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A kind of application of aralia saponin ⅳ

A technology of Aralis longiae and Ariala saponin, which is applied in the field of medicines, compounds that can promote the proliferation and mineralization of primary osteoblasts, and can solve the problems of few research applications and the like.

Active Publication Date: 2020-04-10
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Tarasaponin IV (Tarasaponin IV) is extracted from Araliaceae (Araliaceae) Aralia plants, a compound that is less researched and applied, and the research content is only limited in the research There are studies on the damage protection of aralia saponin Ⅳ to cardiomyocytes, research on the anti-inflammatory activity of aralia saponin Ⅳ, etc., and there are studies on the effect of aralia saponin Ⅳ on promoting the proliferation and mineralization of primary osteoblasts that have not been published. Relevant content that affects the function

Method used

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  • A kind of application of aralia saponin ⅳ
  • A kind of application of aralia saponin ⅳ
  • A kind of application of aralia saponin ⅳ

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Embodiment Construction

[0015] The technical solution of the present invention will be clearly and completely described below in conjunction with specific embodiments. Apparently, the described embodiments are only a part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0016] (1) Tarasaponin IV can promote the proliferation and mineralization of primary osteoblasts as follows:

[0017] 1 Materials and Instruments

[0018] 1.1 Animals

[0019] 10 newborn 24h SD rat suckling mice (male) were provided by Peking University Medical Center (Department of Experimental Animal Science). License number: SCXK-(Beijing) 2016-0010.

[0020] 1.2 Drugs and reagents

[0021] Rhizoma thorny root bark (Hubei Enshi Traditional Chinese Medicine Co., Ltd. batch number 0P 091101, identified by Profes...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of compound tarasaponin IV capable of promoting primary osteoblast multiplication and mineralizationfunctions. The invention provides new application of the tarasaponin IV, i.e., application of the tarasaponin IV in preparation of medicine for preventing or treating bone diseases. The result shows that the tarasaponin IV can promote the preosteoblast growth and increase the demand quantity on ALP, so that the ALP utilization rate is improved; the formation of osteoblast mineralized nodules is promoted; the bone matrix mineralization effect is improved, so that the tarasaponin IV can be used as an active ingredient for preparing the medicine for preventing or treating the bone diseases. The medicine can be any one form of tablets, pills, capsules or injections. The invention also provides a preparation method of the medicine.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to the application field of a compound capable of promoting the proliferation and mineralization of primary osteoblasts. [0002] technical background [0003] At present, Tarasaponin IV (Tarasaponin IV) is extracted from Araliaceae (Araliaceae) Aralia plants, a compound that is less researched and applied, and the research content is only limited in the research There are studies on the damage protection of aralia saponin Ⅳ to cardiomyocytes, research on the anti-inflammatory activity of aralia japonica Ⅳ, etc., and there are studies on the effect of aralia japonica Ⅳ on promoting the proliferation and mineralization of primary osteoblasts, etc. Relevant content that has an impact on the culturalization function. Contents of the invention [0004] The object of the present invention is to provide a new application of aralia saponin IV, that is, the application of aralia saponin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P19/10A61P19/00
CPCA61K31/58A61P19/00A61P19/10
Inventor 裴凌鹏李金诚燕梦云周文斌
Owner MINZU UNIVERSITY OF CHINA