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Passive automatic antifoam delivery system for use with single-use bioreactors

A technology of bioreactor and defoamer, which is applied in specific-purpose bioreactor/fermenter, bioreactor/fermenter combination, biochemical instrument, etc., can solve problems such as system controller failure

Pending Publication Date: 2018-04-17
GLOBAL LIFE SCI SOLUTIONS USA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Errors in the system controller response to foam can also be attributed to problems with a particular situation of the system controller, i.e., that particular system controller is faulty

Method used

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  • Passive automatic antifoam delivery system for use with single-use bioreactors
  • Passive automatic antifoam delivery system for use with single-use bioreactors
  • Passive automatic antifoam delivery system for use with single-use bioreactors

Examples

Experimental program
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Embodiment Construction

[0041] The present disclosure is generally directed to using antifoaming agent devices and methods in order to improve the use of bioreactor bags. As will be appreciated, the various diagrams, flowcharts, and scenarios described herein are examples only, and that there are many other scenarios to which the present disclosure will apply.

[0042] see figure 1 , figure 2 and Figure 7 , showing two embodiments of passive defoamer systems. In these figures, the exhaust gas outflow pipe 1 is shown connected to a section of the bioreactor bag wall 4 via a port fitting 6 a which can be heat welded to the bag membrane 4 . The tube can be made from one of many materials commonly used in the pharmaceutical industry such as platinum cured silicon or C-Flex. Tubes may be flexible, semi-rigid or rigid. There may be one or more exhaust gas outflow tubes attached to the bioreactor bag 11 . The other end of each exhaust pipe may be connected to a condenser (not shown), an exhaust filt...

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Abstract

The aspects of the disclosed embodiments generally relate to an apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments also generally relate toa method of using such apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments generally relate to antifoam systems, methods and apparatus, and more particularly, toan antifoam device operably connected to a single use biobag.

Description

technical field [0001] Aspects of the disclosed embodiments generally relate to an apparatus that allows the controlled addition of an antifoam agent to foam present in the headspace of a disposable, single-use bioreactor in a reliable manner. Aspects of the disclosed embodiments also generally relate to methods of using such devices that allow controlled addition of antifoam agents to foam present in the headspace of disposable, single-use bioreactors in a reliable manner. Aspects of the disclosed embodiments relate generally to antifoam systems, methods, and apparatus, and more specifically, to antifoam devices operably connected to single-use biobags. Background technique [0002] A bioreactor is a device or device in the form of a closed chamber or vessel in which a living organism such as mammalian cells, bacteria, or yeast synthesizes substances useful in the pharmaceutical and biotechnology industries under controlled conditions favorable to that particular organism ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/21
CPCC12M23/14C12M23/28C12M41/02
Inventor R.L.达姆伦
Owner GLOBAL LIFE SCI SOLUTIONS USA LLC
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