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Medicinal composition used for treating or preventing cerebrovascular disease and related diseases

A composition and cerebrovascular technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, peptide/protein ingredients, etc., and can solve the problems of unsuitable long-term use, long action time, and slow onset of traditional Chinese medicine.

Active Publication Date: 2014-11-12
GUIZHOU MAQIKA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, Western medicine has the characteristics of fast healing speed and obvious symptomatic treatment effect, but it is not suitable for long-term use, and the type of medicine needs to be replaced after a period of time; while Chinese medicine compound contains multiple medicines, and single medicine contains multiple ingredients, so Chinese medicine can be passed through multi-level. , multi-target, and multi-link play a role, but the onset of Chinese medicine is slow and the action time is long; therefore, with the progress of science and the deepening of research, more and more researches have been done on the combination of Chinese and Western medicine. This is due to the combination of Chinese and Western medicine. It can achieve good effects such as synergizing and synergizing, reducing toxic and side effects, reducing dosage, and reducing contraindications

Method used

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  • Medicinal composition used for treating or preventing cerebrovascular disease and related diseases
  • Medicinal composition used for treating or preventing cerebrovascular disease and related diseases
  • Medicinal composition used for treating or preventing cerebrovascular disease and related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Prescription: DHA10mg, breviscapine 15mg, ligustrazine phosphate 25mg, hirudin 3mg;

[0081] Preparation process: (1) Take the prescribed amount of DHA, breviscapine, ligustrazine phosphate and hirudin, dissolve them in 5.3ml of phosphate buffer, and prepare a mixed solution with a concentration of 10mg / ml;

[0082] (2) Take the collected adipose tissue, remove the blood vessels and fibers visible to the naked eye, cut it into pieces, wash it several times with D-Hanks balanced salt solution with a pH value of 7.2-7.4, remove the residual blood, and add the same volume as the adipose tissue 0.3% (m / v) mixed collagenase, and evenly shaken and digested for 60 minutes, then centrifuged in a centrifuge for 5 minutes to remove the surface fat, and the bottom cells were repeatedly washed with D-Hanks balanced salt solution with a pH value of 7.2-7.4 Wash, filter through a 100-mesh sieve, centrifuge the filtrate for 8 minutes, discard the supernatant, and divide the obtained s...

Embodiment 2

[0085] Prescription: DHA40mg, breviscapine 40mg, ligustrazine phosphate 45mg, hirudin 8mg;

[0086] Preparation process: (1) Take the prescribed amount of DHA, breviscapine, ligustrazine phosphate and hirudin, dissolve them in 8.9ml of phosphate buffer, and prepare a mixed solution with a concentration of 15mg / ml;

[0087](2) Take the collected adipose tissue, remove the blood vessels and fibers visible to the naked eye, cut it into pieces, wash it several times with D-Hanks balanced salt solution with a pH value of 7.2-7.4, remove the residual blood, and add the same volume as the adipose tissue 0.2% (m / v) mixed with collagenase, evenly shaken and digested for 80 minutes, then placed in a centrifuge for 10 minutes to remove the surface fat, and the bottom cells were repeatedly washed with D-Hanks balanced salt solution with a pH value of 7.2-7.4 Wash, filter through a 100-mesh sieve, centrifuge the filtrate for 5 minutes, discard the supernatant, and divide the obtained stem ...

Embodiment 3

[0090] Prescription: DHA1mg, breviscapine 1mg, ligustrazine phosphate 20mg, hirudin 1mg;

[0091] Preparation process: (1) Take the prescribed amount of DHA, breviscapine, ligustrazine phosphate and hirudin, dissolve in 4.0ml phosphate buffer, and prepare a mixed solution with a concentration of 5mg / ml;

[0092] (2) Take the collected adipose tissue, remove the blood vessels and fibers visible to the naked eye, cut it into pieces, wash it several times with D-Hanks balanced salt solution with a pH value of 7.2-7.4, remove the residual blood, and add the same volume as the adipose tissue 0.4% (m / v) mixed with collagenase, evenly shaken and digested for 40 minutes, then placed in a centrifuge for 4 minutes to remove the surface fat, and the bottom cells were repeatedly washed with D-Hanks balanced salt solution with a pH value of 7.2-7.4 Wash, filter through a 100-mesh sieve, centrifuge the filtrate for 10 minutes, discard the supernatant, and divide the obtained stem cells into...

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Abstract

The invention discloses a medicinal composition used for treating or preventing cerebrovascular disease and related diseases. The composition comprises the following components in parts by weight: 1-50 parts of DHA (docosahexaenoic acid), 1-50 parts ofbreviscapine, 20-50 parts of and 1-10 parts of hirudin. The composition also comprises effective amount of human fat stem cell which is taken as a carrier for the medicinal composition, thus treatment medicine smoothly penetrates through a blood brain barrier, and the effect of targeted treatment on the cerebrovascular disease and related diseases is achieved. The medicinal composition disclosed by the invention can effectively improve diseases such as attack, infarction and embolism which are caused by ischemia of the brain, can effectively inhibit thrombus from being formed in human body and has good curative effect on senile dementia caused by the cerebrovascular disease, namely presenile dementia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cerebrovascular and related diseases, in particular to a pharmaceutical composition for treating cerebrovascular and related diseases by using human adipose stem cells as drug carriers. technical background [0002] Cerebrovascular diseases are common and frequently-occurring diseases that endanger human life and health. Leading diseases that kill and disable middle-aged adults. Due to the continuous increase of the elderly population and the improvement of living standards, the incidence of cerebrovascular disease is still rising. Among the causes of death of various human diseases, cerebrovascular disease has always been listed in the top three, becoming one of the main causes of human death. Globally, it kills 4.6 million people each year, mostly in people over the age of 65. my country is also an area with a high incidence of stroke mortality. It is estimated that 6 million resid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/58
Inventor 张芝庭
Owner GUIZHOU MAQIKA PHARMA
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