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A self-assembled porphyrin nanomaterial with dual functions of photothermochemotherapy and its preparation method and application

A nanomaterial and self-assembly technology, applied in the fields of materials science and bio-nanomedicine, to achieve excellent photothermochemotherapy performance and excellent fluorescence imaging effect.

Active Publication Date: 2021-01-15
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few studies on the materials that can be used for chemotherapy-photothermal synergistic therapy. How to prepare a nanomaterial with excellent photothermal chemotherapy performance and significant chemotherapeutic effect has important medical value.

Method used

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  • A self-assembled porphyrin nanomaterial with dual functions of photothermochemotherapy and its preparation method and application
  • A self-assembled porphyrin nanomaterial with dual functions of photothermochemotherapy and its preparation method and application
  • A self-assembled porphyrin nanomaterial with dual functions of photothermochemotherapy and its preparation method and application

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preparation example Construction

[0029] The invention provides a method for preparing a self-assembled porphyrin nanomaterial with dual functions of photothermal chemotherapy, comprising the following steps:

[0030] (1) tetrapyridyl porphyrin and chloroform are mixed to obtain aureoporphyrin chloroform solution;

[0031] (2) Milking the aureoporphyrin chloroform solution under the action of an emulsifier, removing the chloroform, and immediately cooling the remaining solution to obtain a self-assembled porphyrin nanomaterial solution.

[0032] The invention mixes tetrapyridyl porphyrin and chloroform to obtain gold porphyrin chloroform solution.

[0033] In the present invention, the preparation method of the tetrapyridyl porphyrin is preferably prepared using the patent reference publication number CN108101918A.

[0034] In the present invention, the mass ratio of the tetrapyridyl porphyrin to the volume of chloroform is preferably 8-15 mg: 1 ml, more preferably 10-12 mg: 1 ml. The mixing method preferabl...

Embodiment 1

[0049] Tetrapyridine porphyrin (10 mg) was dissolved in 1 mL of chloroform organic solvent, and stirred at 600 rpm for 30 min to obtain a tetrapyridine porphyrin chloroform solution. The synthesis of tetrapyridyl porphyrin refers to the preparation method in the patent of CN 108101918A.

[0050]Add tetrapyridyl porphyrin chloroform solution to 0.01M sodium dodecylsulfonate aqueous solution, perform 100W ultrasonic treatment for 0.5min to make milk, after ultrasonic treatment, place the mixed solution in a water bath at 63°C and heat for 30min to evaporate chloroform , and the volatilized solution was put into an ice-water bath under the condition of 0° C. for rapid cooling to obtain a gold porphyrin nanomaterial solution.

Embodiment 2

[0052] Tetrapyridyl porphyrin (8 mg) was dissolved in 1 mL of chloroform organic solvent, and stirred at 4000 rpm for 30 min to obtain a tetrapyridyl porphyrin chloroform solution. The synthesis of tetrapyridyl porphyrin refers to the preparation method in the patent of CN 108101918A.

[0053] Add tetrapyridine base porphyrin chloroform solution to 0.008M sodium dodecylsulfonate aqueous solution, perform 60W ultrasonic treatment for 5 minutes to make milk, and after ultrasonic treatment, place the mixed solution in a water bath at 63°C for 30 minutes to evaporate chloroform. The volatilized solution was put into an ice-water bath at 0° C. for rapid cooling to obtain a gold porphyrin nanomaterial solution.

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Abstract

The invention provides a self assembly porphyrin nanometer material with photo-thermal and chemotherapy dual functions as well as a preparation method and application thereof, and belongs to the technical field of material science and biological nanometer medicine. Tetra pyridyl gold porphyrin and chloroform are mixed to obtain a gold porphyrin chloroform solution; the gold porphyrin chloroform solution is subjected to emulsification under the effects of emulsification agents to remove chloroform; the rest solution is immediately cooled to obtain the self assembly porphyrin nanometer materialsolution. The prepared self assembly porphyrin nanometer material has the advantages that the gold porphyrin with the chemotherapy effect is metallized; the nanocrystallization is realized by a self assembly method; the obtained self assembly porphyrin nanometer material has the chemotherapy effects, and also realizes the light-heat properties. Experiments prove that the prepared self assembly porphyrin nanometer material has excellent photo-thermal and chemotherapy performance, and can be applied to the preparation of medicine for photo-thermal and chemotherapy combined treatment of cancer.

Description

technical field [0001] The invention belongs to the technical field of material science and bionano medicine, and specifically relates to a self-assembled porphyrin nanomaterial with dual functions of photothermal chemotherapy and its preparation method and application. Background technique [0002] With the deterioration of the environment, cancer has become one of the diseases with high morbidity and high mortality in recent years. In the face of cancer, the current common treatment methods are the following: surgical resection, radiotherapy, chemotherapy or phototherapy. According to the severity of the disease, different treatment methods are used to control the disease. [0003] In order to improve the therapeutic effect, there are currently many combinations of synergistic therapies, such as chemotherapy-radiotherapy synergistic therapy, chemotherapy-gene therapy synergistic therapy, etc. Among many synergistic treatment techniques, chemotherapy-photothermal synergis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K41/0076A61P35/00
Inventor 白锋王孝王杰菲钟永王静菡
Owner HENAN UNIVERSITY
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