Online solid phase extraction liquid chromatography method for detecting clonazepam content in blood

A clonazepam and chromatographic analysis technology is applied in the field of clinical blood drug concentration monitoring of psychotropic drugs, which can solve the problems of long analysis time and complicated pretreatment, and achieves shortening analysis time, reducing toxic and side effects, and reducing personnel operations. Effect
CN108445113AActive Publication Date: 2018-08-24BEIJING HARMONY HEALTH MEDICAL DIAGNOSTICS CO LTD
7 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING HARMONY HEALTH MEDICAL DIAGNOSTICS CO LTD
Publication Date
2018-08-24

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an online solid phase extraction liquid chromatography method for detecting clonazepam content in blood. The method is to calibrate a standard solution by using high performance liquid chromatograph and a DVD detector, a standard curve equation obtained is y=a*x+b, a blood sample to be tested is taken, after the blood to be tested is processed, the sample to be tested is also detected by using the high performance liquid chromatograph and the DVD detector, a blood y value to be tested is obtained, the blood y value to be tested is substituted into the standard curve equation, the relative concentration x of clonazepam is calculated in the blood sample to be tested, and the concentration of internal standard working fluid is known, thereby calculating the concentration of the clonazepam in the blood to be tested in the sample; the serum of the method is directly injected after sedimentation and centrifugation, which makes the detection process simple and rapid, the experimental cost is reduced, and the method is more conducive to monitoring the blood concentration of the clonazepam in a patient during clinical treatment.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of clinical blood drug concentration monitoring of psychotropic drugs, in particular to a method for detecting the concentration of clonazepam, an antiepileptic and anticonvulsant drug in blood. Background technique

[0002] Epilepsy is a common neurological disease characterized by sudden and recurrent seizures. Currently, drug therapy is the first choice in clinical practice. Clonazepam is a broad-spectrum antiepileptic drug, used to control various types of epileptic seizures, and has a better effect on absence seizures, infantile spasms, myoclonic and akinetic seizures. It can also be used in the treatment of drug-induced attention deficit disorder (hyperactivity disorder) and various neuralgia. The active compound circulating in the blood is clonazepam after it passes through the gastrointestinal tract after oral administration. Clonazepam (Clonazepam, CZP), the molecular formula is C 15 h 10 ClN 3...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More