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Hydroxytyrosol containing nanoemulsion preparation and preparation method of lyophilized agent thereof

A technology of hydroxytyrosol and milk preparations, which is applied in skin care preparations, medical preparations of non-active ingredients, freeze-dried delivery, etc. It can solve the problems of poor stability, color change, and low viscosity of hydroxytyrosol, and achieve Ease of application, enhanced stability, low viscosity effect

Inactive Publication Date: 2018-11-27
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned prior art, the present invention provides a nanoemulsion of hydroxytyrosol, which has good stability, low viscosity, small particle size and is more likely to diffuse and penetrate into the skin, and can be used directly to solve the problem of poor stability of hydroxytyrosol at room temperature, Problems of color change and easy degradation

Method used

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  • Hydroxytyrosol containing nanoemulsion preparation and preparation method of lyophilized agent thereof
  • Hydroxytyrosol containing nanoemulsion preparation and preparation method of lyophilized agent thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Accurately weigh 2.0g of polyethylene glycol 15-hydroxystearate, 1.0g of caprylic capric triglyceride, and 0.72g of hydroxytyrosol, put them in a beaker and place them in a water bath at 70°C as the oil phase; precisely measure 46.28g Purified water was placed in a water bath at 70°C and stirred and blended as the water phase; under the condition of a water bath at 70°C, the oil phase containing hydroxytyrosol was slowly added dropwise to the water phase and fully emulsified until a ribbon with a viscosity similar to that of the aqueous solution was formed. Clear and transparent solution with blue opalescence, obtained o / w type hydroxytyrosol nanoemulsion.

[0045] Add 1.0g (2%) mannitol to each 2ml of the above-prepared nanoemulsion and put it into a vial, put it in a freeze dryer at -40°C, pre-freeze for 4 hours, sublimate and dry for 24 hours, analyze and dry for 6 hours, and freeze-dry to obtain a white and loose shape. Hydroxytyrosol nanoemulsion freeze-dried prepa...

Embodiment 2

[0047] Precisely weigh 2.0g of polyethylene glycol 15-hydroxystearate, 1.0g of caprylic capric triglyceride, and 1.15g of hydroxytyrosol, put them in a beaker and place them in a water bath at 70°C as the oil phase; precisely measure 45.85g Purified water was placed in a water bath at 70°C and stirred and blended as the water phase; under the condition of a water bath at 70°C, the oil phase containing hydroxytyrosol was slowly added dropwise to the water phase and fully emulsified until a ribbon with a viscosity similar to that of the aqueous solution was formed. Clear and transparent solution with blue opalescence, obtained o / w type hydroxytyrosol nanoemulsion.

[0048]Add 1.0g (2%) mannitol to each 2ml of the above-prepared nanoemulsion and put it into a vial, put it in a freeze dryer at -40°C, pre-freeze for 4 hours, sublimate and dry for 24 hours, analyze and dry for 6 hours, and freeze-dry to obtain a white and loose shape. Hydroxytyrosol nanoemulsion freeze-dried prepara...

Embodiment 3

[0050] Accurately weigh 2.0g of 15-hydroxypolyethylene glycol stearate, 1.0g of caprylic capric triglyceride, and 1.5g of hydroxytyrosol, put them in a beaker and place them in a water bath at 70°C as the oil phase; precisely measure 45.5g Purified water was placed in a water bath at 70°C and stirred and blended as the water phase; under the condition of a water bath at 70°C, the oil phase containing hydroxytyrosol was slowly added dropwise to the water phase and fully emulsified until a ribbon with a viscosity similar to that of the aqueous solution was formed. Clear and transparent solution with blue opalescence, obtained o / w type hydroxytyrosol nanoemulsion.

[0051] Add 1.0g (2%) mannitol to each 2ml of the above-prepared nanoemulsion and put it into a vial, put it in a freeze dryer at -40°C, pre-freeze for 4 hours, sublimate and dry for 24 hours, analyze and dry for 6 hours, and freeze-dry to obtain a white and loose shape. Hydroxytyrosol nanoemulsion freeze-dried prepara...

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Abstract

The invention discloses a hydroxytyrosol containing nanoemulsion preparation and a lyophilized agent thereof. The hydroxytyrosol containing nanoemulsion preparation is prepared from hydroxytyrosol, asurface active agent, an oil phase and a water phase. A preparation method of the hydroxytyrosol containing nanoemulsion preparation comprises the steps that 1, the surface active agent and hydroxytyrosol are weighed and added into oil to serve as the oil phase, and the materials are stirred and mixed in a water bath; 2, purified water is weighed and added into a beaker, the materials are placed in the water bath, the oil phase is slowly and dropwise added into the water bath under the water bath condition, and the materials are fully stirred to be completely emulsified until and a clear transparent solution with bluish opalescence and with the viscosity similar to an aqueous solution is formed; 3, the nanoemulsion preparation is frozen and dried, water is removed, and the hydroxytyrosol nanoemulsion freeze-dried preparation is prepared. The hydroxytyrosol nanoemulsion prepared through the method has the advantages of being good in stability, low in viscosity, small in grain size and capable of being diffused and permeating into the skin more easily, the lyophilized preparation is conveneitn to store and transport, and can be added into cosmetics, medicine and healthcare food moreflexibly and conveniently.

Description

technical field [0001] The invention relates to the field of cosmetics and pharmaceutical preparations, in particular to a nanoemulsion freeze-dried preparation containing hydroxytyrosol and a preparation method thereof. Background technique [0002] The chemical name of hydroxytyrosol is 3,4-dihydroxyphenylethanol, and its molecular weight is 154.2. It is a natural antioxidant and widely exists in the branches, leaves and fruits of olive plants, especially in olive trees in the Mediterranean region. High, is the active ingredient of olive oil. In recent years, a large number of studies at home and abroad have confirmed that hydroxytyrosol has strong antioxidant activity. And many other aspects have excellent biopharmacological effects. Therefore, hydroxytyrosol has a wide range of uses due to its special biological and pharmacological activities. In the food industry, it can be used as a natural preservative to prevent food from oxidative deterioration; in the field of n...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/19A61K47/14A61K47/10A61K31/05A61P19/10A61P39/06A61K8/34A61K8/06A61Q19/00A61Q19/02A23L33/10
CPCA23L33/10A23V2002/00A61K8/068A61K8/347A61K9/1075A61K9/19A61K31/05A61K47/10A61K47/14A61P19/10A61P39/06A61Q19/00A61Q19/02A23V2200/30A23V2250/6418
Inventor 王丽丽凌沛学张岱州郭新艳李大伟祝美华孙慧娟张建强陈建英张菊红
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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