Individual cervical cancer prognosis evaluation method based on poly-gene expression characteristic spectrum

A technology of gene expression profiling and expression signature, applied in the field of personalized prognosis assessment of cervical cancer based on multi-gene expression profiling

Active Publication Date: 2018-10-02
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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Problems solved by technology

However, most reports only use single or several genes, can only classify a group, and can only qualitatively divide the individual survival period (such as two indicators of good prognosis and poor prognosis)

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  • Individual cervical cancer prognosis evaluation method based on poly-gene expression characteristic spectrum
  • Individual cervical cancer prognosis evaluation method based on poly-gene expression characteristic spectrum
  • Individual cervical cancer prognosis evaluation method based on poly-gene expression characteristic spectrum

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Embodiment Construction

[0060] The implementation of the present invention will be described in detail below with examples, so as to fully understand and implement the implementation process of how the present invention uses technical means to solve technical problems and achieve technical effects.

[0061] The invention discloses a method for evaluating the individualized prognosis of cervical cancer based on a polygene expression profile, comprising the following steps:

[0062] Step 1. Obtain the list of cervical cancer prognosis risk genes and gene weights, specifically:

[0063] Step 1.1, download the transcriptome data and clinical data of tumor tissue and paracancerous tissue of cervical cancer patients from the Genomic Data Commons Data Portal database, and obtain the tumor tissue gene expression profile FPKM of cervical cancer patients ( F fragments P er K ilobase of transcript per M million fragments mapped) values, logarithmic transformation (log2).

[0064] Step 1.2, set the total num...

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Abstract

The invention discloses an individual cervical cancer prognosis evaluation method based on a poly-gene expression characteristic spectrum. The method comprises the following steps: acquiring a cervical cancer prognosis risk gene table and a gene weight; establishing a prognosis evaluation model by using cervical cancer patient tumor tissue transcriptome and survival data; according to a gene expression spectrum of tumor tissue of a patient suffering from cervical cancer, calculating a risk score of the patient; according to the risk score of the patient, calculating a survival probability of the patient each year. By adopting the method disclosed by the invention, the survivals probability of the patient suffering from cervical cancer each year is highly accordant with an actual survival rate each year (linear relationship R2=0.988, a P value=5.04E-38). Tests show that the method has very high prediction accuracy, and is highly coincided with an actual survival state. Meanwhile, for each tumor patient, a unique survival probability of the patient can be drawn by using the method.

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and in particular relates to a personalized prognosis evaluation method for cervical cancer based on multi-gene expression profiles. Background technique [0002] Cervical cancer is a malignant tumor with high incidence among women in China and around the world. The morbidity and mortality of cervical cancer in developing countries are higher than those in developed countries worldwide, and the incidence of cervical cancer in developing countries is second only to breast cancer. Global Burden of Disease (GBD) data shows that in 2016, the number of people suffering from cervical cancer worldwide reached 1.94 million, of which 350,000 were in China. In 2016, the number of deaths of cervical cancer patients worldwide was 250,000, accounting for 0.45% of the total deaths. In 2016, the number of patients who died in China was 38,000, accounting for 0.40% of the total number of deaths. Sta...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 李文兴李功华黄京飞赵旭东代绍兴
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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