Information transformation in digital pathology
A digital and physical technology, applied in the field of annotation conversion, which can solve problems such as artificial traces
Active Publication Date: 2018-05-11
KONINKLJIJKE PHILIPS NV
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Therefore, when processing sample slides, there are artifacts of annotation
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[0066] Unless otherwise specified, the same or similar reference numerals appearing in different drawings designate the same or similar components.
[0067] The present invention relates to the illumination of annotations at sample slides. Annotated illumination can improve the efficiency and / or quality of workflows, which enable analysis in the field of digital pathology, especially with molecular diagnostics. The respective analysis can be difficult and may require a detailed analysis of the fine structure of the biological material, especially the cells and / or their topography. Therefore, classifying tissue into normal and tumor types can be difficult. Illumination of annotations at the sample slide can speed up the workflow.
[0068] An example of an object 10 is shown.
[0069] Object 10 contains biological material. In an example, the object 10 relates to a sample of biological material, in particular forming a block of biological material.
[0070] Accordingly, the...
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The present invention relates to an illustration of an annotation (22) at a sample slide (14). It is the intention for the invention to copy the annotation (22) provided at a reference slide (12) to the sample slide (14). Typically, a reference image (26) of the reference slide (12) is provided, in particular by scanning the reference slide (12). The reference image (26) therefore has the information about a reference slice (16) which is carried by the reference slide (12). Furthermore, the reference slide (12) has been marked with a region of interest (20) and the annotation (22), which can be associated with the region of interest (20). If the reference slide (12) is scanned, the respective reference image (26) comprises the information about the marked region of interest (20) as well asthe annotation (22), too. Furthermore, the sample slide (14) carrying a sample slice (18) can be scanned, in order to provide a sample image (28). The sample slice (18) and the reference slice (16) are cut from the same object (10) of a biological material. In particular, the sample slice (16) has been cut directly after a cut of a material block has been preformed to provide the reference slice(18). Since the reference slice (16) and the sample slice (18) are from the same object (10), their features are very likely that the reference image (26) and the sample image (28) are very similar. Due to this similarity, the annotation (22) of the reference slide (12) is copied on a basis of image recognition between reference image (26) and the sample image (28) to the sample slide (14).
Description
technical field [0001] The present invention relates to digital pathology, and in particular to the conversion of annotations between slides bearing slices of biological material. Background technique [0002] Pathologists have a central role in the diagnostic portion of the treatment cycle. When a sample of biological material is taken from a patient during a biopsy, it is usually the pathologist who makes the final diagnosis as to the nature and severity of the underlying disease through microscopic examination of the tissue and cells from the biopsy. [0003] In one example, a glass slide for microscopic examination can be prepared in several steps as described below. First, samples of biological material can be mounted in formalin for fixation and subsequently processed into paraffin blocks from which thin sections of approximately 5 μm are cut. One of these sections is then mounted on a slide substrate, in particular a glass substrate, after which one or more staining...
Claims
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IPC IPC(8): G06T7/00G06T11/00G06T7/30
CPCG06T7/0012G06T11/00G06T2200/24G06T2207/30024G06T7/30G06T7/11G06T7/33G06T7/337G06T19/00G06T2207/20104G06T2207/30096G06T2207/30204G06T2219/004
Inventor J.P.温克R.维鲁特斯A.皮伊里克B.胡斯肯R.维姆伯格-弗里伊德S.尼肯
Owner KONINKLJIJKE PHILIPS NV