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Application of polyethylene glycol as active component in preparing psoriasis treating drug and drug thereof

A treatment drug, polyethylene glycol technology, applied in the field of medicine, can solve problems such as high cost

Active Publication Date: 2018-12-11
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcipotriol-betamethasone ointment, a compound preparation of glucocorticoids and vitamin DR derivatives that has been on the market recently, has a slightly better effect than calcipotriol, but its cost is high, so it is of great significance to develop new drugs for the treatment of psoriasis

Method used

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  • Application of polyethylene glycol as active component in preparing psoriasis treating drug and drug thereof
  • Application of polyethylene glycol as active component in preparing psoriasis treating drug and drug thereof
  • Application of polyethylene glycol as active component in preparing psoriasis treating drug and drug thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Weigh 10g polyethylene glycol 400, because polyethylene glycol 400 has a small molecular weight and is in a liquid state, it can be directly used as a psoriasis treatment drug.

Embodiment 2

[0043] Weigh 8g polyethylene glycol 400 and 2g polyethylene glycol 4000 respectively, stir for 10 min under a constant temperature water bath at 60°C, then cool to 40°C, mix and stir uniformly, to obtain a liquid psoriasis treatment drug.

Embodiment 3

[0045] Weigh 7g polyethylene glycol 400 and 3g polyethylene glycol 4000 respectively, stir at 60°C in a constant temperature water bath for 10 minutes, and then cool to 40°C and mix and stir uniformly to obtain a liquid psoriasis treatment drug.

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PUM

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Abstract

The invention relates to an application of polyethylene glycol as an active component in preparing psoriasis treating a drug and the drug thereof. The inventor finds that polyethylene glycol has an obvious treatment effect to psoriasis and can alleviate splenauxea and increase of MDSCs cell populations effectively through tests. The treatment effect of polyethylene glycol is superior to that of afirst-tier drug calcipotriol for clinically treating psoriasis externally according to skin damage area of psoriasis and score of Psoriasis Area and Severity Index (PASI), and polyethylene glycol is free of toxic and side effects, does not lead to skin allergy, is stable and hard to deteriorate, and meanwhile, fixes water molecules through a lot of hydrogen bonds, so that water is kept in keratoderma or corium layer to increase the inventory of skin moisture, enhance the ventilating property of skin to play a moisturizing role, ensure curative effect continuously, and is free of influence to pH value. The pharmaceutical cost is far lower than clinical drugs such as calcipotriol, the economical burden of a patient can be reduced obviously, and the polyethylene glycol has an extremely wide market prospect.

Description

Technical field [0001] The invention relates to the field of medicine, in particular to the application of polyethylene glycol as an active ingredient in the preparation of a psoriasis treatment medicine and its medicine. Background technique [0002] Psoriasis is a common chronic, recurrent, and inflammatory skin disease. Clinically, it mainly manifests as erythema and scaly. Its histopathology is specific. It is manifested by hyperproliferation of epidermal keratinocytes, hyperkeratosis and incomplete keratosis. The spinous layer is thick, and sparse inflammatory cell infiltration around the superficial dermis. The incidence of psoriasis in the natural population is 0.1% to 3%, and its pathogenesis is complicated and easy to recur. Most psoriasis are mild to medium-sized patients, and topical drug therapy is the main treatment method and occupies an indispensable position. [0003] Commonly used external drugs for psoriasis include glucocorticoids, tretinoin, vitamin DR derivat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61P17/06
CPCA61K31/765
Inventor 陈翔匡叶红周星辰朱武鲁艳覃群师
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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