A method for preparing drug-loaded nanoparticles with core-shell structure
A drug-loaded nanometer, core-shell structure technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve problems such as applicability limitations, and achieve the effects of increasing emission sources, reducing initial drug release, and improving yield
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[0020] The method for preparing drug-loaded nanoparticles with a core-shell structure comprises the following steps:
[0021] (1) Take each piece of transparent glass slide and microfluidic chip. The microfluidic chip is provided with an external phase solution interface, an internal phase solution interface, and a side channel connected with the center of the microfluidic chip; fully clean it with cleaning tape slide glass and microfluidic chip, and corona activation treatment was performed on the slide glass and microfluidic chip for 3 minutes, then the slide glass and microfluidic chip were bonded together, and air-dried at 60°C (electric blast drying oven ) After 2h, the microfluidic chip fixed on the glass slide was obtained;
[0022] (2) Drop acetone on the outlet of the side channel of the microfluidic chip, insert one end of the capillary into the channel of the microfluidic chip to the center of the microfluidic chip, and then connect the capillary to the microfluidic...
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