Spray photosensitizer composition for photodynamic therapy to treat diseases of nasal and laryngopharyngeal cavities

A technology of photodynamic therapy and photosensitizer, which is applied in the field of biomedicine, can solve the problems of irregular shape of nasopharyngeal and throat cavity, uneven application of gel preparations, and uneven drug release speed, so as to achieve good absorption promotion effect and improve Good bioavailability and water solubility

Inactive Publication Date: 2018-08-24
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the gel preparation is administered to the nasopharynx, there is a phenomenon of uneven administration
The main reason for this phenomenon is that the shape of the nasopharyngeal and throat cavity is irregular, and the gel preparation cannot be evenly applied on the nasopharyngeal and throat mucous membranes, so the drug release rate of the gel preparation is different in different parts of the nasopharyngeal and throat mucous membranes.
And gel formation generally requires a higher concentration of polymer materials and some non-aqueous solvents, so the stimulation to the body is also a problem
The difference in the temperature of the nose and throat of different patients will also cause the liquefaction time of the gel and the release rate of the drug in the medicine to be different, which increases the difficulty of the operator's operation and leads to unstable treatment effect
Therefore, clinically, it is still difficult to realize

Method used

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  • Spray photosensitizer composition for photodynamic therapy to treat diseases of nasal and laryngopharyngeal cavities
  • Spray photosensitizer composition for photodynamic therapy to treat diseases of nasal and laryngopharyngeal cavities
  • Spray photosensitizer composition for photodynamic therapy to treat diseases of nasal and laryngopharyngeal cavities

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 5-aminolevulinic acid photosensitizer nasal spray 1

[0046] prescription:

[0047] 5-aminolevulinic acid

[0048] Preparation method: fully mix and dissolve the 5-aminolevulinic acid, dimethyl-β-cyclodextrin, sodium chloride, paraben, and polyethylene glycol 4000 in the above prescription amount, and adjust the pH to 5 with acetic acid After .5-7.5, add water for injection to 100mL to make a clear solution.

Embodiment 2

[0050] 5-aminolevulinic acid photosensitizer nasal spray 2

[0051]

[0052]

[0053] Preparation method: Mix and dissolve the 5-aminolevulinic acid, Tween-80, sodium chloride, sorbic acid, and polyethylene glycol 4000 in the above prescription amount, adjust the pH to 5.5-7.5 with acetic acid, and then inject Make up to 100mL with water to make a clear solution. The specific ingredients of the penetration enhancer and preservative used in this formula are different from the previous formula.

[0054] Implementation 3

[0055] 5-aminolevulinic acid photosensitizer nasal spray 3

[0056] 5-aminolevulinic acid

[0057] Preparation method: Fully mix and dissolve the 5-aminolevulinic acid and dimethyl-β-cyclodextrin in the above prescription amount, adjust the pH to 5.5-7.5 with acetic acid, add water for injection to 100mL, and make a clear solution . This recipe has no preservatives.

Embodiment 4

[0059] The dose of the 5-aminolevulinic acid photosensitizer nasal spray 1 provided by the present invention is within the range of 1-3 mL each time. In order to verify the efficacy of the provided 5-aminolevulinic acid photosensitizer nasal spray, with reference to the nasal throat gel formulation in CN102670577A, the gel formulation of 5-aminolevulinic acid was used as a contrast, and the control group used 5- The formulation of the gel preparation of aminolevulinic acid is 5g of 5-aminolevulinic acid, 1.667g of hydroxypropylmethylcellulose (HPMC) and 20mL of water for injection. In this experiment, mice were used as experimental animals to carry out skin absorption experiments: after the cuticle of the mouse epidermis was removed with erbium laser (2J / CM2), the mice were placed in a light-tight mouse box, and the experimental group was treated with a sprayer. The superficial skin of mice was administered at a dose of 100 μl / cm 2 , Adjust the number of administration accord...

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PUM

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Abstract

The invention discloses a spray photosensitizer composition for photodynamic therapy to treat diseases of nasal and laryngopharyngeal cavities. The spray photosensitizer composition contains a photosensitizer, a penetration enhancer and a pH regulator, and can further comprise an osmotic pressure adjuster, a preservative, a thickener, a humectant, and the like. The spray photosensitizer preparation for nasal and laryngopharyngeal cavities is absorbed by nasal and laryngopharyngeal mucosae and enters focus parts of the nasal and laryngopharyngeal cavities to play a role, has the advantages of controllable dosage, controllable quality and no irritation to the mucosae, and can be widely applied to the treatment of diseases of nasal and laryngopharyngeal cavities by photodynamic therapy.

Description

technical field [0001] The invention relates to a nasal and throat spray drug delivery preparation, in particular to a spray photosensitizer used for photodynamic therapy for treating diseases of the nasal cavity and throat, and belongs to the field of biomedicine. Background technique [0002] Photodynamic therapy (Photodynamic Therapy, PDT) has become a routine treatment for tumors and skin diseases. It is widely used in nasopharyngeal and throat tumors and nasopharyngeal carcinoma. PDT has good curative effect on nasopharyngeal and throat benign tumors, nasopharyngeal and throat early malignant tumors, early nasopharyngeal carcinoma, and recurrent nasopharyngeal and throat malignant tumors and nasopharyngeal carcinoma. PDT uses photosensitive drugs and specific wavelengths of visible light to generate pure oxygen, causing oxidative damage in target tissues, and can target and destroy local target tissues with little damage to normal tissues. [0003] In PDT, a photosensi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K41/00A61P11/02A61P11/04
CPCA61K9/0043A61K9/12A61K41/0061A61K47/36A61K47/40A61P11/02A61P11/04
Inventor 柳岸彭亚宋相志刘波黄利华康健王臻肖哲鹏李卓钰龙可欣赵海福
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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