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A method of microangiography based on frequency domain oct

A microvascular and frequency-domain technology, applied in the fields of optical detection and biomedical engineering, can solve problems such as high environmental phase stability requirements, unsuitable for clinical applications, high spatial resolution, etc.

Active Publication Date: 2020-10-23
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
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Problems solved by technology

Existing blood flow imaging methods such as color ultrasound Doppler technology, fluorescein angiography, and laser Doppler velocimetry cannot all meet these demanding requirements. They cannot provide high spatial resolution, and often require intravenous injection contrast agent to aid in imaging
Phase-resolved Doppler OCT technology can meet these requirements, but the disadvantage is that it requires high phase stability in the environment and is not suitable for clinical applications.

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  • A method of microangiography based on frequency domain oct
  • A method of microangiography based on frequency domain oct
  • A method of microangiography based on frequency domain oct

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Embodiment Construction

[0015] The present invention will be described in further detail below in combination with specific embodiments and with reference to the accompanying drawings.

[0016] In the present invention, the OCT functional imaging is applied to microangiography to realize the observation and study of the microcirculation in vivo, and to observe the microcirculation in vivo non-invasively. significance.

[0017] A kind of microangiography method based on frequency domain OCT is provided in this specific embodiment, comprises the following steps:

[0018] (1) Build a set of frequency domain OCT system, frequency domain OCT system includes light source, fiber optic coupler, reference arm assembly, sample arm assembly, spectrometer and linear array CCD; Said sample arm assembly includes laser scanning galvanometer in X direction and The laser scanning galvanometer in the Y direction; the light source is an SLED broadband light source; the collimated light of the sample arm assembly hits ...

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Abstract

The invention discloses a microangiography method based on frequency domain OCT. The method comprises the steps that S1, a frequency domain OCT system is constructed; S2, the line on the same positionof two-dimensional spectra in the x scanning direction is obtained, and a two-dimensional spectrum in the y scanning direction is obtained through reconstruction; reconstruction is conducted on linesat each position to obtain a group of the two-dimensional spectra in the y scanning direction; S3, following processing is conducted on all two-dimensional spectra in the y scanning direction to obtain corresponding blood flowing information of the two-dimensional spectra in the y scanning direction; S4, corresponding blood vessel information of the two-dimensional spectra in the y scanning direction is assembled into three-dimensional blood vessel information, and the three-dimensional blood vessel information is converted to a three-dimensional blood vessel image by using three-dimensionalvisible software. By means of the method, more abundant micrangium information can be detected, the requirements on detected environment are lower, and system assembling and adjusting are more simplified.

Description

【Technical field】 [0001] The invention relates to the fields of optical detection and biomedical engineering, in particular to a microangiography method for functional imaging based on a frequency-domain optical correlation tomography (OCT) system. 【Background technique】 [0002] Optical coherence tomography (OCT) is an imaging technique developed rapidly in recent years. While ensuring a certain detection depth, it achieves higher resolution and sensitivity than other methods, so it occupies a place in many imaging methods with its high resolution, high sensitivity, non-invasive and non-contact characteristics, and has a It has a good development prospect and has attracted more and more attention. Optical coherence tomography technology is based on the disciplines of optics, electronics, and computer technology. It combines semiconductor and ultrafast laser technology, ultrasensitive detection, precision automatic control, and computer image processing. After computer X-r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00
CPCA61B5/0066A61B5/489
Inventor 郭晓睿何永红申志远郭翠霞孙占
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV