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A kind of tablet containing febuxostat and preparation method thereof

A febuxostat tablet technology, applied in the field of febuxostat tablets and its preparation, can solve the problems of poor content uniformity, poor dissolution rate, poor pain tolerance of gout patients, etc., and achieve rapid pain index The effects of lightening, reducing gastrointestinal side effects, and good content uniformity

Active Publication Date: 2019-05-28
BEIJING VOBAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] According to the classification of biopharmaceuticals, febuxostat belongs to BCS Ⅱ (low solubility, high permeability). Since it is almost insoluble in water, the common oral solid preparations containing this active ingredient have poor dissolution rate and poor content uniformity. It is an important obstacle affecting its use and curative effect. In addition, due to the poor pain tolerance of gout patients, there is an urgent need for a fast-acting preparation with rapid release and rapid absorption.
[0008] Many published Chinese patents try to solve the above problems, but the methods adopted are relatively complicated, the effect is doubtful, and none of them solves the problem of quick action

Method used

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  • A kind of tablet containing febuxostat and preparation method thereof
  • A kind of tablet containing febuxostat and preparation method thereof
  • A kind of tablet containing febuxostat and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1 febuxostat tablet (40mg / sheet)

[0066]

[0067]Preparation method: take aluminum magnesium carbonate, anhydrous lactose, and croscarmellose sodium according to the above-mentioned prescription ratio, and mix evenly; take the prescription amount of febuxostat raw materials and polyvinylpyrrolidone, and put 100ml of 70% ethanol solution , stir and dissolve; spray this solution into the mixture of lactose monohydrate, corn starch and cross-linked carmellose sodium in the way of spray granulation to granulate, dry, sieve and granulate, add silicon dioxide and Magnesium stearate, mixed evenly, compressed into tablets, coated.

Embodiment 2

[0068] Embodiment 2 febuxostat tablet (20mg / sheet)

[0069]

[0070] Preparation method: with embodiment 1

Embodiment 3

[0071] Embodiment 3 febuxostat tablet (80mg / sheet)

[0072]

[0073] Preparation method: with embodiment 1

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PUM

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Abstract

The invention relates to a febuxostat-containing tablet and a preparation method thereof. The febuxostat-containing tablet is prepared from, by weight, 20-80 parts of febuxostat, 50-100 parts of hydrotalcite, 50-100 parts of lactose anhydrous, 5-10 parts of croscarmellose sodium, 5-10 parts of polyvinylpyrrolidone, 0.1-1 parts of silicon dioxide and 0.1-5 parts of magnesium stearate. Wetting agents are selected from water and ethyl alcohol or mixture of the water and the ethyl alcohol, and a gastric-dissolved film coating premix comprises 2-5 parts of coating agents.

Description

Technical field: [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a febuxostat tablet and a preparation method thereof. Background technique: [0002] The occurrence of gout is due to the excessive production of uric acid in the body and the decrease of the ability of the kidneys to clear it. The accumulation of uric acid in the body leads to the deposition of urate crystals in the joints and various organs. An increase in the proportion of purine-rich foods in the dietary structure can increase the incidence of gout, especially in middle-aged and elderly people, chronic cardiovascular disease and diabetes. [0003] The current treatment of gout is usually to promote uric acid excretion and inhibit uric acid production, and take appropriate measures to improve related symptoms. The generation of uric acid in the body is related to purine metabolism. At the end of the purine metabolism process, hypoxanthine gene...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/02A61K31/426A61P19/06
CPCA61K9/2009A61K31/426A61P19/06
Inventor 张卫锋李进司成桃
Owner BEIJING VOBAN PHARMA TECH CO LTD