparaben, propylparaben and methylparaben in 250mL of absolute ethanol to obtain an acidic aqueous phase and an ethanol...

Embodiment 3

[0056] Step 1: Take 250g Scrophulariaceae, 300g orange core, 300g litchi core, 450g Liu Jinu, 500g Shanzi mushroom, 300g acacia, 450g Corydalis 450g, 300g seaweed, 80g clove, and 500g acute seed, coarsely crush them, add 95 % ethanol reflux extraction for 1 hour; add 10 times the mass of 70% ethanol reflux extraction twice, each time for 1 hour, combine and concentrate the three extracts to obtain the drug extract;

[0057] Step 2: Add 350g of sodium polyacrylate skeleton material, 550g of polyvinylpyrrolidone, 300g of a mixture of ceramic powder, kaolin and kaolin, 26g of aluminum hydroxide, and 6g of disodium ethylenediaminetetraacetic acid into 4700g of propylene glycol. Under 0.08MPa, stir for 15 minutes to obtain the glycerol phase;

[0058] Step 3: Dissolve 30 g of citric acid in 3800 g of distilled water, and dissolve 32 g of an equal proportion mixture of ethyl paraben, propyl paraben and methyl paraben in 250 mL of absolute ethanol to obtain an acidic aqueous phase an...

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Abstract

The invention discloses a traditional Chinese medicine composition for hyperplasia of mammary glands and a preparation method of a hydrogel patch thereof. The traditional Chinese medicine composition comprises figwort root, tangerine seed, lychee seed, diverse wormwood herb, Indian iphigenia bulb, honeylocust, rhizoma corydalis, seaweed, flos caryophyllata and garden balsam, and a pharmaceutical extract of the traditional Chinese medicine composition is obtained by extraction. The preparation method of the hydrogel patch of the traditional Chinese medicine composition for the hyperplasia of the mammary glands comprises the following steps: using a framework material, a tackifier, a humectant, a preservative, a filler, a crosslinking agent, a crosslinking regulator, a pH regulator, the pharmaceutical extract and distilled water to prepare a medicine-loaded hydrogen patch matrix; and then performing coating, cutting, standing and other steps, thus obtaining the hydrogel patch. The traditional Chinese medicine composition has a target treatment role of directly delivering the pharmaceutical active ingredients to tissues with hyperplasia lesion of the mammary glands, has the long-acting sustained-release role for sustained release of the pharmaceutical active ingredients for a long time, is convenient and comfortable to use and has the advantages of no skin irritation, no allergy and the like, thereby being an ideal pharmaceutical preparation for treating the hyperplasia of the mammary glands.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for mammary gland hyperplasia, and also relates to a preparation method of a hydrogel patch of the traditional Chinese medicine composition. Background technique [0002] Mammary gland hyperplasia is the most common breast disease in women, and its incidence accounts for about 40% of women of childbearing age, and the incidence is increasing year by year and the age of onset is getting younger. Clinically, breast pain and lumps in different degrees are the main manifestations, and it is easy to recur. Typical breast hyperplasia is closely related to breast cancer and has a certain tendency to become cancerous. It is the focus of primary prevention of breast cancer. Therefore, patients often have a heavy psychological burden, and their life and work are seriously affected. Modern medicine believes that the nervous and mental...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/70A61K47/32A61P15/14
Inventor 李伟泽闫菁华周永强韩文霞
Owner XIAN MEDICAL UNIV
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