Hydrophobic drug entrapped lipid-polymer with dual functions of targeting and radiosensitivity as well as preparation method and application of lipid-polymer

Abstract

The invention discloses a hydrophobic drug entrapped lipid-polymer with dual functions of targeting and radiosensitivity. The lipid-polymer comprises lipid molecules with a targeting function, a poly-nitroimidazole organic polymer with radiosensitivity and a hydrophobic anti-cancer drug, wherein the lipid molecules (DSPE-PEG-target) with the targeting function, soybean lecithin and DSPE-PEG are prepared from polypeptide and targeting molecules with the targeting function in the lipid molecules through chemical reactions, the hydrophobic poly-nitroimidazole organic polymer is prepared from functional groups, namely nitroimidazole, with the radiosensitivity under the action of polymerization, and the polymer is prepared from the targeting lipid molecules, the soybean lecithin, the poly-nitroimidazole organic polymer and the hydrophobic anti-cancer drug through hydrophilic/hydrophobic compounding. The radiosensitivity is improved, the synergetic treatment effects of radiotherapy and chemotherapy upon tumor are improved, and a toxic and side effect reduction function is achieved; and a synchronous treatment function of radiotherapy sensitizers and anti-cancer medicine molecules is achieved, and clinical practicability and practical treatment significances can be achieved.

Description

technical field [0001] The invention relates to a lipid-polymer with dual functions of targeting and radiotherapy sensitization loaded with hydrophobic anticancer drugs, its preparation method and application, belonging to the field of tumor drug preparation. Background technique [0002] The treatment of tumors is still based on surgery, radiotherapy and chemotherapy. The synergistic treatment of tumors with radiotherapy and chemotherapy has become the main means of tumor treatment. In recent years, many studies have confirmed that the curative effect of simultaneous radiotherapy and chemotherapy is better than that of radiotherapy and chemotherapy separately. toxic side effects. [0003] In recent years, the number of patients treated with tumor radiotherapy has been increasing day by day. Due to the existence of hypoxia in solid tumors, it is still difficult to cure the tumors even if the maximum possible radiation dose or the radiation method is changed. In order to ef...

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Problems solved by technology

(2) Combination of radiotherapy and chemotherapy: Clinically, synchronous radiotherapy and chemotherapy are used to treat tumors a

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