Traditional Chinese medicinal composition for treating chronic obstructive pulmonary diseases

A chronic obstructive, composition technology, used in drug combinations, pharmaceutical formulations, respiratory diseases, etc.

Active Publication Date: 2018-06-01
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ginkgo biloba extract is one of the most widely used traditional Chinese medicine extracts in the world at present. Ginkgolide is the main active ingredient of Ginkgo biloba extract and its preparations. So far, there is no evidence that Ginkgo biloba extract can treat chronic obstructive pulmonary disease. Relevant reports of pulmonary diseases with therapeutic or preventive effects

Method used

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  • Traditional Chinese medicinal composition for treating chronic obstructive pulmonary diseases
  • Traditional Chinese medicinal composition for treating chronic obstructive pulmonary diseases
  • Traditional Chinese medicinal composition for treating chronic obstructive pulmonary diseases

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Embodiment Construction

[0012] Hereinafter, the present invention will be described in more detail through specific embodiments, so as to better understand the solutions of the present invention and the advantages of various aspects thereof. However, the content of the specific embodiments described below is only for the purpose of illustration, rather than limiting the present invention.

[0013] It should be noted that if the specific conditions are not specified, they are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The raw materials or excipients used, as well as the reagents or instruments used without indicating the manufacturer, can be obtained from the market. conventional products. All percentages, ratios, proportions or parts are by weight unless otherwise indicated.

[0014] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. In addit...

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Abstract

The invention provides applications of a bilobalide composition in preparing medicines for preventing/treating chronic obstructive pulmonary diseases. The experiment proves that the bilobalide composition has the efficacies of improving the respiratory rate and pulmonary function of a model rat, reducing the expression of IFN-gamma and IL-6 of a model group rat, increasing the expression of IL-10of the model rat, increasing the number of pulmonary alveoli, reducing the content of collagen, and alleviating the airway remodeling in a dose-dependent manner, so that the effect of treating the chronic obstructive pulmonary diseases is achieved. Therefore, the bilobalide composition has the effect and application value of being prepared into medicines for preventing/treating the chronic obstructive pulmonary diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of a ginkgolide composition in the treatment / prevention of chronic obstructive pulmonary disease. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by airflow limitation that is not fully reversible, and the airflow limitation is progressive and aggravated, which is related to the inflammatory response of the lungs. The pathological changes of COPD exist in the central airway, peripheral airway, lung parenchyma and pulmonary vasculature. In the central airways, inflammatory cells infiltrate the epidermis, enlarging the mucus-secreting glands, and increasing the number of goblet cells, leading to increased mucus secretion. Within the peripheral airways, chronic inflammation leads to a cyclical process of injury and repair of the airway walls. Repeated repairs lead to remodeling of the airway wall struct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P11/00
CPCA61K31/365
Inventor 萧伟王俨如吴秀胡晗绯许治良周军周建明王振中
Owner JIANGSU KANION PHARMA CO LTD
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