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Method for detecting five sweetening agents in electronic cigarette liquor through ultra-high performance liquid chromatography-tandem mass spectrum

An ultra-high performance liquid phase, tandem mass spectrometry technology, applied in the field of physical and chemical inspection of food additive residues, to achieve the effect of simple pretreatment method, good repeatability, and strong resistance to matrix interference

Active Publication Date: 2018-12-07
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no method for the determination of sweeteners in electronic cigarette liquid. The present invention establishes a simple , Efficient and accurate, it can realize the UPLC-MS / MS method for simultaneous determination of 5 kinds of sweeteners in e-cigarette liquid samples, which better meets the needs of detection and analysis work

Method used

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  • Method for detecting five sweetening agents in electronic cigarette liquor through ultra-high performance liquid chromatography-tandem mass spectrum
  • Method for detecting five sweetening agents in electronic cigarette liquor through ultra-high performance liquid chromatography-tandem mass spectrum

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0033] 1. Instruments and reagents:

[0034] The 5 sweeteners and methanol are all chromatographic grade reagents; they meet the requirements of first-grade water in GB / T 6682.

[0035] Waters TQD quadrupole tandem mass spectrometer; Swiss Mettler AE 163 electronic balance (sensitivity: 0.0001g).

[0036] 2. Sample handling:

[0037] Weigh 100 μL of sample into a 2.0 mL centrifuge tube; add 900 μL of ultrapure water and 25 mg of C18 powder, vortex for 5 minutes, and centrifuge at 8000 r / h for 5 minutes, then filter, and the filtrate is used as the sample solution to be tested in UPLC -MS / MS analysis;

[0038] 3. Prepare and mix the mixed standard working solution; see the summary of the invention for the preparation method, and will not repeat it here.

[0039] 4. UPLC-MS / MS determination 。

[0040]5. Calculation of measurement results: Quantitative analysis is carried out by external standard method, that is, the quantitative ion pair peak area of ​​various sweetener s...

example 2

[0043] According to the method described in Example 1, another e-cigarette liquid sample was selected, and the content of acesulfame potassium in the sample was 1.80 mg / kg.

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Abstract

The invention belongs to the technical field of physical and chemical inspection for food additive residues in electronic cigarette liquor and specifically relates to a method for detecting five sweetening agents in electronic cigarette liquor through ultra-high performance liquid chromatography-tandem mass spectrum. The method is characterized by comprising the following steps: first, weighting the electronic cigarette liquor, and then adding ultrapure water for diluting, and at last, determining the sweetening agents in the electronic cigarette liquor through ultra-high performance liquid chromatography-tandem mass spectrum. According to the method, the sweetening agent residues in electronic cigarette liquor can be quickly and accurately detected. The invention has the advantages of environment-friendly method, accurate result, little interference, high sensitivity and good repeatability.

Description

technical field [0001] The invention belongs to the technical field of physical and chemical inspection of food additive residues in e-cigarette liquid, and mainly relates to a method for measuring five kinds of sweeteners in e-cigarette liquid, specifically a method for direct determination by ultra-high performance liquid chromatography-tandem mass spectrometry after dilution . Background technique [0002] Electronic cigarettes are a new type of tobacco products that have emerged in recent years, also known as electric atomized cigarettes. Electronic cigarettes are mainly composed of battery rods (including light-emitting diodes, batteries, pneumatic switches, control circuits, atomizers and other components) and cartridges. (Including liquid storage cavity and suction nozzle) Composition. Among them, the e-liquid in the pod is the core, and the main components are propylene glycol, glycerin or polyethylene glycol containing nicotine. At the same time, in order to meet ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/06
CPCG01N30/06G01N30/88G01N2030/047G01N2030/062G01N2030/8809
Inventor 杨飞唐纲岭李中皓邓惠敏刘珊珊王颖范子彦边照阳
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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