Compound sodium acetate Ringer's injection and preparation method thereof

A technology of Ringer injection and compound sodium acetate, which is applied in the field of injection, can solve the problems of unfavorable nutrient supplementation for patients, false judgment of condition of critically ill patients, unreasonable formula of supplemental infusion, etc., to ensure biological safety and avoid serum lactic acid The effect of increased content and drug safety

Inactive Publication Date: 2018-05-25
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a compound sodium acetate Ringer's injection and a preparation method thereof, which solves the problems in the prior art that the formulation of the supplementary infusion is unreasonable, which is not conducive to the supplementation of nutrients by patients, and at the same time causes false impressions to the condition judgment of critically ill patients.

Method used

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  • Compound sodium acetate Ringer's injection and preparation method thereof
  • Compound sodium acetate Ringer's injection and preparation method thereof
  • Compound sodium acetate Ringer's injection and preparation method thereof

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preparation example Construction

[0023] The preparation method of a compound sodium acetate Ringer injection of the present invention comprises the following steps: 1) Adding 50-70% of the prescription amount of injection water into the concentrated preparation tank, the temperature of the injection water is 60-70°C, and then adding Stir the prescription amount of magnesium chloride hexahydrate, calcium gluconate monohydrate and anhydrous glucose until dissolved to obtain the initial solution; 2) adjust the pH of the initial solution obtained in step 1) to make the pH value 4.7-5.5, then add the prescription amount of potassium dihydrogen phosphate, after it is completely dissolved, add the prescribed amount of sodium chloride, potassium chloride and sodium acetate trihydrate in sequence, stir and dissolve to obtain a concentrated solution; 3) to the concentrated solution obtained in step 2), add Activated carbon whose weight is 0.1-0.2% of the volume of the concentrated solution is stirred, heat-preserved and...

Embodiment 1

[0030] A kind of preparation method of compound sodium acetate Ringer's injection of the present invention comprises the following steps:

[0031] 1) Weigh the following raw materials: 0.800g sodium chloride, 0.700g potassium chloride, 0.280g magnesium chloride hexahydrate, 1.000g calcium gluconate monohydrate, 1.300g potassium dihydrogen phosphate, 1.500g sodium acetate trihydrate, anhydrous glucose 90g, appropriate amount of water for injection;

[0032] 2) Add 50% of the prescribed amount of injection water into the concentrated preparation tank, and the temperature of the injection water is 60°C. Then, add the above-mentioned prescribed amount of magnesium chloride hexahydrate, calcium gluconate monohydrate and anhydrous glucose, and stir until dissolved to obtain initial solution;

[0033] 3) Adjust the pH of the above initial solution to make the pH value 4.7, then add the above prescription amount of potassium dihydrogen phosphate, after it is completely dissolved, add...

Embodiment 2

[0037] A kind of preparation method of compound sodium acetate Ringer's injection of the present invention comprises the following steps:

[0038] 1) Weigh the following raw materials: 0.900g sodium chloride, 0.800g potassium chloride, 0.350g magnesium chloride hexahydrate, 1.200g calcium gluconate monohydrate, 1.400g potassium dihydrogen phosphate, 1.700g sodium acetate trihydrate, anhydrous glucose 110g, appropriate amount of water for injection;

[0039] 2) Add 70% of the prescribed amount of water for injection into the concentrated preparation tank. The temperature of the injected water is 65°C. Then, add the above-mentioned prescribed amount of magnesium chloride hexahydrate, calcium gluconate monohydrate and anhydrous glucose, and stir until dissolved to obtain initial solution;

[0040] 3) Adjust the pH of the above initial solution to make the pH value 5.5, then add the above prescription amount of potassium dihydrogen phosphate, after it is completely dissolved, add...

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Abstract

The invention discloses a compound sodium acetate Ringer's injection and a preparation method thereof and belongs to the technical field of injections. 1L of the injection is prepared from raw materials in parts by weight as follows: 0.800-0.900 g of sodium chloride, 0.700-0.800 g of potassium chloride, 0.280-0.350 g of magnesium chloride hexahydrate, 1.000-1.200 g of calcium gluconate monohydrate, 1.300-1.400 g of monopotassium phosphate, 1.500-1.700 g of sodium acetate trihydrate and 90-110 g of anhydrous dextrose. The invention further provides the preparation method of the injection. The injection is a hypotonic electrolyte glucose injection, belongs to an intracellular fluid replenisher, supplements moisture and electrolytes to intracellular fluid, extracellular fluid and intercellular fluid simultaneously after entering a human body, and is mainly used for maintaining balance of moisture and electrolytes and supplying energy to the organism when oral intake cannot be performed orenergy intake is insufficient.

Description

technical field [0001] The invention belongs to the technical field of injections, in particular to a compound sodium acetate Ringer injection and a preparation method thereof. Background technique [0002] Perioperative glucose and electrolyte infusions are often divided into maintenance infusions and supplementary infusions according to their different purposes. Complementary infusion is relative to the maintenance infusion that meets the physiological needs, including the continued treatment of body fluid loss caused by surgical diseases and intraoperative body fluid loss. Additional losses due to decompression, intestinal fistula, etc. Water deficiency can be calculated from weight loss or the difference between essential water and water intake; electrolyte deficiency can be estimated based on daily excretion or plasma electrolyte concentration. Maintenance infusions and supplemental infusions contain different concentrations of electrolytes. Maintenance infusions are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K9/08A61P3/12A61K33/14A61K33/06A61K31/7004A61K31/191A61K31/19
CPCA61K33/42A61K9/0019A61K9/08A61K31/19A61K31/191A61K31/7004A61K33/06A61K33/14A61K2300/00
Inventor 王文玲陆宇
Owner HUAREN PHARMACEUTICAL CO LTD
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