Docetaxel-absolute ethyl alcohol tumor embolization agent and preparation method thereof

A technology of anhydrous ethanol and docetaxel, which is applied in pharmaceutical formulations, surgical adhesives, applications, etc., can solve problems affecting people's health and rising medical expenses, and achieve the effect of easy disinfection and improved curative effect

Inactive Publication Date: 2018-09-28
无锡紫杉药业股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This not only seriously affects people's health, but ...

Method used

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Embodiment 1

[0022] A preparation method of docetaxel-dehydrated alcohol tumor embolization agent, described method comprises the steps:

[0023] (1) Take 30g of sodium alginate to make sodium alginate microspheres, dissolve in 5000ml of dehydrated ethanol to obtain solution A for subsequent use;

[0024] (2) Get 20 g of docetaxel and dissolve it in 3000 ml of absolute ethanol to obtain solution B for subsequent use;

[0025] (3) Put solution A, solution B and the remaining 2000ml of absolute ethanol in the batching tank, stir to dissolve it completely, add 5% (w / v) citric acid ethanol solution to adjust the pH to between 5.5-6.5 Add 0.03% (w / v) activated carbon for needles, stir and absorb for 20 minutes, then connect a titanium rod filter and two 0.22μm microporous membranes in series to filter, and collect the filtrate to fill the liquid medicine barrel;

[0026] (4) Adjust the stoppering position of the filling machine so that it is at the full stoppering station, divide the filling v...

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Abstract

The invention discloses a docetaxel-absolute ethyl alcohol tumor embolization agent and a preparation method thereof. The raw materials of the tumor embolization agent are composed of docetaxel, sodium alginate and absolute ethyl alcohol. The docetaxel-absolute ethyl alcohol tumor embolization agent and the preparation method thereof have the advantages that the hardening and chemical ablation effects of the absolute ethyl alcohol are utilized to load the antitumor drug docetaxel and self-developed sodium alginate microspheres, and the prepared embolization agent can embolize peripheral bloodvessels, can occlude blood vessels with different apertures and different flow quantities, and is transported easily through a catheter, obtained easily and disinfected easily; antitumor drug-docetaxel can be effectively carried to arrive into tumor blood supplying vessels and slowly released in the local tumor, thereby improving the curative effect of tumor interventional embolization treatment.

Description

technical field [0001] The invention relates to the technical field of medicine development, in particular to a tumor embolism agent mainly composed of docetaxel and absolute ethanol and a preparation method thereof. Background technique [0002] At present, 1 out of every 5 deaths in our country is due to cancer; among the population aged 0-64, 1 out of every 4 deaths is due to cancer. This not only seriously affects people's health, but also becomes an important factor in rising medical expenses. The medical expenses for cancer patients are nearly 100 billion yuan every year. [0003] The current main routine methods of tumor treatment include traditional surgery, chemotherapy, radiotherapy, and targeted therapy. Tumor interventional therapy is one of the more popular and effective treatment methods for advanced tumors. In interventional therapy, transcatheter Arterial infusion chemotherapy (Transcatheter arterial infusion; TAI) and transcatheter arterial chemoembolizati...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/0015A61L24/0042A61L24/08A61L2300/416A61L2400/06C08L5/04
Inventor 田连忠喻琼林汤伟彬刘雷
Owner 无锡紫杉药业股份有限公司
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