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Preparation method of gold nano-loaded resveratrol

A technology of resveratrol and gold nanometers, which is applied in the fields of nanomaterials and pharmacy, can solve the problems of great harm to the human body, and achieve the effect of simple preparation method and mild reaction conditions

Inactive Publication Date: 2019-12-17
SOUTHWEST UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional drug chemotherapy is extremely harmful to the human body, and the rise of nanomaterials has brought new opportunities for the development of anticancer drugs

Method used

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  • Preparation method of gold nano-loaded resveratrol
  • Preparation method of gold nano-loaded resveratrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Preparation of Res-GNPs and appearance analysis

[0019] Form a suspension with 0.001 g of resveratrol and 5 ml of first-grade water, then add 97.1 ul of chloroauric acid solution with a concentration of 50 mmol / L into the suspension, and react at 25 °C for 2 h to obtain A solution of gold nanoparticles loaded with resveratrol (Res-GNPs).

[0020] Such as figure 1 As shown, when the color of the solution changed from bright yellow to wine red, it indicated the successful preparation of Res-GNPs from the appearance.

Embodiment 2

[0021] Example 2 Preparation of Res-GNPs and Appearance Analysis

[0022] Form a suspension of 0.001g of resveratrol and 5ml of first-grade water, then add 97.1ul of chloroauric acid solution with a concentration of 50mmol / L into the suspension, and react at 37°C for 40min to obtain gold Solutions of nanoloaded resveratrol (Res-GNPs). The color of the solution changed from yellow to clear wine red, indicating the successful preparation of Res-GNPs from the appearance.

[0023] Obtain wine red solution by the preparation method of embodiment 1, this solution is measured with transmission electron microscope (TEM), Zate potential and ultraviolet spectrum respectively, as figure 2 Shown:

[0024] Such as figure 2 A, TEM results show that the prepared Res-GNPs are uniform in size and round in shape;

[0025] Such as figure 2 B, Zate potential results show that the yield of Res-GNPs prepared from resveratrol can reach 72%, and the size is 39 nm;

[0026] Such as figure 2...

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Abstract

The invention discloses a preparation method of gold nano-loaded resveratrol. The gold nano-loaded resveratrol is obtained by performing a reaction on a natural resveratrol product and a chloroauric acid solution, and is characterized by different means. The preparation method is simple, the reaction condition is mild, and high temperature and high pressure are not needed.

Description

technical field [0001] The invention relates to the fields of nanomaterials and pharmacy, in particular to a preparation method for carrying resveratrol in chloroauric acid solution. Background technique [0002] Resveratrol (Res) is a polyphenolic white powder compound with a chemical name of 3,4',5-trihydroxystilbene. After 1970, people gradually discovered grapes, peanuts, and mulberries around us. Resveratrol is found in wine for the first time in 1992. According to research, it has various biological activities such as antibacterial effect, anti-oxidation, anti-free radical effect, anti-aging, prevention of heart and liver damage, and enhancement of immune system activity. Breast cancer, liver cancer, pancreatic cancer, etc. However, due to the poor water solubility and stability of resveratrol, its application in the field of anti-tumor is greatly limited. [0003] Liver cancer is one of the most common malignant tumors in the world, ranking fifth among male maligna...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K31/05A61P35/00
CPCA61K31/05A61K47/02
Inventor 赵晓燕黄承志张朵朵张杰
Owner SOUTHWEST UNIV