A method for preparing drug-loaded nanoparticles with core-shell structure

A drug-loaded nanometer, core-shell structure technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve problems such as applicability limitations, and achieve the effects of increasing emission sources, reducing initial drug release, and improving yield

Active Publication Date: 2020-09-15
温州品卓生物科技有限公司
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Problems solved by technology

Therefore, the applicability of this device is greatly limited in applications

Method used

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  • A method for preparing drug-loaded nanoparticles with core-shell structure
  • A method for preparing drug-loaded nanoparticles with core-shell structure
  • A method for preparing drug-loaded nanoparticles with core-shell structure

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Embodiment Construction

[0020] The method for preparing drug-loaded nanoparticles with a core-shell structure comprises the following steps:

[0021] (1) Take each piece of transparent glass slide and microfluidic chip. The microfluidic chip is provided with an external phase solution interface, an internal phase solution interface, and a side channel connected with the center of the microfluidic chip; fully clean it with cleaning tape slide glass and microfluidic chip, and corona activation treatment was performed on the slide glass and microfluidic chip for 3 minutes, then the slide glass and microfluidic chip were bonded together, and air-dried at 60°C (electric blast drying oven ) After 2h, the microfluidic chip fixed on the glass slide was obtained;

[0022] (2) Drop acetone on the outlet of the side channel of the microfluidic chip, insert one end of the capillary into the channel of the microfluidic chip to the center of the microfluidic chip, and then connect the capillary to the microfluidic...

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Abstract

The invention discloses a method for preparing drug-carrying nanoparticles of a core-shell structure. The method comprises two parts, namely manufacture of a capillary micro-fluidic chip and preparation of nanoparticles. The invention firstly provides a micro-fluidic chip prepared from polydimethylsiloxane (PDMS) as the material for replacing the traditional coaxial syringe needle, taxol-carryingnanoparticles of the core / shell structure having the uniform particle size and narrow particle size distribution are prepared by combining with the coaxial electrostatic spraying method, the feasibility of the micro-fluidic chip for preparing drug-carrying nanoparticles is proved, and the problems that the nanoparticles prepared by the traditional method have the sudden release phenomenon and thePDMS array transmitter is not resistant to tetrahydrofuran, chloroform, acetone or other organic solvents are solved. Moreover, preparation of multilayer and composite structure nanoparticles can berealized.

Description

technical field [0001] The invention belongs to the technical field of nanoparticle preparation, and in particular relates to a method for preparing drug-loaded nanoparticle with a core-shell structure. Background technique [0002] Coaxial electrohydrodynamic atomization (CEHDA) is a new technology that can prepare polymer nanoparticles and microbubbles loaded with therapeutic drugs. Depending on the nature of the liquid, the liquid flow rate and the applied potential, different CEHDA modes may occur (ie, dripping, cone jetting or multiple jetting). The cone spray pattern is the best CEHDA condition for producing uniform particles. Drug-loaded particles enable precise drug release with minimal batch-to-batch variation. The method can directly introduce the drug into the core layer of the nanoparticle, and the shell polymer can protect the drug in the core layer to a certain extent, and can effectively overcome the initial burst release of the drug. In addition, it has th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/04
CPCB01J13/043
Inventor 陈传品刘文芳邓喆蒋屏曾文昕郭鹏辉
Owner 温州品卓生物科技有限公司
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