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Magnetic material with nitric oxide/photothermal synergistic antibacterial effect and its preparation method and application

A technology of photothermal synergy and antibacterial effect, applied in the field of biomedical engineering materials

Active Publication Date: 2020-09-04
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, based on the principle of photothermal sterilization, by treating ferric oxide (Fe 3 o 4 ) surface is modified with polydopamine with obvious photothermal effect, and then a large number of amino groups on the surface of polydopamine are used as the starting point, and methyl acrylate and ethylenediamine are alternately reacted to prepare a poly Dopamine, the outermost layer is polyamide-amine, the nano-core-shell structure and its application of rapid release of nitric oxide under near-infrared conditions have not been reported yet

Method used

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  • Magnetic material with nitric oxide/photothermal synergistic antibacterial effect and its preparation method and application
  • Magnetic material with nitric oxide/photothermal synergistic antibacterial effect and its preparation method and application
  • Magnetic material with nitric oxide/photothermal synergistic antibacterial effect and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1 Fe 3 o 4 Synthesis of @PDA

[0083] (1) anhydrous FeCl 3 Dissolve in ethylene glycol, then add anhydrous sodium acetate and sodium citrate in turn, stir vigorously for 10 minutes, place in a muffle furnace, react for 10 hours at 150°C, and wash with ethanol for 3 times to obtain Fe 3 o 4 Nanoparticles; Wherein, the anhydrous FeCl 3 , the mol ratio of anhydrous sodium acetate and sodium citrate is 1: 0.1: 1; The use amount of described ethylene glycol is to add 50mg anhydrous FeCl in every 5ml 3 count;

[0084] (2) Take the Fe synthesized above 3 o 4 Dissolve in pure water to get Fe 3 o 4 solution, then add 5ml of tris-Hcl solution of dopamine hydrochloride, after ultrasonic (150w / 5min) stabilization, stir at 5°C for 4h, centrifuge and wash with ethanol twice, and vacuum dry at 35°C to obtain Fe 3 o 4 @PDA. Among them, the Fe 3 o 4 The concentration of the solution is 1mg / ml, with 1mg Fe 3 o 4 Dissolved in 1ml pure water; the concentration of sa...

Embodiment 2

[0085] Example 2 Fe 3 o 4 Synthesis of @PDA

[0086] (1) anhydrous FeCl 3 Dissolve in ethylene glycol, then add anhydrous sodium acetate and sodium citrate in turn, stir vigorously for 60 minutes, place in a muffle furnace, react for 24 hours at 400°C, and wash with ethanol for 5 times to obtain Fe 3 o 4 Nanoparticles; Wherein, the anhydrous FeCl 3 , the mol ratio of anhydrous sodium acetate and sodium citrate is 1: 0.5: 5; The use amount of described ethylene glycol is to add 150mg anhydrous FeCl 3 count;

[0087] (2) Take the Fe synthesized above 3 o 4 Dissolve in pure water to get Fe 3 o 4 solution, and then add 10ml of dopamine hydrochloride tris-Hcl solution, after ultrasonic (300w / 30min) stabilization, stir at 35°C for 8h. Centrifuged and washed with ethanol for 3 times, dried under vacuum at 50°C to obtain Fe 3 o 4 @PDA. Among them, the Fe 3 o 4 The concentration of the solution is 5mg / ml; the usage amount of the pure water is to add 5mg Fe in every 1ml ...

Embodiment 3

[0088] Example 3 Fe 3 o 4 Synthesis of @PDA

[0089] (1) anhydrous FeCl 3 Dissolve in ethylene glycol, then add anhydrous sodium acetate and sodium citrate in sequence, stir vigorously for 30 minutes, place in a muffle furnace, react for 12 hours at 200°C, and wash with ethanol for 4 times to obtain Fe 3 o 4 Nanoparticles; Wherein, the anhydrous FeCl 3 , the mol ratio of anhydrous sodium acetate and sodium citrate is 1: 0.25: 2.5; The use amount of described ethylene glycol is to add 80mg anhydrous FeCl in every 5ml 3 count;

[0090] (2) Take the Fe synthesized above 3 o 4 dissolved in pure water, to obtain Fe 3 o 4 solution, then add 8ml of tris-Hcl solution of dopamine hydrochloride, after ultrasonic (200w / 15min) stabilization, stir at 25°C for 6h, centrifuge ethanol wash twice, vacuum dry at 25°C to obtain Fe 3 o 4 @PDA. Among them, the Fe 3 o 4 The concentration of the solution is 2.5mg / ml; the usage amount of the pure water is to add 2.5mg Fe in every 1ml 3...

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Abstract

The invention discloses a magnetic material with a nitric oxide / photo-thermal synergic antibacterial function as well as a preparation method and an application of the magnetic material. The preparation method comprises the following steps: firstly, synthesizing Fe3O4 granules which are uniform in particle size and remarkable in magnetic effect by using a hydrothermal method; modifying the surfaceof Fe3O4 by a layer of poly-dopamine PDA with a remarkable photo-thermal effect; and finally by taking a great amount of amino groups on the surface of the poly-dopamine as initial points, enabling methyl acrylate and ethidene diamine to react alternatively to prepare a structure with ferroferric oxide as a core, poly-dopamine as a middle part and twig-shaped polyamide-amino Fe3O4@PDA@PAMAM as anoutermost layer, and further loading nitric oxide, thereby obtaining the magnetic material with the nitric oxide / photo-thermal synergic antibacterial function. By adopting the magnetic material, sterilization can be achieved by heat generated through near-infrared radiation, and rapid NO (Nitric Oxide) release is promoted, photo-thermal synergic sterilization is achieved, and furthermore bacteriaare rapidly separated through magnetic iron oxide, so that the sterilization and purification effect is further improved.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, and in particular relates to a magnetic material with synergistic antibacterial effect of nitric oxide / light and heat, and a preparation method and application thereof. Background technique [0002] Multidrug-resistant (MDR) bacterial infections, especially MDR Gram-negative and positive bacterial infections, have become one of the greatest threats to global public health. "Superbugs" are spreading around the world at an alarming rate and are resistant to most or all currently available antibiotics. Unfortunately, the development of new antibiotics has not been accompanied by an increase in resistant bacteria, and the growing prevalence of infections with multidrug-resistant and pan-drug-resistant pathogens, coupled with a lack of new safe and effective antimicrobials, has become a public Health, environment and food safety are extremely serious issues. Therefore, there is an urg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/00A61P31/04A61P31/10A61L31/16
CPCA61K33/00A61K41/0052A61L31/16A61K2300/00
Inventor 俞思明李国巍马栋薛巍
Owner JINAN UNIVERSITY
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