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Antibacterial compound sodium acetate Ringer's injection and preparation method thereof

A technology of Ringer injection and compound sodium acetate, which is applied in the direction of antibacterial drugs, pharmaceutical formulas, active ingredients of anhydrides/acids/halides, etc., can solve the problems of low sterility assurance level, inconvenient use, and high production cost. Achieve the effect of preventing postoperative infection and saving production cost

Inactive Publication Date: 2018-09-21
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for postoperative use, only supplementary infusion can be performed. If it is necessary to avoid postoperative infection, additional injection of antibacterial drugs is required
However, most of the existing antibacterial drugs are in the form of freeze-dried preparations. Since the freeze-dried preparations cannot be sterilized by autoclaving, compared with injections, the sterility assurance level is low, and the production cost is high. inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The composition ratio of antibacterial compound sodium acetate Ringer injection of the present invention, every 1000mL injection is made up of following components: Yanhuning 1.2g, cefotaxime sodium 10.3g, metronidazole 2.5g, sodium acetate 3.5g, chlorine Sodium chloride 4.5g, potassium chloride 0.12g, magnesium chloride 0.19g, potassium dihydrogen phosphate 0.21g, calcium gluconate monohydrate 1.0g, anhydrous glucose 30g, citric acid 0.56g, and the balance is water for injection.

[0029] The preparation method is as follows:

[0030] (1) Add sodium chloride, potassium chloride, magnesium chloride, potassium dihydrogen phosphate, calcium gluconate monohydrate, and anhydrous glucose into the concentrated preparation tank, add 30% water for injection, heat and stir to dissolve, and add 0.8-2g of Wet activated carbon for needles, boil and stir for 25-35 minutes, reflux the medicinal solution through a titanium rod for 10-20 minutes, and filter through a 1.0 μm filter elem...

Embodiment 2

[0037] The composition ratio of antibacterial compound sodium acetate Ringer injection of the present invention, every 1000mL injection is made up of following components: Yanhuning 1.4g, cefotaxime sodium 12.5g, metronidazole 3.7g, sodium acetate 3.8g, chlorine Sodium chloride 5.7g, potassium chloride 0.15g, magnesium chloride 0.21g, potassium dihydrogen phosphate 0.31g, calcium gluconate monohydrate 1.2g, anhydrous glucose 40g, citric acid 0.59g, and the balance is water for injection.

[0038] The preparation method is the same as in Example 1.

Embodiment 3

[0040] The composition ratio of antibacterial compound sodium acetate Ringer injection of the present invention, every 1000mL injection is made up of following components: Yanhuning 1.3g, cefotaxime sodium 7.6, metronidazole 2.8g, sodium acetate 3.5-3.8g, Sodium chloride 4.9g, potassium chloride 0.13g, magnesium chloride 0.19g, potassium dihydrogen phosphate 0.27g, calcium gluconate monohydrate 1.1g, anhydrous glucose 36g, citric acid 0.57g, and the balance is water for injection.

[0041] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses an antibacterial compound sodium acetate Ringer's injection and a preparation method thereof. Each 1000 mL of the injection comprises 1.2-1.4 g of potassium sodium dehydroandrographolide succinate, 10.3-12.5 g of cefotaxime sodium, 2.5-3.7 g of metronidazole, 3.5-3.8 g of sodium acetate, 4.5-5.7 g of sodium chloride, 0.12-0.15 g of potassium chloride, 0.19 -0.21 g of magnesium chloride, 0.21-0.31 g of potassium dihydrogen phosphate, 1.0-1.2 g of calcium gluconate monohydrate, 30-40 g of anhydrous glucose and 0.56-0.59 g of citric acid, with the balance being water for injection. According to the invention, sodium acetate Ringer's liquid is used as carrier liquid and antibacterial drugs are added, so the antibacterial compound sodium acetate Ringer's injection has significant effect on the defense and treatment of postoperative infections while realizing supplementary infusion.

Description

technical field [0001] The invention relates to a compound sodium acetate Ringer injection with antibacterial effect. Background technique [0002] Perioperative glucose and electrolyte infusions are often divided into maintenance infusions and supplementary infusions according to their different purposes. Complementary infusion is relative to the maintenance infusion that meets the physiological needs, including the continued treatment of body fluid loss caused by surgical diseases and intraoperative body fluid loss. Additional losses due to decompression, intestinal fistula, etc. Water deficiency can be calculated from weight loss or the difference between essential water and water intake; electrolyte deficiency can be estimated based on daily excretion or plasma electrolyte concentration. Maintenance infusions and supplemental infusions contain different concentrations of electrolytes. Maintenance infusions are given in daily amounts, including nutrients such as water,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K33/42A61K9/08A61P31/04A61P3/12A61P3/14A61K33/14A61K31/194A61K31/365A61K31/4164A61K31/7004A61K33/06A61K31/19
Inventor 蔡萧芳陈磊
Owner NANJING CHIA TAI TIANQING PHARMA
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