A preparation method and application of a dimeform sensor based on a cobalt-based nitride nanoarray

A nano-array and nano-sheet array technology, which is applied in the field of new nano-functional materials and biosensing analysis, can solve the problems of reduced sensitivity, reduced stability and reproducibility of electrochemical sensors, and limitations on the application of molecularly imprinted membranes, and achieves excellent results. Electron transfer ability, convenient operation, and the effect of reducing detection cost

Active Publication Date: 2021-02-19
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electrochemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

Method used

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  • A preparation method and application of a dimeform sensor based on a cobalt-based nitride nanoarray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]Example 1 Preparation of CoNiN-nanoarray

[0030](1) Use dilute hydrochloric acid, absolute ethanol and deionized to clean the disposable electrode with ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0031](2) Weigh 1 mmol Ni(NO3)2And Co(NO3)2And 3 mmol urea CO(NH2)2, Put it into a 50mL beaker, add 30mL deionized water and stir until it is clear, then transfer it to a 50mL PTFE reactor;

[0032](3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), and react at 100°C for 12 hours to prepare cobalt-nickel bimetal layered hydrogen Oxide nanosheet array precursor electrode;

[0033](4) Insert the cobalt-nickel bimetal layered hydroxide nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at a temperature of 20 ℃ After 4 hours, take it out and immerse it in deionized...

Embodiment 2

[0035]Example 2 Preparation of CoNiN-nanoarray

[0036](1) Use dilute hydrochloric acid, absolute ethanol and deionized to clean the disposable electrode with ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0037](2) Weigh 2 mmol Ni(NO3)2And Co(NO3)2And 6 mmol urea CO(NH2)2, Put it into a 50mL beaker, add 30mL deionized water and stir until it is clear, then transfer it to a 50mL PTFE reactor;

[0038](3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), and react at 110°C for 11 hours to prepare cobalt-nickel bimetal layered hydrogen Oxide nanosheet array precursor electrode;

[0039](4) Insert the cobalt-nickel bimetallic layered hydroxide nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at a temperature of 30 ℃ After 5 hours, take it out and immerse it in deioni...

Embodiment 3

[0041]Example 3 Preparation of CoNiN-nanoarray

[0042](1) Use dilute hydrochloric acid, absolute ethanol and deionized to clean the disposable electrode with ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0043](2) Weigh 3 mmol Ni(NO3)2And Co(NO3)2And 9 mmol urea CO(NH2)2, Put it into a 50mL beaker, add 30mL deionized water and stir until it is clear, then transfer it to a 50mL PTFE reactor;

[0044](3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), and react at 130°C for 9 hours to prepare cobalt-nickel bimetal layered hydrogen Oxide nanosheet array precursor electrode;

[0045](4) Insert the cobalt-nickel bimetallic nitride nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at 40 ℃ for 6 hours. , Taken out and immersed in deionized water 4 times to prepare CoN...

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Abstract

The invention discloses a preparation method of a dimeform sensor based on a cobalt-based nitride nano-array. It belongs to the field of new nano functional material and biosensing analysis technology. In the present invention, a cobalt-nickel double-metal nitride nanosheet array is firstly prepared on a disposable disposable electrode, and by using its large specific surface area and high adsorption activity to amino groups, as well as the amino functional group of polydopamine, an in-situ growth method is adopted. Polydopamine films containing electron mediators and molecularly imprinted polymers with dimeform as template molecules were directly and successively prepared on the cobalt-nickel double metal nitride nanosheet arrays. After the template molecules were eluted, the original template molecules The position of the hole becomes a hole, that is, the molecularly imprinted polymer that elutes the template molecule. Thus, a cobalt-based nitride nanoarray-based sensor for dimeform is prepared.

Description

Technical field[0001]The invention relates to a preparation method and application of an electrochemical analysis sensor. It belongs to the field of new nano-functional materials and biosensing analysis technology.Background technique[0002]Methamidine, also known as ampicillin, is a β-lactam antibiotic. It is a semi-synthetic broad-spectrum penicillin that can treat a variety of bacterial infections. Indications include respiratory tract infection, urinary tract infection, meningitis, salmonella infection, and endocarditis. Because of its convenient use and low cost, it is mostly used to treat infectious diseases caused by sensitive chicken bacteria, such as Escherichia coli, Salmonella, Pasteurella, Staphylococcus and Streptococcus infections. On October 27, 2017, in the list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization, ampicillin was included in the list of three carcinogens. Therefore, the development of a rapid, hi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327
CPCG01N27/26G01N27/30G01N27/3278
Inventor 张勇刘召壹杜斌
Owner UNIV OF JINAN
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