Biomarker and detection method for detecting risk of cancer recurrence

A biomarker and risk technology, applied in biochemical equipment and methods, microbial determination/examination, DNA/RNA fragments, etc., can solve the complex molecular biology network mechanism of prostate cancer and the risk assessment of prostate cancer recurrence in prostate cancer patients Problems such as lack of hierarchical grouping

Active Publication Date: 2018-08-21
SHENZHEN YIKANG BIOTECH CO LTD
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a lot of important progress has been made in the study of prostate cancer biomarkers, the risk assessment of recurrence after radical prostatectomy and the strat...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biomarker and detection method for detecting risk of cancer recurrence
  • Biomarker and detection method for detecting risk of cancer recurrence
  • Biomarker and detection method for detecting risk of cancer recurrence

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0033] In order to describe the technical content, achieved goals and effects of the present invention in detail, the following descriptions will be made in conjunction with the embodiments and accompanying drawings.

[0034] Genomic alterations based on the 25-gene MUC1 gene network are slightly associated with prostate cancer recurrence. On this basis, the inventors proved that genomic alterations in 9 of these 25 genes can significantly enhance this association. The present invention aims to take full advantage of the potential value of MUCl as a novel biomarker to develop an effective signature gene combination to predict the recurrence of prostate cancer. In the innovative work, the inventors discovered 696 differentially expressed genes (DEGs) in cBioPortal's prostate cancer TCGA clinical database, which were associated with a 9-gene characteristic genome. The inventors further constructed 15 characteristic genomes and multiple subgroups from these differentially express...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a biomarker and detection method for detecting the risk of cancer recurrence, wherein the biomarker for detecting the risk of cancer recurrence comprises at least one of the following genes: SLCO2A1, CGNL1, SUPV3L1, TATDN2, MGAT4B, VAV2, SLC25A33, MCCC1, ASNS, CASKIN1, DNMT3B, AURKA, OIP5, CTHRC1 and GOLGA7B. The biomarker for detecting the risk of cancer recurrence, provided by the invention, has an advantage of effectively predicting the recurrence risk of cancers such as prostate cancer and the like.

Description

technical field [0001] The invention relates to prostate cancer detection technology, in particular to a biomarker for detecting the risk of cancer recurrence and a method for detecting the risk of cancer recurrence. Background technique [0002] Prostate cancer is the most common malignant tumor among men in developed countries, and the incidence of prostate cancer is also rising rapidly in China. The progression of different prostate cancers varies widely. Although most low-score tumors (Gleason score less than 6 / WHO grade (group) I) have good long-term prognosis, about 30% of tumors recur after radical prostatectomy. The main indicator of this type of cancer recurrence is elevated serum prostate-specific antigen (PSA), also known as biochemical recurrence. Elevated serum prostate-specific antigen predicts high-risk metastases. The standard treatment for metastatic prostate cancer is androgen deprivation therapy (ADT), which is a palliative treatment. After the failure...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 唐大木何立智陈争陈婧赵坤成赵凤娟曾永柯马靖翔
Owner SHENZHEN YIKANG BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap