Adrenocorticotropic hormone (ACTH) chemiluminescence detection kit

Abstract

The invention discloses an adrenocorticotropic hormone (ACTH) chemiluminescence detection kit, which comprises a reagent (1) and a reagent (2). The reagent (1) comprises a buffer solution, magnetic particles, a biotin labeled anti-ACTH monoclonal antibody, and polyhydric alcohol. The reagent (2) comprises a buffer solution, an acridinium ester labeled anti-ACTH monoclonal antibody and polyhydroxylsaccharides. The provided kit has the advantages of good stability, high sensitivity, good accuracy, simple and convenient operation, and low cost, and is not influenced by rheumatoid factors.

Description

technical field

[0001] The invention relates to the field of in vitro diagnostic reagents, in particular to a corticotropin chemiluminescence detection kit. Background technique

[0002] Adrenocorticotropic hormone (ACTH) is a peptide hormone composed of 39 amino acids with a molecular weight of about 4.5kD. Adrenocorticotropic hormone is produced in the pituitary gland and acts on the adrenal cortex to promote the proliferation of adrenal cortical tissue and the production and secretion of corticosteroids. The secretion of corticotropin is regulated by many factors such as hypothalamic corticotropin releasing factor (CRH), cortisol, and self-negative feedback.

[0003] Corticotropin testing is valuable in the differential diagnosis of adrenal insufficiency and hypersecretion. Increased corticotropin levels seen in: Addison disease (primary adrenal insufficiency), corticotropin insensitivity syndrome and corticotropin receptor abnormalities, Cushing disease secondary to pi...

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