A sample tube fixture for magnetic resonance imaging

Abstract

The invention discloses a sample tube fixing device for magnetic resonance imaging. The device comprises a base and a grid assembly for containing sample tubes; the base comprises a main base body andan elastic body which is arranged on the side surface of the main base body in the circumferential direction and used for fixing the base in a magnetic resonance coil; the grid assembly is arranged on the upper end face of the main base body and comprises a grid formed by arranging a plurality of unit grids, all the unit grids are same in shape and structure and are columnar cylinders, and an inner hole of each columnar cylinder is a tapered hole the hole diameter of which gradually gets smaller from outside to inside. The sample tube fixing device for magnetic resonance imaging has good compatibility and is suitable for various sample tubes different in type, the position of the base in the magnetic resonance coil can be adjusted through an arranged scale rod, it is ensured that the excellent magnetic resonance imaging effect is achieved, and besides, the device can also meet various magnetic resonance testing requirements under the conditions of different magnetic resonance coils.

Description

technical field [0001] The invention belongs to the technical field of magnetic resonance imaging, and relates to a sample tube installation and support device used in magnetic resonance imaging analysis. Background technique [0002] Magnetic resonance in vitro imaging refers to the magnetic resonance imaging research on polymer paramagnetic and diamagnetic materials, human and animal isolated tissues and organs, and cultured cells. It is mainly used in various imaging at the cellular and molecular levels, including gene expression. Transmission imaging, cell tracking, tumor molecular imaging, and research on biomedical medicinal materials; it also plays a unique role in the development and research of new drugs. [0003] In order to avoid biochemical contamination, the test samples are generally put into sample tubes for MRI analysis. When analyzing multiple test samples, it is necessary to first assemble the sample tubes containing multiple test samples to form a group o...

AI Technical Summary

Problems solved by technology

Since the current magnetic resonance imaging system is not equipped with standard sample tube assembly accessories, users generally use test tube racks, sponge foam, cardboard, etc. to fix the tube group to be tested in the coil of the magnetic resonance system; for example (1) He Yonglan et al. In the magnetic resonance imaging of pancreatic cancer cells with molecular target nano-iron oxide particles, centrifuge tubes (a type of test tube) are placed horizontally on the test tube rack, and then fixed on the magnetic resonance coil with adhesive tape, so that multiple centrifuges The test tube group composed of tubes is fixed on the magnetic resonance coil (magnetic resonance imaging of pancreatic cancer cells with molecular target nano-iron oxide particles, He Yonglan, doctoral thesis, Peking Union Medical College, 2010), directly using the test tube rack , there are restrictions on the selection of magnetic resonance coils, and sometimes it is necessary to remodel the test tube rack to adapt to the aperture size of different coils. In addition, if the test tube rack is not full of test tubes, there will be large gaps between the test tubes, which will affect the later stage. Magnetic resonance imaging causes artifact interference, and different types of test tubes require matching test tube racks, which not only increases costs, but also causes waste of resources; The sample tubes containing the isolated specimens were fixed on the self-made sponge holder, and then the sponge holder was placed on the magnetic resonance coil to achieve the purpose of fixing multiple sample tubes at the same time (magnetic resonance imaging examination technology of isolated samples, Chen Zhian et al. , Chinese Journal of Oncology, July 2002, Vol. 18, Vol. 7: 710-711), because the sponge support needs to be drilled and edge trimmed by itself, and sufficient gaps should be left between the holes of each sample tube, such a structure is not conducive to the later stage. The image signal-to-noise ratio is improved during the magnetic resonance imaging process, and the sponge holder is easily deformed after a long time of use, which cannot ensure the stability in the magnetic resonance coil. In addition, each sample tube hole on the sponge holder also lacks versatility; (3) In the quantitative effect of two kinds of ultra-small superparamagnetic iron oxide nanoparticles disclosed by J.C.Brisset et al. on the internalization of cells at 4.7T and 7T, multiple test tubes containing cultured cells were simply wrapped and combined and placed directly in magnetic resonance. In the coil (Quantitative effects of cellinternalization of two types of ultrasmall superparamagnetic iron oxidenanoparticles at 4.7T and 7T, J.C.Brisset et al., Eur Radiol, August 25, 2009, 2010 Volume 20: 275-285), this placement method, Due to the existence of the top cover of the test tube, it is impossible to ensure that the long axes of each test tube are in a completely parallel direction, which may result in different sizes and shapes of the magnetic resonance images of the same layer of the test tube group, which seriously affects the reliability of imaging data.

In a word, the fixing method of the above-mentioned test tube group in the magnetic resonance coil is due to the position of the sample tube in the magnetic resonance coil (such as close to the center or edge of the coil), the long axis direction of the sample tube and the main magnetic field B 0 Due to the influence of various factors such as the angle of the direction, the density of the tube group to be measured (that is, the number of sample tubes within the coil cross section), the image data consistency cannot be maintained during the MRI process, and it will directly affect the post-processing analysis of the image. In addition, slight vibration is unavoidable in the process of magnetic resonance imaging, and the above various fixing methods cannot guarantee that the tube group under test will not be displaced in the magnetic resonance coil. If there is a deviation between the tube group under test and the center of the magnetic resonance coil, then It is necessary to adjust the position of the tube group to be tested again; especially when performing MRI imaging of a large number of samples, this will not only increase the workload of scientific researchers to adjust the position of the sample tubes, but also the reliability of the obtained MRI data is difficult to guarantee

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