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Chromium containing compositions for improving health and fitness

A technology of chromium complex and chromium histidine, which can be used in the direction of active ingredients of heavy metal compounds, medical preparations containing active ingredients, drug delivery, etc., and can solve problems such as unsafe and unhealthy

Pending Publication Date: 2018-12-21
뉴트리션21엘엘씨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, methods such as anabolic steroids are not healthy or safe for most people

Method used

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  • Chromium containing compositions for improving health and fitness
  • Chromium containing compositions for improving health and fitness
  • Chromium containing compositions for improving health and fitness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] Insulin has a stimulatory effect on muscle protein synthesis in the presence of sufficient whole protein and / or essential amino acids (EAAs), whereas it has an inhibitory effect on protein breakdown under conditions of low blood EAA concentrations. We determined the effect of CrPic / CrHis+amylopectin (CAP) on changes in EAA, insulin plasma concentrations, and fractional rate of muscle protein synthesis (FSR). Using a double-blind, crossover design, 10 subjects (6 males, 4 females) consumed 6g whey protein + 2g CrPic / CrHis + pullulan (WCAP) or 6g whey protein (WP) after an overnight fast. FSR was measured using primed, continuous infusion of cyclic-d5-phenylalanine and serial muscle biopsies at 2, 4 and 8 hours. Plasma EAA and insulin were measured by ion-exchange chromatography and ELISA, respectively. Following the 4 hour biopsy, subjects ingested their respective supplements, completed 8 sets of bilateral isotonic leg stretches @ 80% of their estimated 1-RM, and obtai...

Embodiment 2

[0188] Example 2 was performed using the general procedure described herein. DOMS: A comparative model with 2 independent variables (control and WCAP) and 6 dependent variables (maximal isometric and isokinetic voluntary strength, range of motion, upper arm circumference, plasma creatine kinase activity, and muscle soreness) was used. Two-way repeated measures analyzes of variance and paired t-tests were used to examine differences in changes in the dependent variable over time between control and WCAP conditions (before, after, and after 30 min of exercise, and after 1, 2, 3, 4, 7 , 10 and 14 days).

[0189] Twenty healthy subjects (10 males and 10 females) with no history of upper arm injury and no experience in endurance training. In a single-blind study, subjects were divided into control group and WCAP group, and each subject performed 10 sets of 6 maximal isokinetic (90° s-1) eccentric movements of the elbow flexor muscles on a ergometer, each arm at On a ergometer, 2 ...

Embodiment 3

[0192] Aerobic recovery: Nine male, endurance-trained cyclists performed interval training followed by 4-h recovery and subsequent endurance testing to failure at 70% VO2 max on three different days.

[0193] Immediately following the 2-h recovery after the first exercise bout, subjects drank equal volumes of WCAP, protein and fluid replacement (FR) or carbohydrate replacement (CR) in a single-blind randomized design. The carbohydrate content is equivalent to WCAP and CR, and the protein content is equivalent to WCAP and FR. Time to exhaustion (TTE), mean heart rate (HR), perceived exertion score (RPE) and total work of endurance exercise (WT) were compared between trials. TTE and WT were significantly increased in the WCAP group compared with the FR and CR groups. This suggests that WCAP is an effective recovery aid between exhausting bouts of aerobic exercise and that WCAP can improve exercise endurance.

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Abstract

Administration of certain chromium complexes in combination with a starch provide unexpected benefits regarding increasing amino acid absorption, protein synthesis, exercise tolerance, lean muscle mass, skeletal muscle hypertrophy, muscle power, muscle endurance, muscle strength, FSR, and decreasing delayed onset muscle soreness, muscle protein breakdown, and fat mass.

Description

[0001] Incorporated by reference into related applications [0002] Any and all priority claims identified in the Application Data Sheet, or any corrections thereof, are hereby incorporated by reference pursuant to 37 CFR 1.57. This application claims the benefit of U.S. Provisional Application No. 62 / 285,014, filed February 11, 2016. The aforementioned applications are hereby incorporated by reference in their entirety and are hereby expressly made a part of this specification. technical field [0003] The present disclosure relates to compositions for use in persons involved in athletic training (elite and amateur athletes as well as exercise inexperienced individuals). Background technique [0004] Embodiments relate to compositions comprising, consisting essentially of, or consisting of a chromium complex and a starch, for improving muscle health. In some aspects, the composition includes chromium picolinate complex, chromium histidine complex, and pullulan. In some a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K31/28A23L33/165A61K31/718A23L33/17A23L33/125
CPCA61K31/718A23L33/165A23L33/17A23L33/125A61K31/198A61K31/555A61K31/732A61K38/018A61K33/24A61K2300/00A61K31/28A23L33/16A23V2002/00A61K9/08A61K9/14A61K36/899A61K45/06
Inventor J·R·科莫罗夫斯基
Owner 뉴트리션21엘엘씨
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