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Compound inner membrane of chicken gizzard tablet with sustained release effect, preparation method and application thereof

A technology of compound chicken and gallinaceous gold, which is applied in the field of children's compound chicken gallinaceous tablet preparations, can solve the problems of rapid decrease in blood drug concentration Cmax, rapid disintegration, and influence on the efficacy of drugs, etc.

Inactive Publication Date: 2018-11-27
HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product disintegrates quickly, and the maximum blood concentration Cmax drops rapidly, which in turn affects the efficacy of the drug

Method used

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  • Compound inner membrane of chicken gizzard tablet with sustained release effect, preparation method and application thereof
  • Compound inner membrane of chicken gizzard tablet with sustained release effect, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Xiaoer Compound Ji Nei Jin Sustained-release Tablets are composed of the following raw materials by weight percentage: Liushenqu extract 20%, Ji Nei Jin extract 20%, hydroxypropyl methylcellulose (K15M) 26%, filler 30% , Adhesive 3%, lubricant 1%. The filler is made of microcrystalline cellulose and lactose in a mass ratio of 1:1.

[0039]Weigh 50g of Liushenqu extract, 50g of Gallus gallis extract, 65g of hydroxypropyl methylcellulose (K15M), 37.5g of lactose, and 37.5g of microcrystalline cellulose, pass through a 120 mesh sieve respectively, and mix the extract and auxiliary materials Mix evenly by equal increment method, add 3% P VPK30 (7.5g) 60% ethanol solution to make soft material, granulate through 20 mesh sieve, dry at 60°C, granulate through 20 mesh sieve, add 2.5g hard Magnesium fatty acid is mixed evenly, and the tablet press machine is adjusted, and the tablet is compressed, and the tablet specification is 0.25g / sheet, and the compound chicken inner gold ...

Embodiment 2

[0041] Xiaoer Compound Ji Nei Jin Sustained-release Tablets are composed of the following raw materials by weight percentage: Liushenqu extract 10%, Ji Nei Jin extract 30%, hydroxypropyl methylcellulose (K15M) 35%, filler 20% , Adhesive 4%, lubricant 1%. The filler is made of microcrystalline cellulose and lactose in a mass ratio of 1:1.

[0042] Weigh 25g of Liushenqu extract, 75g of Gallus gallis extract, 87.5g of hydroxypropyl methylcellulose (K15M), 25g of lactose, and 25g of microcrystalline cellulose, pass through a 120-mesh sieve respectively, and separate the extract and auxiliary materials by Mix evenly by the method of equal increase, add 4% PVPK30 (10g) 60% ethanol solution to make soft material, pass through a 20 mesh sieve to granulate, dry at 65°C, pass through a 20 mesh sieve for granulation, and add 2.5g magnesium stearate Mix evenly, adjust the tablet press machine, press the tablet, the tablet specification is 0.25g / tablet, obtains the compound chicken inner...

Embodiment 3

[0044] Xiaoer Compound Ji Nei Jin Sustained-release Tablets are composed of the following raw materials by weight percentage: Liushenqu extract 30%, Ji Nei Jin extract 10%, hydroxypropyl methylcellulose (K15M) 45%, filler 9% , binder 5%, lubricant 1%. The filler is made of microcrystalline cellulose and lactose in a mass ratio of 1:1.

[0045] Take by weighing 75g of Liushenqu extract, 25g of Gallus gallis extract, 112.5g of hydroxypropyl methylcellulose (K15M), 11.25g of lactose, and 11.25g of microcrystalline cellulose, and pass through a 120 mesh sieve respectively, and the extract and The excipients are mixed uniformly according to the method of increasing in equal amounts, and the soft material is made by adding 5% PVPK30 (12.5g) 60% ethanol solution, granulated through a 20-mesh sieve, dried at 60°C, granulated through a 20-mesh sieve, and 2.5g hard Magnesium fatty acid is mixed evenly, and the tablet press machine is adjusted, and the tablet is compressed, and the tabl...

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Abstract

Provided is a compound inner membrane of chicken gizzard tablet with sustained release effect, a preparation method and application thereof. The tablet contains maticated leaven extract, inner membrane of chicken gizzard extract, skeleton material, filler, adhesive, and lubricant, wherein the maticated leaven extract contains more than 2.0% of luteolin. The inner membrane of chicken gizzard extract contains more than 0.5% of proline. The compound inner membrane of chicken gizzard tablet can be used for treating dyspepsia due to spleen and stomach deficiency, food stagnation, emesis, and diarrhea, and is especially suitable for children patients. Drug release lasts longer after oral administration and can maintain a long-term pharmacodynamic concentration, and compared with the corresponding common preparation, the treatment effect is obviously improved, the gastric emptying effect is remarkable, the administration frequency is reduced by at least half, and the patient compliance is obviously improved.

Description

technical field [0001] The invention relates to a compound Ji Nei Jin tablet preparation with sustained release, in particular to a compound Ji Nei Jin tablet preparation for children with sustained release. technical background [0002] The marketed products prepared from Liushenqu and Ji Nei Jin include Pediatric Compound Ji Nei Jin Powder, Pediatric Compound Ji Nei Jin Chewable Tablets, etc. The functions and indications are to invigorate the spleen and appetizer, and eliminate food accumulation. It is used for children with food accumulation, stagnation, vomiting and diarrhea caused by spleen and stomach disharmony. [0003] Ji Nei Jin is a commonly used traditional Chinese medicine. It was first recorded in "Shen Nong's Materia Medica" (poultry) under the item of top-grade Danxiong chicken. Chicken gold contains gastric hormone, keratin, trace pepsin, amylase and a variety of amino acids. Enuresis, spermatorrhea, stone stranguria astringent pain, bile distension hypoc...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K9/22A61P1/14A61P1/08A61P1/12A61K35/57
CPCA61K9/2018A61K9/2054A61K35/57A61K36/00A61K2236/333A61K2236/39A61P1/08A61P1/12A61P1/14A61K2300/00
Inventor 郭中华其木格张立壮刘伟伟张志平张冰冰
Owner HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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