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Silica-based biomolecule carrier, pharmaceutical composition comprising the same, preparation method and use thereof

A technology of biomolecules and silicon oxide, which is used in the fields of medical preparations, pharmaceutical formulations, and biological material analysis that are not active ingredients.

Inactive Publication Date: 2018-08-03
牟中原
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the limitations of some existing practices, especially regarding issues such as cell uptake, calibration and delivery, it is necessary to explore more satisfactory solutions

Method used

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  • Silica-based biomolecule carrier, pharmaceutical composition comprising the same, preparation method and use thereof
  • Silica-based biomolecule carrier, pharmaceutical composition comprising the same, preparation method and use thereof
  • Silica-based biomolecule carrier, pharmaceutical composition comprising the same, preparation method and use thereof

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Embodiment Construction

[0017] Reference is now made in detail to the preferred embodiments of the invention, examples of which are illustrated in the accompanying drawings. In the following specific examples, one or more silica-based biomolecule carriers are illustrated. The examples, components, reaction conditions or parameters described in the examples are for illustrative purposes only, and are not intended to limit the materials or preparation methods by the illustrative examples described herein.

[0018] In certain embodiments, at least two different biomolecules, such as a first biomolecule and a second biomolecule, are conjugated to a silica-type porous core as at least two of the formed silica-type biomolecule carriers. Different bioactive moieties, such as a first bioactive moiety and a second bioactive moiety. The two biomolecules or bioactive moieties are not identical to each other, but are functionally related and joined to the porous core by one or more linkers.

[0019] As used he...

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PUM

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Abstract

Silica-based biomolecule carriers, compositions comprising the same and preparation methods and uses thereof for delivering biomolecules into a cell are provided. The silica-based biomolecule carriercomprises a porous core; a first bioactive moiety; a second bioactive moiety functionally associated with the first bioactive moiety; and linkers for respectively conjugating the first bioactive moiety and the second bioactive moiety to the porous core.

Description

technical field [0001] Generally speaking, the present invention relates to a biomolecular carrier, in particular to a silica-type biomolecular carrier, a composition containing it, a preparation method and use thereof. Background technique [0002] In order to solve the poor solubility and other delivery problems of drugs and biomolecules, various carriers have been developed in the past decade, hoping to deliver therapeutic agents to target sites in the body. For example, silica-based supports such as hollow silica nanospheres (HSNs) and mesoporous silica nanoparticles (MSNs) are suitable for the delivery of agents due to their favorable chemical properties, thermal stability, and biocompatibility. [0003] Drug- or biomolecular-conjugated silica-based materials derived from HSNs or MSNs are one of the most promising approaches in cancer therapy and the treatment of various challenging diseases. In addition, silica-type carriers can also be used in enzyme replacement ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08K5/5415G01N33/552A61K39/385
CPCA61K47/62A61K47/6925A61K39/385G01N33/552G01N2333/163A61K47/6929A61K47/6923A61P3/00A61P35/00A61P43/00
Inventor 牟中原陈奕平吴思翰
Owner 牟中原