A catalytic up-conversion fluorescent nanomaterial and its preparation method and application

A technology of fluorescent nanomaterials and capabilities, applied in luminescent materials, chemical instruments and methods, materials for wave energy or particle radiation treatment, etc., can solve problems such as difficulty in photodynamic therapy

Active Publication Date: 2021-01-29
QINGDAO UNIV OF SCI & TECH
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  • Claims
  • Application Information

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Problems solved by technology

[0003] However, since the photodynamic therapy of tumor mainly depends on reactive oxygen species (ROS), and the tumor environment is a hypoxic environment, during the treatment process, as the oxygen is gradually consumed and the oxygen concentration decreases, the photodynamic therapy will also decrease. more difficult

Method used

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  • A catalytic up-conversion fluorescent nanomaterial and its preparation method and application
  • A catalytic up-conversion fluorescent nanomaterial and its preparation method and application
  • A catalytic up-conversion fluorescent nanomaterial and its preparation method and application

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[0025] The present invention also provides a preparation method for the up-conversion fluorescent nanomaterial described in the above technical solution, comprising the following steps:

[0026] (1) The chemical composition in the up-conversion fluorescent nanomaterial corresponding to the above-mentioned technical scheme will include Gd(NO 3 ) 3 , Yb(NO 3 ) 3 , Er(NO 3 ) 3 Mix the mixed liquid with soluble manganese salt and urea, and carry out hydrothermal reaction to obtain the precursor of fluorescent material;

[0027] (2) Calcining the precursor obtained in the step (1) to obtain an up-conversion fluorescent nanomaterial with catalytic ability.

[0028] The present invention will include Gd(NO 3 ) 3 , Yb(NO 3 ) 3 , Er(NO 3 ) 3 The mixed liquid with soluble manganese salt is mixed with urea, and undergoes hydrothermal reaction to obtain the precursor of fluorescent material. In the present invention, Gd(NO 3 ) 3 , Yb(NO 3 ) 3 , Er(NO 3 ) 3 and the consum...

Embodiment 1

[0036] (1) Add 37.5535g deionized water into a 50mL beaker, and add 1.4115mL1mol L in turn during stirring -1 Gd(NO 3 ) 3 , 0.585mL 0.1mol L -1 Yb(NO 3 ) 3 , 0.3mL0.05mol L -1 Er(NO 3 ) 3 and 0.15mL 0.1mol L -1 Mn(CH 3 COO) 2 solution, mix well and stir for 5min to obtain 3 ) 3 , Yb(NO 3 ) 3 , Er(NO 3 ) 3 and a mixture of soluble manganese salts;

[0037] (2) Add 3 g of urea to the mixed solution in step (1), and continue to stir for 2 h at room temperature, then transfer to a 50 mL reaction kettle, and perform a hydrothermal reaction at a constant temperature of 85° C. for 3 h;

[0038] (3) After the reaction is completed and the solution is cooled, transfer the sample to a centrifuge tube, -1 The precipitate obtained by centrifuging at a high speed for 5 minutes is the precursor product, which is washed three times with deionized water and ethanol solution respectively, and finally the product is dried in an oven at 60°C for 12 hours; then the nanomaterials ...

Embodiment 2

[0042] Prepare up-conversion fluorescent nanomaterial Gd according to the preparation method of Example 1 2 o 3 :Yb 3+ ,Er 3+ ,Mn 2+ , the difference is that the hydrothermal reaction temperature is 80°C, the sintering temperature is 800°C, the raw material Gd(NO 3 ) 3 , Yb(NO 3 ) 3 , Er(NO 3 ) 3 and Mn(CH 3 COO) 2 The dosage ratio is 0.946:0.039:0.01:0.005 (molar ratio), the Gd obtained in this way 2 o 3 :Yb 3+ ,Er 3+ ,Mn 2+ The molar ratio of Gd, Yb, Er and Mn in the fluorescent nanomaterial is 0.946:0.039:0.01:0.005.

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Abstract

The invention belongs to the technical field of up-conversion fluorescent nanometer materials, and in particular relates to an upconversion fluorescent nanometer material with catalytic ability and its preparation method and application. The up-conversion fluorescent nanomaterial with catalytic ability provided by the present invention comprises a chemical composition of Gd 2 o 3 :Yb 3+ ,Er 3+ ,Mn 2+ The component, the molar ratio of Gd, Yb, Er and Mn in this component is (0.951-x):0.039:0.01:x (x=0.003~0.25). The up-conversion fluorescent nanomaterial provided by the present invention has strong up-conversion fluorescence performance, and can effectively catalyze H 2 o 2 Oxygen production.

Description

technical field [0001] The invention relates to the technical field of up-conversion fluorescent nanomaterials, in particular to an up-conversion fluorescent nanomaterial with catalytic ability and its preparation method and application. Background technique [0002] Up-conversion fluorescent nanomaterials have attracted extensive attention from researchers due to their excellent properties such as high fluorescence efficiency, good stability, and high resolution, and have been widely used in different fields such as anti-counterfeiting identification, solar cells, bioluminescent labels, and up-conversion lasers. prospect. Especially in biomedical tumor treatment, such as photodynamic therapy of tumors, up-conversion fluorescent nanomaterials are used as carriers of photoconverters and photosensitizer drugs to solve a series of problems such as insufficient depth of tumor treatment and low selectivity of ideal photosensitizers. , so that the effect of tumor photodynamic the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/78B01J23/34C01B13/02A61K41/00A61P35/00
CPCA61K41/0057A61P35/00B01J23/002B01J23/34B01J2523/00C01B13/0214C09K11/7769B01J2523/375B01J2523/3775B01J2523/3787B01J2523/72
Inventor 王玮王伟华宋韶欣侯兴龙
Owner QINGDAO UNIV OF SCI & TECH
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