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Method for extracting gypenosides

A technology of Gynostemma pentaphyllum and Gynostemma pentaphyllum powder is applied in pharmaceutical formulations, medical preparations containing active ingredients, antidote and other directions, which can solve the problems of decreased curative effect, lack of total glycosides, low yield, etc., so as to reduce the loss rate and ensure high activity. and high quality, the effect of improving the purity

Inactive Publication Date: 2018-08-17
刘哲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of the present invention is to provide a method for extracting Gypenosides, which is used to solve the problems of high cost, low yield, and lack of total glycosides in the existing extraction process of Gypenosides, which lead to a decline in curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The invention provides a method for extracting gypenosides, the method comprising the steps of:

[0054] Step (1): Pulverize the Gynostemma pentaphylla medicinal material to obtain Gynostemma pentaphyllum powder; the particle size of the Gynostemma pentaphyllum powder is 2-10 mesh.

[0055] The 2nd step: put the Gynostemma pentaphyllum powder that the 1st step obtains in ethanol and extract, obtain filtrate;

[0056] Step (2.1): put Gynostemma pentaphyllum powder into the extraction tank, add ethanol with a volume fraction of 80%, and impregnate; after soaking for 6 hours, discharge the medicinal liquid and filter to obtain the medicinal liquid; The fraction is 80% ethanol, dipped for 5 hours, filtered to obtain the medicinal liquid; merge the secondary medicinal liquid, and set aside;

[0057] Step (2.2): add ethanol with a volume fraction of 80% to carry out the third and fourth impregnations, respectively, for 5 hours; the medicinal solution is combined after coarse...

Embodiment 2

[0076] The invention provides a method for extracting gypenosides, the method comprising the steps of:

[0077] Step (1): Pulverize the Gynostemma pentaphylla medicinal material to obtain Gynostemma pentaphyllum powder; the particle size of the Gynostemma pentaphyllum powder is 2-10 mesh.

[0078] The 2nd step: put the Gynostemma pentaphyllum powder that the 1st step obtains in ethanol and extract, obtain filtrate;

[0079] Step (2.1): put Gynostemma pentaphyllum powder into the extraction tank, add ethanol with a volume fraction of 60%, and impregnate; after soaking for 4 hours, discharge the medicinal liquid and filter to obtain the medicinal liquid; The fraction is 60% ethanol, dipped for 3 hours, filtered to obtain the medicinal liquid; combine the secondary medicinal liquid, and set aside;

[0080] Step (2.2): add ethanol with a volume fraction of 60% to carry out the third and fourth impregnations, respectively, for 3 hours; the medicinal solution is combined after coar...

Embodiment 3

[0099] The invention provides a method for extracting gypenosides, the method comprising the steps of:

[0100] Step (1): Pulverize the Gynostemma pentaphylla medicinal material to obtain Gynostemma pentaphyllum powder; the particle size of the Gynostemma pentaphyllum powder is 2-10 mesh.

[0101] The 2nd step: put the Gynostemma pentaphyllum powder that the 1st step obtains in ethanol and extract, obtain filtrate;

[0102] Step (2.1): put Gynostemma pentaphyllum powder into the extraction tank, add ethanol with a volume fraction of 85%, and impregnate; after soaking for 8 hours, discharge the medicinal liquid and filter to obtain the medicinal liquid; Ethanol with a fraction of 85%, soaked for 7 hours, and filtered to obtain the medicinal solution; combine the secondary medicinal solutions for subsequent use;

[0103] Step (2.2): Add ethanol with a volume fraction of 85% to carry out the third and fourth impregnations, respectively, for 7 hours; the medicinal solution is com...

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Abstract

The invention discloses a convenient, systematic and integrated method for extracting gypenosides. The method comprises the following steps: (1) performing pretreatment on fiveleaf gynostemma herb; (2) lixiviating the fiveleaf gynostemma herb powder in ethanol to obtain filtrate; (3) performing resin pretreatment; (4) performing column chromatography to obtain gypenosides powder; (5) eluting impurities adsorbed by resin by using a resin regeneration solution so as to recover original composition and performance. Through a continuous no-difference separation cooperation process of medicinal material pretreatment, lixiviating, resin pretreatment, column chromatography and resin regeneration, the method has the advantages of high separation efficiency, stable separation process and convenience in quality control, and can obtain the gypenosides of target quantity through control on partial links.

Description

technical field [0001] The invention relates to the technical field of extraction of effective components of traditional Chinese medicinal materials, in particular to a method for extracting total glycosides of gypenosides. Background technique [0002] Gypenosides have the effects of lowering blood fat, improving myocardial ischemia and hypoxia, protecting against cerebral ischemia, and anti-oxidation. Nourishes the heart and strengthens the spleen, replenishes qi and blood, removes phlegm and removes blood stasis. It is suitable for hyperlipidemia, palpitations, shortness of breath, chest tightness, numbness, dizziness, headache, forgetfulness, tinnitus, spontaneous sweating, fatigue, or abdominal fullness. Phlegm blocking blood stasis. [0003] Pharmacological action of Gypenosides: The main components of the drug are Gypenosides. It has the effects of lowering blood fat, anti-platelet aggregation, anti-myocardial ischemic injury, anti-aging, etc., the details are as fo...

Claims

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Application Information

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IPC IPC(8): A61K36/424A61P3/06A61P9/10A61P39/06
CPCA61K36/424A61K2236/15A61K2236/333A61K2236/55A61P3/06A61P9/10A61P39/06
Inventor 刘哲
Owner 刘哲
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