Treatment and prevention of retinal vascular disease by photocoagulation
A technology of retinal blood vessels, retina, applied in the field of treatment or prevention of retinal vascular diseases and/or macular edema
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Embodiment 1
[0114] Example 1 - A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion
[0115] In an exemplary embodiment, a computational model of the propagation of retinal ischemia in diabetic retinopathy was developed. This model was used to analyze the consequences of various peripheral retinal photocoagulation patterns. This model views retinal ischemia as an unfavorable local feedback phenomenon, in which once a capillary is blocked, the probability of adjacent capillary blockage increases, resulting in an enlarged retinal ischemic area. In this model, areas of retinal ischemia tend to spread, increase in size over time, and are limited by oxygenated areas surrounding larger retinal vessels because retinal oxygenation interferes with adverse local feedback processes. Modeling retinal burns as a local source of oxygen, different sizes and patterns of burns have different effects on the propagation of retinal ischemia. Th...
Embodiment 2
[0119] Example 2 – Effect of Spot and Strip Laser Burn Density on Ischemia Progression
[0120] In another exemplary embodiment, the computational models described in Example 1 and in the Materials and Methods section were used to determine the effect of spot and band laser burn density on the progression of retinal ischemia. While common PRP uses laser burns with a typical size of 250-500 micrometers, computational modeling suggests that regularly patterned burns of much smaller size will effectively prevent the progression of capillary occlusion in diabetic retinopathy while causing less damage to retinal tissue. small damage.
[0121] Two basic patterns of laser burns with the same total ablated area of retinal tissue were tested (Fig. 2). One pattern consisted of square spot laser burns along arterioles and venules, each spot measuring 100 microns by 100 microns. Another test pattern was rectangular ribbon laser burns oriented perpendicular to arterioles and venules, e...
Embodiment 3
[0124] Example 3 - Effect of spot and area with laser burns on progression of ischemia
[0125] In another exemplary embodiment, the computational models described in Example 1 and in the Materials and Methods section were used to determine the effect of spots and areas with laser burns on the progression of retinal ischemia. N=4 ribbon and dot patterns were chosen for additional modeling to assess their efficacy in preventing ischemia propagation as a function of burn size (see Figure 4).
[0126] To assess the effect of simulated photocoagulation, the ischemic area at the end of the simulation was considered an important indicator of the severity of diabetes progression, although visual deficits according to the burn area were also considered. From this, the sum of the initial laser ablation area and the ischemic propagation area was estimated. Optimal photocoagulation was defined as the lowest sum of ischemic area due to capillary occlusion and area of tissue damage due ...
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